Bioactive Small Molecules
Cayman Chemical ANTIBODY LOXO-292 10mg
A RET kinase inhibitor; inhibits phosphorylation of a KIF5B-RET fusion protein expressed in HEK293 cells (IC50 = 4 nM); selectively inhibits proliferation of cancer cells containing RET mutations or gene fusions, including RETM918T-containing MZ-CRC-1 medullary thyroid and CCDC6-RET gene fusion-positive TPC-1 thyroid cancer cells, by 20 to 1,700-fold; improves survival in a CCDC6-RET gene fusion positive orthotopic PDX mouse model of brain cancer at 30 mg/kg
Cayman Chemical ANTIBODY CYM 50308 25mg
A novel agonist of S1P4 (EC50 = 56 nM) that displays 37-fold selectivity against S1P5 (EC50 = 2.1 μM) and no appreciable activity over the S1P1-3 subtypes at concentrations up to 25 μM
Medchemexpress LLC Tiaprofenic acid | 33005-95-7 | MFCD00866089 | 99.9% | 260.31 g/mol | C14H12O3S | 1 ML
Tiaprofenic acid (CAS 33005-95-7) is a nonsteroidal anti-inflammatory compound supplied for research use. It is available as a ready-to-use 10 mM solution in DMSO (1 mL) and in multiple solid pack sizes. The material is high purity and intended for in vitro pharmacology, assay development, and analytical work.
- Ready-to-use 10 mM solution in DMSO, 1 mL volume.
- High purity (~99.9%) suitable for research applications.
- Molecular formula C14H12O3S, molecular weight 260.31 g/mol.
- Available in solid forms for formulation flexibility.
- Intended for research use only; not for human or veterinary use.
Cayman Chemical ANTIBODYS-MG115 10mg
A potent and reversible proteasome inhibitor, targeting the chymotryptic site on the 20S particle (Ki = 21 nM); reduces the degradation of ubiquitin-conjugated proteins in extracts; blocks the degradation of long- and short-lived proteins in intact cells as well as the proteolytic generation of diverse proteins
Medchemexpress LLC HY-118411 500mg , 5-Ethynyl-2'-deoxyuridine CAS:61135-33-9 Purity:>98%
HY-118411 500mg 5-Ethynyl-2'-deoxyuridine CAS: 61135-33-9 5-Ethynyl-2'-deoxyuridine (EdU), a thymidine analogue, is incorporated into cellular DNA during DNA replication and the subsequent reaction of EdU with a fluorescent azide in a “Click” reaction. EdU staining is a fast, sensitive and reproducible method to study cell proliferation. 5-Ethynyl-2'-deoxyuridine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Etoposide | 33419-42-0 | MFCD00869325 | 99.6% | 588.56 g/mol | C29H32O13 | 5 MG
Etoposide (Standard) is an analytical reference material of the chemotherapeutic compound etoposide provided as a high-purity material for research and analytical applications. It is intended for method development, calibration, and qualitative or quantitative assays in laboratories.
Medchemexpress LLC Agatolimod (ODN 2006) | 525625-52-9 | 96.7% | 7699.00 g/mol | C238H314N75O127P23S23 | 5 MG
Agatolimod (ODN 2006) is a class B oligodeoxynucleotide TLR9 agonist containing an optimized CpG motif. It is used as a research reagent to stimulate innate immune responses, induce cytokine production, and support preclinical immuno-oncology studies.
- Sequence: 5'-tcgtcgttttgtcgttttgtcgtt-3'.
- Molecular weight: 7,699 g/mol (manufacturer value).
- Purity: 96.73% (product-level listing).
- Solubility: water ≥125 mg/mL.
- Storage: sealed, away from moisture; short-term 4°C; in solvent -80°C for long term.
- Applications: TLR9 activation, cytokine induction, preclinical immuno-oncology research.
Medchemexpress LLC Malonyl coenzyme A lithium | 108347-84-8 | MFCD00057769 | 98.0% | 860.6 g/mol | C24H38LiN7O19P3S | 5 MG
Malonyl CoA lithium is the lithium salt form of malonyl coenzyme A used as a biochemical reagent to modulate mitochondrial fatty acid metabolism. It functions as an inhibitor of carnitine palmitoyl transferase 1 (CPT1) and is intended for research use in studies of lipid metabolism and energy homeostasis.
- Inhibitor of carnitine palmitoyl transferase 1 (CPT1).
- Modulates fatty acid oxidation in cellular and biochemical assays.
- Provided as the lithium salt to aid solubility in aqueous systems.
- Useful for studies of mitochondrial metabolism and lipid regulation.
- Accompanied by datasheet, certificate of analysis, and safety data sheet.
Medchemexpress LLC Jqad1 | 2417097-18-6 | 98.2% | 932.95 | C48H52F4N6O9 | 5 MG
JQAD1 is a CRBN-dependent proteolysis-targeting chimera (PROTAC) that selectively targets the histone acetyltransferase EP300 for degradation. It suppresses EP300 expression, reduces H3K27ac modification, and can induce apoptosis in cellular models, making it suitable as a research reagent for studying EP300 function and target validation.
- Selective EP300 degradation in cell-based assays.
- CRBN-dependent PROTAC mechanism of action.
- Reduces H3K27ac histone modification associated with EP300 activity.
- Reported high purity suitable for biological research.
- Available in small quantities for experimental screening and validation.
Medchemexpress LLC HY-135853 25mg , Molnupiravir CAS:2492423-29-5 Purity:>98%
HY-135853 25mg Molnupiravir CAS: 2492423-29-5 Molnupiravir (EIDD-2801) is an orally bioavailable prodrug of the ribonucleoside analog EIDD-1931. Molnupiravir has broad spectrum antiviral activity against influenza virus and multiple coronaviruses, such as SARS-CoV-2, MERS-CoV, SARS-CoV. Molnupiravir has the potential for the research of COVID-19, and seasonal and pandemic influenza. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Sotorasib racemate | 5MG
Sotorasib racemate (Compound A) is an orally active racemate of Sotorasib (HY-114277) a covalent inhibitor of KRAS G12C mutant which induces adaptive feedback activation of MAPK pathway Sotorasib racemate also exerts inhibitor activity against KRAS G12C induced cancer and can be applied to cancer research[1]
Medchemexpress LLC N-Fmoc-N'-(azido-PEG4)-L-lysine-PFP ester | 00-00-0 | 95.0% | 807.76 g·mol^-1 | C38H42F5N5O9 | 5 MG
N-Fmoc-N'-(azido-PEG4)-L-lysine-PFP ester is an Fmoc-protected lysine derivative containing an azido-terminated PEG4 spacer and an activated pentafluorophenyl (PFP) ester. It is designed as a PEG-based linker and click-chemistry building block for bioconjugation, enabling efficient coupling and azide-alkyne cycloaddition reactions used in PROTAC and ADC linker synthesis and other synthetic workflows.
- Facilitates copper-catalyzed and strain-promoted azide-alkyne cycloaddition.
- Activated PFP ester enables rapid amide bond formation with amines.
- PEG4 spacer improves solubility and flexibility of conjugates.
- Fmoc protection allows orthogonal deprotection and solid-phase synthesis.
- Suitable for small-quantity research use; typical purity 95%.
Medchemexpress LLC Azide-PEG12-alcohol | 1821464-55-4 | MFCD13184946 | 99.8% | 571.66 g/mol | C24H49N3O12 | 5 MG
Azide-PEG12-alcohol is an azide-functionalized polyethylene glycol (PEG12) linker with a terminal hydroxyl group, formulated for click chemistry and bioconjugation workflows. It enables efficient azide-alkyne cycloaddition and strain-promoted conjugation reactions and is commonly used in linker installation for degraders and conjugates.
- Azide-functionalized PEG12 linker for bioconjugation.
- Terminal hydroxyl group for further modification.
- High purity (99.8%) for research applications.
- Molecular weight approximately 571.66 g/mol.
- Colorless to light yellow liquid; suitable for storage at recommended temperatures.
- Compatible with CuAAC and SPAAC click reactions.