Bioactive Small Molecules
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Filtered Search Results
Medchemexpress LLC Myelin Basic Protein | 50UL
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Myelin Basic Protein | 50UL
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Medchemexpress LLC BMS-433771 dihydrochloride hydrate | 543700-67-0 | 98.0% | 1 ML
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This dihydrochloride hydrate is a respiratory syncytial virus (RSV) fusion inhibitor supplied as a 10 mM solution in DMSO for research use. It is provided with supporting analytical data and handling guidance.
- Orally active RSV fusion inhibitor.
- Supplied as 10 mM solution in DMSO, 1 ML.
- Purity 98.0%.
- Molecular weight 468.38 g/mol.
- Appearance off-white to light yellow solid (supplied as solution).
- Storage in solvent: -80°C up to 6 months, -20°C up to 1 month.
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Apexbio Technology LLC SNS-032 (BMS-387032) 345627-80-7 100mg
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SNS-032 (BMS-387032 CAS 345627-80-7) is a selective inhibitor of cyclin-dependent kinases (CDKs) 2 7 and 9 with reported IC50 values of 38 nM 62 nM and 4 nM respectively By targeting CDKs involved in both cell cycle regulation and transcription SNS-032 disrupts phosphorylation of the C-terminal domain (CTD) of RNA polymerase II at Ser2 and Ser5 indicating effective inhibition of CDK9 and CDK7 In cellular models such as chronic lymphocytic leukemia (CLL) SNS-032 reduces CTD phosphorylation in a time- and concentration-dependent manner This compound is valuable in studying CDK-mediated transcriptional and cell cycle processes in cancer research
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Medchemexpress LLC N-cyclopropyl-2,4-difluoro-5-((2-(pyridin-2-ylamino)thiazol-5-ylmethyl)amino)benzamide | 639858-32-5 | 99.6% | 10MG
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N-cyclopropyl-2,4-difluoro-5-((2-(pyridin-2-ylamino)thiazol-5-ylmethyl)amino)benzamide | 639858-32-5 | 99.6% | 10MG
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Cayman Chemical Tpl2 KInase InhIbItrhydroc 1mg
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A Tpl2 inhibitor (IC50 = 0.05 µM); selective for Tpl2 over MEK, p38 MAPK, Src, MK2, and PKC (IC50s = >40, 180, >400, 110, and >400 µM, respectively); inhibits LPS-induced TNF-α production in isolated human monocytes and whole blood (IC50s = 0.7 and 8.5 µM, respectively); enhances differentiation induced by calcitriol in HL-60 and U937 cells at 5 µM; inhibits the proliferation of KG-1a leukemia cells at 5 µM
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Medchemexpress LLC MMG-11 | 313254-94-3 | 306.27 | 100 MG
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MMG-11 is a potent and selective human TLR2 antagonist with low cytotoxicity. It inhibits both TLR2/1 and TLR2/6 signaling with IC50s of 1.7 μM for Pam3CSK4-induced hTLR2/1 and 5.7 μM for Pam2CSK4-induced hTLR2/6 responses.
- Potent and selective human TLR2 antagonist.
- Low cytotoxicity.
- Inhibits both TLR2/1 and TLR2/6 signaling with IC50s of 1.7 μM for Pam3CSK4-induced hTLR2/1 and 5.7 μM for Pam2CSK4-induced hTLR2/6 responses.
- Does not show cellular toxicity or interference with signaling induced by other TLR agonists, IL-1β or TNF.
- Exhibits no cytotoxic effects up to 100 μM in peripheral blood mononuclear cells (PBMCs).
- Effective inhibition of TLR2/1 and TLR2/6 signaling.
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Cayman Chemical PNU 112455A 5mg
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A Cdk2 and Cdk5 inhibitor (Ki = 2 µM for both); inhibits dexamethasone-induced hyperphosphorylation of tau and cell death in PC12 cells expressing human tau at 1 and 10 µM
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Cayman Chemical ActIvATd SureLIghtRPhycoe 5mg
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SMCC-Activated SureLight™ R-phycoerythrin Uses: Custom antibody labeling, fluorescence-activated cell sorting, flow cytometry, Luminex, and T-cell Labeling
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Cayman Chemical DIprovocIm-1 5mg
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An agonist of TLR1/TLR2; induces TNF-α release in THP-1 cells (EC50 = 110 pM); increases the production of ovalbumin-specific IgG1 in wild-type mice sensitized to ovalbumin at 10 mg/kg; enhances anti-PD-L1 antibody-induced activation of cytotoxic T lymphocytes, reduction of tumor growth, and increases in survival in a B16/F10 murine melanoma model
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000382879 BMS-986176 1MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000382813 BMS-986176 10MM 1ML
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Selleck Chemical LLC DC661 S8808-1G
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DC661 is capable of deacidifying the lysosome and inhibiting autophagy significantly better than HCQ DC661 induces apoptosis
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Selleck Chemical LLC NIK SMI1 S8941-10MM/1ML
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NIK SMI1 is a highly potent and selective NF- B-inducing kinase (NIK) inhibitor with Ki of 0 23 nM for NIK-catalyzed hydrolysis of ATP to ADP
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Selleck Chemical LLC Xanthosine S9369-10MG
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Xanthosine (Xanthine riboside) is an intermediate in purine metabolism formed from IMP and forming GMP
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Selleck Chemical LLC Adavivint S8761-25MG
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Adavivint (SM04690 Lorecivivint) is a potent and specific inhibitor of canonical Wnt signaling with an EC50 of 19 5 nM for inhibiting the TCF/LEF reporter It is 150- to 500-fold more potent than the other known Wnt inhibitors across multiple cellular assays
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