Bioactive Small Molecules

A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.

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5,251 – 5,265 of 60,541 results

5,251

Cayman Chemical Ac-DMQD-CHO (trifluoroacetate salt), Purity: ≥95%, 5 mg

An inhibitor of caspase-3 (IC50 = 39 nM); selective for caspase-3 over caspase-1 and caspase-8 (IC50s = 148 and 1,100 nM, respectively); inhibits camptothecin-induced apoptosis in immortalized human T/C 28a4 chondrocytes and primary human chondrocytes; reduces the number of apoptotic cells, cavitation, and demyelination in a rat model of traumatic injury to the spinal cord at 1 mg/kg

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5,252

Vector Biolabs CHK2 checkpoint homolog (S pombe) Adenovirus (Ad-CHK2/CHEK2)

Ready to use in vivo grade AAV and Adenovirus Ready to use in vivo grade AAV and Adenovirus pre synthesized DNA vector High titer viral vectors 1/EA

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5,253

Cayman Chemical Sergliflozin A, Purity: ≥98%, CAS: 360775-96-8, 5 mg

An SGLT2 inhibitor (Ki = 2.39 nM for the human transporter) and active metabolite of sergliflozin etabonate; selective for SGLT2 over SGLT1 (Ki = 708 nM for the human transporter); co-infusion with glucose reduces maximal renal glucose reabsorption rates in rats

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5,254

Medchemexpress LLC Azido-PEG16-NHS ester | 00-00-0 | 99.9% | 917.00 | C39H72N4O20 | 5 MG

Azido-PEG16-NHS ester is a PEG-based N-hydroxysuccinimide (NHS) ester linker bearing an azide functional group for click chemistry and bioconjugation. It is used to introduce azide handles or to couple with primary amines when building conjugates, linkers, and PROTAC components in chemical biology workflows.

Contains an azide group for CuAAC and SPAAC click reactions.
NHS ester enables rapid coupling to primary amines.
PEG16 spacer provides hydrophilicity and conformational flexibility.
High purity suitable for analytical and preparative use.
Highly soluble in DMSO for concentrated stock solutions.
Stable when stored protected from light at 4°C; in solvent store at -80°C or -20°C.

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5,255

Medchemexpress LLC HY-122537A 5mg Medchemexpress, Arotinolol CAS:68377-92-4 Purity:>98%

Medchemexpress, HY-122537A 5mg Arotinolol CAS:68377-92-4 Arotinolol is a nonselective α/β-adrenergic receptor blocker and a vasodilating β-blocker. Arotinolol also shows potency for inhibiting the binding of the radioligand 125I-ICYP to 5HT1B-serotonergic receptor sites. Arotinolol is an antihypertensive agent for the treatment of a variety of cardiovascular pathologies as well as non-cardiovascular diseases. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.

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5,256

Cayman Chemical N-butyl Pentedrone (hydrochloride), Purity: ≥98%, CAS: 18268-13-8, 5 mg

An analytical reference standard categorized as a cathinone; intended for research and forensic applications

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5,257

Medchemexpress LLC HY-W011094 50mg Medchemexpress, Win 18446 CAS:1477-57-2 Purity:>98%

Medchemexpress, HY-W011094 50mg Win 18446 CAS:1477-57-2 Win 18446 is an orally active testes-specific enzyme ALDH1a2 inhibitor, with an IC50 of 0.3 μM. Win 18446 reversibly inhibits spermatogenesis in many species and inhibits Retinoic acid (HY-14649) biosynthesis from Retinol (HY-B1342) within the testes. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.

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5,258

Medchemexpress LLC Fenclonine (4-Chloro-DL-phenylalanine) | 7424-00-2 | 99.9% | 1 ML

Fenclonine is a selective and irreversible tryptophan hydroxylase inhibitor, which is a rate-limiting enzyme in the biosynthesis of serotonin. Fenclonine can be used in carcinoid syndrome research.

Selective and irreversible tryptophan hydroxylase inhibitor
Can be used in carcinoid syndrome research
Can be used in animal modeling to create insomnia models

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5,259

AdipoGen Pimecrolimus (50 mg)

Chemical. CAS: 137071-32-0. Formula: C43H68ClNO11. MW: 810.45. Synthetic. Pimecrolimus is a immunosuppressive natural ascomycin macrolactam that binds to macrophilin-12 (FKBP-12) and inhibits calcineurin as well as prolyl isomerase (rotamase). Presumably through these actions, it blocks the activation of T cells by allogeneic dendritic cells (IC50=0.55nM) without affecting dendritic cells. Moreover, pimecrolimus suppresses the generation of pro-inflammatory cytokines by T cells, the release of pre-formed inflammatory mediators from mast cells and the activation of eosinophils. These effects support the use of pimecrolimus in countering inflammatory skin diseases, such as atopic dermatitis (eczema) and psoriasis.

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5,260

Cayman Chemical Negamycin (hydrochloride), Purity: ≥80%, 5 mg

An antibiotic; active against a variety of bacteria (3.12-100 µg/ml); stabilizes the interaction between tRNA and ribosomes and decreases the rate of mRNA translation; restores auditory brainstem response to sound tones in an mdx mouse model of DMD at 100 mg/kg

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5,261

Cayman Chemical HIV-1 Integrase Inhibitor, Purity: ≥95%, CAS: 544467-07-4, 5 mg

An inhibitor of HIV-1 integrase strand transfer (IC50s = 0.07 and 0.33 µM in the presence of manganese and magnesium, respectively); selective for strand transfer over 3ʹ DNA processing (IC50 = >70 µM in the presence of either manganese or magnesium); selective for wild-type HIV-1 integrase over HIV-1 integraseF185K/C280S (IC50 = 1.53 µM in the presence of manganese); reduces the secreted levels of p24 in CEM-SS and H9 cells (IC50s = 11 and 7 µM, respectively) without inducing cytotoxicity (CC50s = 600 and 400 µM, respectively)

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5,262

Cayman Chemical ADB-INACA, Purity: ≥98%, CAS: 1887742-42-8, 1 mg

An analytical reference standard categorized as a synthetic cannabinoid metabolite and precursor in the synthesis of synthetic cannabinoids; a metabolite of ADB-PINACA and 5-fluoro ADB-PINACA; intended for research and forensic applications

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5,263

Cayman Chemical Siremadlin, Purity: ≥98%, CAS: 1448867-41-1, 1 mg

A MDM2-p53 protein-protein interaction inhibitor (IC50 = 0.21 nM); selectively inhibits the MDM2-p53 protein-protein interaction over MDM4-p53, YAP1-TEAD4, PCSK9-LDLR, and Bcl-2-Bak interactions in TR-FRET assays (IC50s = 3.3, >150, >50, and >50 µM, respectively); inhibits the growth of SJSA-1 cells (GI50 = 38 nM); induces apoptosis in SJSA-1 cells at 100 nM; induces tumor regression and prevents tumor regrowth in an SJSA-1 rat xenograft model and an HSAX2655 PDX rat liposarcoma model at 27 mg/kg

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5,264

Cayman Chemical 13-Methylberberine (chloride), Purity: ≥98%, CAS: 54260-72-9, 5 mg

A 13-methyl-substituted derivative of berberine; has antibacterial, anti-inflammatory, anti-obesity, and hypercholesterolemic activity; has improved antibacterial activity against S. aureus (MIC = 125 µg/ml) and improved antitumor activity compared to berberine; induces down-regulation of adipocyte differentiation transcription factors; reduces de novo lipid synthesis

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5,265

Medchemexpress LLC N-Benzoyl-β-alanine | 3440-28-6 | 98.7% | 10 G

Betamipron is a chemical compound primarily used in conjunction with Panipenem. It functions by inhibiting Panipenem uptake into the renal tubule, thereby preventing nephrotoxicity. This compound is suitable for various laboratory applications and for the manufacture of substances.

Inhibits Panipenem uptake in the renal tubule.
Prevents nephrotoxicity.
Shows an IC50 of 6 μM for inhibiting Adefovir uptake in OAT1-expressing CHO cells.
Soluble in DMSO at 100 mg/mL.
Soluble in various in vivo protocols at concentrations ≥ 2.5 mg/mL.

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Bioactive Small Molecules

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Medchemexpress LLC Azido-PEG16-NHS ester | 00-00-0 | 99.9% | 917.00 | C39H72N4O20 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC HY-122537A 5mg Medchemexpress, Arotinolol CAS:68377-92-4 Purity:>98% Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC HY-W011094 50mg Medchemexpress, Win 18446 CAS:1477-57-2 Purity:>98% Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Fenclonine (4-Chloro-DL-phenylalanine) | 7424-00-2 | 99.9% | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC N-Benzoyl-β-alanine | 3440-28-6 | 98.7% | 10 G Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Azido-PEG16-NHS ester | 00-00-0 | 99.9% | 917.00 | C39H72N4O20 | 5 MG

Medchemexpress LLC HY-122537A 5mg Medchemexpress, Arotinolol CAS:68377-92-4 Purity:>98%

Medchemexpress LLC HY-W011094 50mg Medchemexpress, Win 18446 CAS:1477-57-2 Purity:>98%

Medchemexpress LLC Fenclonine (4-Chloro-DL-phenylalanine) | 7424-00-2 | 99.9% | 1 ML

Medchemexpress LLC N-Benzoyl-β-alanine | 3440-28-6 | 98.7% | 10 G