Bioactive Small Molecules
Cayman Chemical ActIphenol 5mg
A bacterial metabolite with antiviral activity; active against coxsackievirus B3 and influenza A (IC50s = 14.37 and 34.4 UG/ml, respectively); potentiates activity of miconazole against C. albicans in a disc assay at 50 UG/disc
AdipoGen Zin3 AM (100 µg)
Chemical. CAS: 562102-46-9. Formula: C46H44F2N2O20. MW: 982.85. Synthetic. Zin3 AM is a cell-permeable Zn2+-selective indicator (Absorption=456nm), that once it enters the cell is hydrolized by esterases to convert the bright fluorescent Zin3 (Ex/Em: ~494/516nm). Zin3 is suitable for detection of Zn2+ concentrations in the 1–100 nM range and it has shown to be very Zn2+-sensitive and Zn2+-specific. The cell permeant AM-ester is useful for detecting low intracellular Zn2+ levels and small concentration changes. Zin3 exhibits high Zn2+-binding affinity that is unperturbed by Ca2+ concentrations up to at least 1 µM (Kd (Zn2+) (in buffer): ~15nM). In addition, Zin3 exhibits a >50-fold increase in fluorescence in response to saturating levels of Zn2+. This dye is usedpredominantly for imaging applications, but has also used in cell-based microplate assays and flow cytometry protocols. The product is typically loaded into cells by adding the dissolved indicator to medium containing cells.
Abcam gamma-DGG (gamma-D-Glutamylglycine), Ionotropic glutamate antagonist, 50MG
MW 204.18 Da, Purity >99%. Ionotropic glutamate receptor antagonist that has been used as a rapidly dissociating, low affinity competitive antagonist at AMPA receptors.
The product is subject to the following: Abcam Restricted Use Statement
Cayman Chemical LGD 6972amonIum salt 5mg
A GCGR antagonist; reduces glucagon-induced hyperglycemia in wild-type mice; reduces blood glucose levels in mouse models of diabetes
Medchemexpress LLC OBI-992 drug-linker | 3039487-10-7 | 96.6% | 2173.46 | 5 MG
OBI-992 drug-linker is a drug-linker conjugate composed of a TOP I inhibitor Exatecan and a linker. It exhibits antitumor property in mouse models and can be used for the synthesis of ADC OBI-992.
- Appears as a solid.
- Color is white to yellow.
- Exhibits antitumor property in mouse models.
- Can be used for the synthesis of ADC OBI-992.
Medchemexpress LLC Fmoc-Dap(Boc)-OH | 162558-25-0 | 100.0% | 426.46 | 10 G
Fmoc-Dap(Boc)-OH is an amino acid derivative featuring an Fmoc protecting group. It is utilized in the synthesis of bicyclic peptide tachykinin NK2 antagonists. This product is intended for research use only and is not sold to patients.
- Amino acid derivative
- Contains an Fmoc protecting group
- Used to synthesize bicyclic peptide tachykinin NK2 antagonists
- For research purposes only
Medchemexpress LLC Harmine (Standard) | 442-51-3 | 212.25 | 25 MG
Harmine (Standard) is the analytical standard of Harmine, intended for research and analytical applications. It is a natural dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with anticancer and anti-inflammatory activities, exhibiting high affinity for the 5-HT2A serotonin receptor with a Ki of 397 nM. The compound is a reference standard supplied assay, commonly used in qualitative, quantitative, and methodological research experiments.
- Analytical standard for research and analytical applications.
- Natural dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor.
- Possesses anticancer and anti-inflammatory activities.
- High affinity for 5-HT2A serotonin receptor (Ki of 397 nM).
- Reference standard supplied assay.
- Commonly used in qualitative, quantitative, and methodological research experiments.
- Suitable for HPLC, GC, and MS applications.
Sigma Aldrich Fine Chemicals Biosciences Fluspirilene | 1841-19-6 | MFCD00055137 | 10 mg
Fluspirilene | Purity: ≥98% | Mol Wt: 475.57 | 1841-19-6 | MFCD00055137 | 10 mg
Cayman Chemical ANTIBODY LYN-1604 10mg
An activator of ULK1 (EC50 = 18.94 nM); increases Beclin 1, LC3-II, and total LC3 protein levels and reduces levels of p62 in human MDA-MB-231 TNBC cells in a concentration-dependent manner, indicating an increase in autophagy; increases the cleavage of the pro-apoptotic protein caspase-3; decreases the viability of MDA-MB-231 cells in vitro (IC50 = 1.66 μM); reduces tumor growth in an MDA-MB-231 mouse xenograft model at 25, 50, and 100 mg/kg
Cayman Chemical A2AR AgonIst-1 5mg
An agonist of the adenosine A2A receptor and an inhibitor of ENT1 (Kis = 4.39 and 3.47 µM, for the human receptor and guinea pig transporter, respectively); decreases adenosine uptake by 80% in PC12 cells at 61 µM and increases brain levels of adenosine in a transgenic mouse model of Huntington’s disease at 20 mg/kg; rescues motor performance and increases survival in a transgenic mouse model of Huntington’s disease at 0.11 mg/kg
Cayman Chemical Prdopdne 5mg
A σ1 receptor ligand and dopaminergic stabilizer; binds to the σ1 receptor and dopamine D2 receptor in the high-affinity state (Kis = 81.3 and 7,521 nM, respectively); increases striatal DOPAC levels and locomotor activity, as well as inhibits amphetamine-induced locomotor activity, in rats at 100 µmol/kg; improves motor function and reduces striatal mHtt aggregates in the R6/2 mouse model of Huntington’s disease at 5 or 6 mg/kg; prevents muscle atrophy and the loss of innervated neuromuscular junctions in the SOD1-G93A mouse model of ALS at 30 mg/kg
eMolecules 1013-69-0 | Medchem Express | Noreugenin | 5mg | 495800935 | HY-N3029 | MFCD03001435 | 192.17 | C10H8O4
Ambeed | (2R3R3aS9aR)-2-(Hydroxymethyl)-6-imino-33a69a-tetrahydro-2H-furo[2345]oxazolo[32-a]pyrimidin-3-ol hydrochloride | 1g | 490494716 | A112401 | 10212-25-6 | MFCD00012636 | 261.660 | C9H12ClN3O4
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Medchemexpress LLC OT-R antagonist 1 | 364071-17-0 | C28H29N3O4 | 1 MG
OT-R antagonist 1 is a new, potent, and selective nonpeptide low molecular weight oxytocin receptor (OT-R) antagonist. It effectively inhibits oxytocin-evoked intracellular Ca2+ mobilization and demonstrates high selectivity against vasopressin receptor subtypes. It has shown in vivo activity by blocking oxytocin-induced contraction of isolated rat uterine strips and inhibiting spontaneous uterine contractions in pregnant rats.
- Potent and selective nonpeptide oxytocin receptor (OT-R) antagonist
- Effectively inhibits oxytocin-evoked intracellular Ca2+ mobilization
- Demonstrates high selectivity against vasopressin receptor subtypes
- Competitively inhibits binding of [3H]oxytocin and peptide antagonists to human and rat oxytocin receptors
- Blocks oxytocin-induced contraction of isolated rat uterine strips in vivo
- Inhibits spontaneous uterine contractions in pregnant rats near term
Medchemexpress LLC HY-N0462 5mg Medchemexpress, Corilagin CAS:23094-69-1 Purity:>98%
Medchemexpress, HY-N0462 5mg Corilagin CAS:23094-69-1 Corilagin, a gallotannin, is isolated from Caesalpinia coriaria (Jacq.) Willd. Corilagin inhibits activity of reverse transcriptase of RNA tumor viruses. Corilagin inhibits the growth of Staphylococcus aureus with a MIC of 25 μg/mL. Corilagin shows good anti-tumor activity on hepatocellular carcinoma and ovarian cancer. Corilagin shows a low level of toxicity toward normal cells and tissues. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.