Drug Discovery Research Screening Libraries
Cayman Chemical Kratom AlkaloId MIxture 1ea
A mixture containing alkaloids found in M. speciosa (Kratom) in an ammonia in methanol solution; designed for use in methods development and as a reference standard for these substances during routine analytical checks using HPLC or LC-MS instrumentation; intended for research and forensic applications
AdipoGen Rebaudioside A
Chemical. CAS 58543-16-1. Formula C44H70O23. MW 967.01. Rebaudioside A is a glucosylated steviol glycoside studied and used as a non-glycemic sweetener. It is one of the predominant steviol glycosides isolated from S. rebaudiana leaves. Rebaudioside A is a alpha-glucosidase inhibitor with IC50=35µg/ml and can inhibit ATP-sensitive K-channels. In vitro rebaudioside A stimulated the insulin secretion from MIN6 cells in a dose- and glucose-dependent manner. It increases glucagon-like peptide 1 GLP-1 secretion in a 2-dimensional mouse intestine model. Rebaudioside A is metabolized by gut microbiota to steviol. Rebaudioside A shows antioxidant activity on reducing cellular reactive oxygen species. It is an activator of Nrf2 and is a potential candidate hepatoprotective agent.
AdipoGen R-3-Hydroxymyristic acid
Chemical. CAS 28715-21-1. Formula C14H28O3. MW 244.4. Synthetic. Hydroxy fatty acid used to study its role in biological processes such as oxidative stress, inflammation and insulin resistance. Used in endotoxin and lipid A research, since it is one of two major components of bacterial Lipid A. Shows antifungal activity. Compound could be used as analytical reference in assaying food samples.
AdipoGen DL-Methionine
Chemical. CAS 59-51-8. Formula C5H11NO2S. MW 149.21. Synthetic. Essential amino acid involved in various biochemical processes in humans and mammals. Important in angiogenesis, the growth of new blood vessels and supplementation may be beneficial in diseases such as Parkinsons, schizophrenia, asthma or allergies, as well as in radiation, copper poisoning, alcoholism or depressions. Through transmethylation it can be converted to S-adenosylmethionine, a primary methyl donor that methylates compounds to form such products as creatine and phosphatidylcholine. Methionine can be converted to cysteine, a precursor of glutathione and taurine. These molecules may regulate intestinal epithelial oxidative status, and may contribute to intestinal mucosal integrity and gut function. Overconsumption of methionine has been associated to cancer growth. Restriction of methionine can increase lifespans and inhibit cancer growth. Used in livestock nutrition.
AdipoGen Dihydrokaempferol
Chemical. CAS 104486-98-8. Formula C15H12O6. MW 288.25. Synthetic. Flavanonol derived from plant source. Precursor of kaempferol. Shown to stimulate glucose uptake and improve insulin resistance by inducing adipogenesis through increased PPAR2 expression. Anti-inflammatory compound.
Enzo Life Sciences SCREEN-WELL Hematopoietic Toxicity library (100µl/well)
The SCREEN-WELL Hematopoietic Toxicity Library is a focused collection of 115 compounds with defined and diverse hematopoietic toxicity, including myelosuppression, neutropenia, leukopenia, anemia, and many more. A variety of structurally and mechanistically different compound classes are included, as well as nontoxic controls. The compounds are dissolved in DMSO at 10mM and aliquoted into deep-well plates. The library is an essential tool for predictive toxicology screening and assay development. Long Term Storage: -80°C. Applications: HTS .
Abcam AS-041164, PI3K gamma inhibitor, 5MG
MW 249.24 g/mol, Purity >98%. Potent PI3K inhibitor with selectivity for PI3Kγ (IC₅₀ = 70 nM), compared to PI3Kα, β and δ (IC₅₀ values are 240 nM, 1.45 and 1.70 μM, respectively). Shows little or n o activity against 38 other common kinases. Blocks neutrophil migration. Active in vivo.
The product is subject to the following: Abcam Restricted Use Statement
Abcam (±)-Octanoylcarnitine chloride, lipid metabolism intermediate, 50MG
MW 323.85 Da. Homolog of acetylcarnitine chloride (ab141121). Acylcarnitines are important intermediates in lipid metabolism.
The product is subject to the following: Abcam Restricted Use Statement
Abcam (±)-Propionylcarnitine chloride, homolog of acetylcarnitine chloride, 50MG
MW 252.73 g/mol, Purity >98%. Naturally occuring homolog of acetylcarnitine chloride (ab141121). Essential for mitochondrial fatty acid transport and high-energy phosphate exchange.
The product is subject to the following: Abcam Restricted Use Statement
AdipoGen Progranulin h untagged
Protein. Signal peptide and human progranulin aa 1-593 is untagged. Reflects the native sequence with no additional aa. Source HEK 293 cells. Endotoxin content <0.01EU/µg purified protein LAL test Lonza. Lyophilized. Contains PBS. Purity >98% SDS-PAGE. Progranulin PGRN is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration FTLD. In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer‘s Disease AD and potentially for MCI Mild Cognitive Impairment. Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.
AdipoGen NMNAT3 hHishighly active
Protein. Human full-length NMNAT3 aa 1-252 is fused at the N-terminus to a His-tag. Source E. coli. Endotoxin content N/A. Liquid. In 50mM TRIS-HCl, pH 8.0, containing 300mM sodium chloride, 1mM DTT and 10% glycerol. Purity >95% SDS-PAGE. Mitochondrial NMNAT isoform. Catalyzes the formation of NAD from nicotinamide mononucleotide NMN and ATP. Can also use the deamidated form of nicotinic acid mononucleotide NAMN as substrate with the same efficiency. Can use tiazofurin monophosphate as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD. For the pyrophosphorolytic activity, mitochondrial NMNAT isoform can use NAD, NADH, NAAD, nicotinic acid adenine dinucleotide phosphate NHD, nicotinamide guanine dinucleotide NGD as substrates. Fails to cleave phosphorylated dinucleotides NADP, NADPH and NAADP. Protects against axonal degeneration following injury.
AdipoGen Lovastatin
Chemical. CAS 75330-75-5. Formula C24H36O5. MW 404.6. Synthetic. Statin compound. Potent competitive HMG-CoA reductase inhibitor. Anti-hypercholesterolemic agent. Cholesterol/isoprenoid biosynthesis inhibitor. Blocks the production of mevalonate, a critical compound in the production of cholesterol and isoprenoids. Inhibits the isoprenylation of Ras and Rho family GTPases. Causes cell cycle arrest in G1 and G2/M phases through modulation of proteasome in cancer cell lines. Smooth muscle cell proliferation inhibitor. Apoptosis inducer. Anticancer compound. Anti-adhesive, immunomodulatory and anti-inflammatory compound. Stimulates bone formation. Increases cellular resistance to anticancer agents such as doxorubicin and etoposide Prod. No. AG-CR1-3572 http//www.adipogen.com/ag-cr1-3572/etoposide.html . Suppresses ICAM-1-LFA-1 interactions, which blocks virus replication and infection. Anti-hypertensive agent. Suppresses TNF-induced NF-kappaB activation.
AdipoGen Pioglitazone
Chemical. CAS 111025-46-8. Formula C19H20N2O3S. MW 356.4. Thiazolidinedione TZD reference compound. Selective PPARgamma agonist. Selectively activates PPARgamma-1. Anti-diabetic , decreasing insulin resistance in adipose tissue. Is about one tenth as potent as rosiglitazone. Lipid metabolism modulator. Estrogen synthesis inhibitor. NF-kappaB inhibitor. Neuroprotective.
AdipoGen MOTS-c K14Q Mutant human
Chemical. Formula C100H148N28O23S2 . C2HF3O2. MW 2174.6 . 114.0. Synthetic. The mitochondria-derived peptide MDP MOTS-c promotes biosynthesis of the endogenous AMP analog AICAR and consequently AMP-activated protein kinase AMPK. It induces cellular and systemic glucose uptake and improves insulin sensitivity and has been shown to prevent diet-induced obesity DIO in mice. This K14Q mutant of MOTS-c has been shown to be associated with exceptional longevity and may be interesting for aging research.