Bioactive Small Molecules
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Filtered Search Results
MEDCHEMEXPRESS LLC KINASE INHIBITOR-1 5MG
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501873846 KINASE INHIBITOR-1 5MG
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SELLECK CHEMICAL LLC ML277-5MG
502341159 ML277-5MG
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SELLECK CHEMICAL LLC YKL 06-061-5MG
502341160 YKL 06-061-5MG
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SELLECK CHEMICAL LLC AZ-33-5MG
502341183 AZ-33-5MG
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GRAINGER INC RETINOIC ACID 5G
502795910 RETINOIC ACID 5G
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Cayman Chemical DSDP, Purity: ≥98%, CAS: 1777807-64-3, 1 mg
A STING agonist; induces expression of an ISG54 luciferase reporter in HepAD38 cells that constitutively express human cGAS and STING; increases IFNB1, TNFA, and IL29 expression in HepG2 cells expressing wild-type human, but not C-terminal truncated human or mouse, STING, as well as in isolated human PBMCs at 50 µM; inhibits yellow fever, dengue, and Zika virus replication in THF fibroblasts at 50 µM
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Medchemexpress LLC Zaprinast | 37762-06-4 | 99.88% | 50 MG
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Zaprinast (M&B 22948) is a selective inhibitor of cGMP-selective Phosphodiesterase (PDE5) that significantly increases cGMP levels in myocytes. It is also a G protein-coupled receptor 35 (GPR35) agonist, activating rat GPR35 strongly and human GPR35 moderately. Zaprinast reduces vessel remodeling through antiproliferative and proapoptotic effects.
- Selective inhibitor of cGMP-selective Phosphodiesterase (PDE5).
- Increases cGMP levels in myocytes.
- G protein-coupled receptor 35 (GPR35) agonist.
- Reduces vessel remodeling through antiproliferative and proapoptotic effects.
- Enhances spatial memory and diminishes exploratory activity in mice.
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Medchemexpress LLC Broxaldine | 3684-46-6 | MFCD00865040 | 99.9% | 5 MG
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Broxaldine (Brobenzoxaldine) is an antiprotozoal agent known to inhibit Clostridium difficile with a MIC value of 4 μM, and it also demonstrates antifungal effects. This product is for research use only.
- Acts as an antiprotozoal agent
- Inhibits Clostridium difficile
- Exhibits antifungal properties
- Purity of 99.88%
- Supplied as a solid, white to off-white in appearance
- Soluble in DMSO at 8.33 mg/mL
- Specific storage conditions for powder and solutions are provided for stability
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Apexbio Technology LLC Alvelestat 848141-11-7 10mM (in 1mL DMSO)
Alvelestat (CAS 848141-11-7) is an orally bioavailable reversible inhibitor of neutrophil elastase (NE) It demonstrates high affinity for human NE exhibiting a Ki of 9 4 nM and over 600-fold selectivity compared to other serine proteases In whole blood cell-based and degranulation assays alvelestat shows pIC50 values of 7 36 7 32 and 7 3 respectively Preclinical studies indicate that alvelestat reduces NE-induced markers of lung injury such as hemoglobin and hydroxyproline levels and attenuates neutrophilic inflammation in models of acute lung injury as well as smoke-induced airway inflammation and emphysema These properties support its use in research on neutrophil-driven pulmonary diseases
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Medchemexpress LLC Animal-free IL-1 beta protein, mouse (His) | 10UG
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Animal-Free IL-1 beta Protein, Mouse (His) is a recombinant mouse interleukin-1 beta (IL-1β) provided in an animal-free production format with a C-terminal His tag. It is supplied in small vial sizes suitable for in vitro research and biochemical characterization; molecular weight is approximately 17-19 kDa by SDS-PAGE.
- Recombinant mouse IL-1 beta with C-terminal His tag.
- Animal-free production to reduce animal-derived contaminants.
- Available in 10 μg and 50 μg sizes for small-scale experiments.
- Approximate molecular weight 17-19 kDa (reducing conditions).
- Datasheet and safety data sheet available for handling and storage information.
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eMolecules 1269181-69-2 | Medchem Express | Nicodicosapent | 2mg | 446268806 | HY-17640 | 449.639 | C28H39N3O2
Ambeed | 18-((25-Dioxopyrrolidin-1-yl)oxy)-18-oxooctadecanoic acid | 100mg | 600838450 | A357864 | 146004-84-4 | 411.539 | C22H37NO6
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eMolecules Building Block Tool
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Cayman Chemical Indolicidin (trifluoroacetate salt), Purity: ≥98%, 5 mg
An antimicrobial peptide; active against MDR-EAEC (MICs = 32 µM for all); active against S. cerevisiae, T. beigelii, and C. albicans (MICs = 5-10, 2.5-5, and 5-10 µM, respectively); reduces viral replication of HIV-1 in MT-2 cells from 67-100 µg/ml; increases survival of MDR-EAEC-infected G. mellonella larvae
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Cayman Chemical RG3039, Purity: ≥98%, CAS: 1005504-62-0, 25 mg
A DcpS inhibitor (IC50 = 0.069 nM); prevents denervation of the NMJ and decreases in NMJ synaptic transmission and myofiber size of the longissimus muscle in a mouse model of Smn1 knockout-induced SMA at 10 mg/kg; improves survival and motor function in the same model
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STEMCELL Technologies Chaetocin, Size: 500 µg
Chaetocin is a fungal mycotoxin, originally produced by Chaetomium species, that inhibits the lysine-specific histone methyltransferases (HMTs) SU(VAR)3-9 (IC₅₀ = 0.8 μM). HMTs are responsible for methylation of histones, thereby affecting heterochromatinization. Chaetocin is also known to inhibit G9a and DIM5 (IC₅₀ = 2.5 μM and 3 μM respectively; Cherblanc et al.; Greiner et al.). Chaetocin also acts as a competitive substrate and inhibitor of the central oxidative stress remediation enzyme thioredoxin reductase-1 (TrxR1; Km = 4.6 μM) more potently than glutathione reductase or thioredoxin (Tibodeau et al.).CANCER RESEARCH· Induces cellular oxidative stress, selectively killing cancer cells and rapidly-proliferating primary cells (Isham et al.; Spannhoff et al.)· Attenuates the growth of glioma xenografts accompanied by an increase in reactive oxygen species (ROS) production (Dixit et al.).
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AdipoGen Emodin (250 mg)
Chemical. CAS: 518-82-1. Formula: C15H10O5. MW: 270.2. Isolated from Polygonum cuspidatum. p56lck protein kinase inhibitor. Competitive casein kinase II (CK2) inhibitor. Anticancer agent with apoptosis inducing with antiangiogenic activity. Antioxidant, vasorelaxant and neuroprotective agent. NF-kappaB activation inhibitor. Inflammasome inhibitor. Potent selective 11beta-HSD1 inhibitor. Improves insulin sensitivity and lipid metabolism. Estrogen receptor ERalpha and ERbeta inhibitor. Inhibits androgen receptor (AR) nuclear translocation and induces AR degradation. VEGFR2, FGFR-1, EGFR, PDGFR-beta and Kit inhibitor. JAK2 inhibitor. Anti-diabetic agent. AMPK activator and PPARgamma agonist. Adipogenesis inhibitor. P2X7 receptor antagonist. Wnt signaling & PI3K/Akt/GSK-3beta pathway modulator.
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