Custom Peptides
Cayman Chemical on-AE3-208 10mg
An antagonist of the EP4 receptor (Ki = 1.3 nM) which less potently affects EP3, FP, and TP receptors (Kis = 30, 790, and 2,400 nM, respectively) and is without effect on other prostanoid receptors; implicates EP4 signaling in immune and autoimmune responses, inflammation, and cancer
New England Biolabs, Inc. Trypsin-digested BSA MS Standard (CAM-modified) – 500 pmol
This standard is a complex mixture of peptides produced by the tryptic digest of reduced and alkylated Bovine Serum Albumin (BSA). This peptide mixture can be used to test a Matrix-Assisted Laser Desorption/Ionization Time-Of-Flight (MALDI-TOF) or Electrospray Ionization (ESI) mass spectrometer (TOF, Q-TOF or Ion Trap).
Cayman Chemical PntoIc AcId 10mg
An intermediate in the biosynthesis of D-pantothenic acid and, subsequently, CoA
Cayman Chemical FadracIclIb 10mg
An inhibitor of Cdk2 and Cdk9 (IC50s = 4.5 and 20.5 nM, respectively); selective for Cdk2 and Cdk9 over Cdk1, -4, and -7 (IC50s = 278, 193, and 232 nM, respectively); inhibits the proliferation of COLO 205 cells (IC50 = 0.31 µM); inhibits proliferation in a panel of five breast cancer cell lines (IC50s = <0.4 µM for all); decreases phosphorylation of the RNA polymerase II C-terminal domain and RB and induces apoptosis in COLO 205 cells; reduces tumor volume in an EoL-1 mouse xenograft model at 40 and 55 mg/kg; inhibits tumor growth in an HL-60 mouse xenograft model at 70 mg/kg
Bachem (D-Ala2)-Gastric Inhibitory Polypeptide (human) Trifluoroacetate
(D-Ala2)-Gastric Inhibitory Polypeptide (human) Trifluoroacetate, H-Tyr-D-Ala-Glu-Gly-Thr-Phe-Ile-Ser-Asp-Tyr-Ser-Ile-Ala-Met-Asp-Lys-Ile-His-Gln-Gln-Asp-Phe-Val-Asn-Trp-Leu-Leu-Ala-Gln-Lys-Gly-Lys-Lys-Asn-Asp-Trp-Lys-His-Asn-Ile-Thr-Gln-OH, 444073-04-5, C226H338N60O66S, Mr 4983.53, 0.5mg. (D-Ala2)-GIP (human), [DAla2] Gastric Inhibitory Peptide (GIP), human. GIP receptor agonist.
Cayman Chemical BazedoxIfenacetate 10mg
An indole-based SERM that binds to both ERα (IC50 = 26 nM) and ERβ (IC50 = 99 nM); antagonizes 17β-estradiol-dependent and hormone-independent growth of breast cancer cell proliferation (80% reduction with 10 nM) in a manner related to cell cycle arrest and downregulation of cyclin D1 and ERα
Cayman Chemical VInorelbIntartrate 10mg
An inhibitor of microtubule polymerization that blocks mitosis at the metaphase/anaphase transition, preventing HeLa cell proliferation (IC50 = 1.25 nM)
Cayman Chemical ColchIcosIde 10mg
A glycoside form of 3-demethylcolchicine; does not displace [3H]-colchicine from rat brain tubulin in vitro at 25 μM; increases CYP2C9 and CYP2E1 levels in primary human hepatocytes at 1 and 10 μM
Cayman Chemical PImelIc DIphenylamIde 106 10mg
A slow, tight-binding inhibitor of class I HDACs, progressively binding HDACs and remaining bound after wash-out; inhibits class I HDACs (IC50 = 150, 760, 370, and 5,000 nM for HDAC1, 2, 3, and 8, respectively) but not class II HDACs (IC50 > 180 µM for HDAC4, 5, and 7)
Cayman Chemical RucaparIbphosphate 10mg
A PARP1 inhibitor; reduces PARP1 activity in D283 Med cancer cells by 91.7% at 1 µM; selectively inhibits the proliferation of MDA-MB-436 cancer cells expressing mutant BRCA1 (IC50s = 1.3 µM) over MCF-7 cancer cells expressing wild-type BRCA1 and BRCA2 (IC50s = 20.2 µM); potentiates temozolomide-induced growth inhibition in D283 Med and D384 Med cells at 0.4 µM; potentiates temozolomide-induced delays in tumor growth in D283 Med and D384 Med mouse xenograft models at 1 mg/kg per day
Cayman Chemical 7methoxy ApIgenInIdInCLOr 10mg
A 3-deoxyanthocyanin; active against radial growth of G. sorghi and spore germination of P. oryzae (IC50 = 50 ppm for both)
Cayman Chemical alcIs4 7 10 13 16Docosape 10mg
A more lipid-soluble form of all-cis-4,7,10,13,16-DPA
Cayman Chemical StIrIpentol 10mg
An antiepileptic compound; positive allosteric modulator of GABAA receptors that potentiates GABA-mediated activation of α3 subunit-containing GABAA receptors; inhibits GABA reuptake in vitro and increases the release of GABA in neonatal rat hippocampal slices; inhibits LDH1 and LDH4 at 500 µM
Cayman Chemical DexmedetomIdIn 10mg
An α2-AR agonist; selectively binds to α2-ARs over α1-ARs (Kis = 0.015 and 5 nM, respectively); prevents increases in CTnI, as well as reduces myocardial apoptosis, pyroptosis, and ferroptosis in a mouse model of CLP-induced sepsis at 50 UG/kg; induces sedation and decreases mechanical nociception in cats at 40 UG/kg