Bioactive Small Molecules
Cayman Chemical ANTIBODY ML-349 1mg
A selective and reversible inhibitor of LYPLA2 (Kis = 230 and >10,000 nM for human recombinant LYPLA2 and LYPLA1, respectively); inhibits LYPLA2 (>95%) with no change in the activity of 25 other serine hydrolases in BW5147 murine T cell hybridoma cells; almost completely inhibits LYPLA2 in HEK293T and mouse T cells and in vivo in murine lung, heart, and kidneys; partially inhibits LYPLA2 in murine brain
Medchemexpress LLC CXCR3 antagonist 1 | 870998-13-3 | 98.6% | 1 MG
CXCR3 antagonist 1 (compound 6c) is a selective and non-cytotoxic CXCR3 antagonist (IC50=0.06 μM). CXCR3 antagonist 1 has potential in researching inflammatory diseases (including inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, and diabetes).
- Selective and non-cytotoxic CXCR3 antagonist
- IC50 = 0.06 μM
- Potential in researching inflammatory diseases (including inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, and diabetes)
Cayman Chemical ANTIBODY CP 466 722 25mg
An ATM kinase inhibitor; inhibits ionizing radiation-induced ATM autophosphorylation and phosphorylation of ATM targets in HeLa cells at 10 μM; selective for ATM over PI3K and PIKK in HFF(hTERT) and A-T(hTERT) fibroblasts, respectively; decreases cell survival in response to ionizing radiation in HeLa cells; cytotoxic to MCF-7 and SKBr-3 breast cancer cells (IC50s = 16.92 and 12.78 μM, respectively)
Medchemexpress LLC H-Tyr-Tyr-OH 10mM 1mL | 1050-28-8 | 344.36 g/mol | C18H20N2O5 | 1 ML
H-Tyr-Tyr-OH (L-tyrosyl-L-tyrosine) is a dipeptide research reagent reported to inhibit angiotensin I-converting enzyme (ACE). It is supplied as a 10 mM solution in DMSO (1 mL) and is also available as solid quantities; reported purity is 99.02% and molecular weight is 344.36 g/mol.
- ACE inhibitor activity useful for blood pressure and enzymatic studies.
- Available as a ready-to-use 10 mM solution in DMSO for quick assays.
- Solid form available for custom formulation and longer-term storage.
- High reported purity (99.02%) suitable for analytical and biological experiments.
- Molecular weight (344.36 g/mol) provided for accurate dosing and calculations.
Cayman Chemical ANTIBODY NVP-CGM097 1mg
An inhibitor of the MDM2-p53 interaction (IC50 = 1.7 nM for human MDM2 in a TR-FRET assay); selective for human MDM2 (Ki = 1.3 nM) over dog, mouse, and rat Mdm2 (Kis = 20.5, 65.9, and 47.4 nM, respectively); selectively inhibits proliferation of AML cells expressing wild-type p53 (IC50s = 50-1,000 nM) over AML cells expressing mutant p53 (IC50s = >1,000 nM); induces tumor regression in a PDX mouse model of AML at 100 mg/kg per day
Selleck Chemical LLC HS-10296 hydrochloride E4886-25MG
HS-10296 hydrochloride(Almonertinib (hydrochloride) HS-10296 HCl) is an irreversible third-generation inhibitor of EGFR tyrosine kinase that demonstrates high selectivity for EGFR-sensitizing mutations T790M resistance mutation It exhibits inhibitory activity against T790M T790M/L858R and T790M/Del19 with IC50 of 0 37 nM 0 29 nM and 0 21 nM respectively It also exhibits anti-tumor activity
Cayman Chemical Centaurea maculosa CnIcIn 5mg
A germacranolide sesquiterpene lactone with diverse biological activities; irreversibly inhibits MurA (IC50s = 16.7 and 10.3 for the E. coli and P. aeruginosa enzymes, respectively) and is active against B. cereus and M. flavus (MICs = 1.25 and 5 UG/ml, respectively); inhibits the growth of MCF-7 and OVCAR-3 cancer cells (GI50s = 37.8 and 37.4 µM, respectively); reduces snake venom-induced paw edema in rats from 2.5-10 mg/kg
Cayman Chemical 3hydroxy3methylglutarylCo 5mg
An intermediate in several metabolic pathways; conversion to mevalonate by HMG-CoA reductase is the rate-limiting first step in the cholesterol biosynthetic pathway; can be cleaved into acetyl-CoA and the ketone body acetoacetate in mitochondria by HMG-CoA lyase; an intermediate in the degradation of leucine
Cayman Chemical BAY 60-2770 5mg
An activator of soluble guanylate cyclase (EC50s = 592 and 573 nM for the α1β1 and α2β1 isoforms, respectively); increases cGMP levels in, and inhibits the aggregation of, collagen- or thrombin-activated washed isolated human platelets, effects that can be potentiated by ODQ; inhibits doxorubicin-induced decreases in the viability of, and increases in ROS levels in, H9c2 cardiomyocytes at 10 µM; decreases pulmonary and systemic arterial pressure in a rat model of monocrotaline-induced pulmonary hypertension; reduces BALF and lung tissue eosinophil infiltration in an ovalbumin-sensitized mouse model of allergic airway inflammation at 1 mg/kg; reverses obesity-induced increases in the frequency of voiding and non-voiding bladder contractions in mice fed a high-fat diet at 1 mg/kg
Medchemexpress LLC HY-119824 5mg Medchemexpress, Trofosfamide CAS:22089-22-1 Purity:>98%
Medchemexpress, HY-119824 5mg Trofosfamide CAS:22089-22-1 Trofosfamide is an orally bioavailable oxazaphosphorine derivative with antineoplastic activity. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical SynthetIc ErysolIn 5mg
An isothiocyanate with anticancer activity; inhibits the proliferation of MCF-7, HeLa, A549, HepG2, and SW480 cells (IC50s = 1.62, 1.12, 5.22, 14, and 8.14 µM, respectively); enhances arsenic trioxide-induced apoptosis and cytotoxicity in HL-60, U937, and K562 cells at 3 µM
Cayman Chemical ANTIBODY EGTA AM 10mg
A cell-permeant acetoxymethyl ester of the calcium chelator EGTA
Cayman Chemical MeclIzIn N-oxIde 5mg
A metabolite of meclizine; a degradation product and potential impurity in commercial preparations of meclizine