Bioactive Small Molecules
Cayman Chemical ANTIBODY TAK-733 1mg
A MEK1 inhibitor (IC50 = 3.2 nM); inhibits ERK phosphorylation in vitro (EC50 = 1.9 nM); inhibits proliferation of A375 and COLO 205 cells (EC50s = 3.1 and 2.1 nM, respectively) and 14 cutaneous melanoma cell lines (IC50s = V600E mutations
Cayman Chemical 4HydroxyIndole3acetIc AcId 5mg
An analytical reference standard categorized as a tryptamine; intended for research and forensic applications
Selleck Chemical LLC Cabazitaxel 5mg 183133-96-2 RPR-116258A, XRP6258, TXD 258
Cabazitaxel (RPR-116258A, XRP6258, TXD 258) is a semi-synthetic derivative of a natural taxoid that kills cancer cells by inhibiting cell division and growth. Cabazitaxel exerts its effects by inhibiting microtubule growth and assembly, processes that are essential for cells to divide. Cabazitaxel induces autophagy via the PI3K/Akt/mTOR pathway. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
TARGETMOL CHEMICALS INC PHA-680632 25MG
Also available in 1 mL, 5 mg, 10 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively. It has 10- to 200-fold higher IC50 for FGFR1, FLT3, LCK, PLK1, STLK2, and VEGFR2/3. Purity 98.2%
Medchemexpress LLC HY-34431 100mg Medchemexpress, Purine CAS:120-73-0 Purity:>98%
Medchemexpress, HY-34431 100mg Purine CAS:120-73-0 Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Propargyl-PEG2-MS | 943726-01-0 | 95.0% | 100 MG
Propargyl-PEG2-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Peg-based protac linker
- Used in the synthesis of protacs
- Click chemistry reagent
- Contains an alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups
Cayman Chemical ANTIBODY ClevudIn 100mg
A β-L-nucleoside analog of thymidine that has antiviral activity; active against HBV in in HepG2/2.15 cells (EC50 = 0.1 µM); reduces virion DNA in the culture supernatant of primary hepatocytes isolated from a duckling model of chronic HBV infection from 0.01-10 µM; reduces serum viral load in a woodchuck model of chronic HBV infection at 3 and 10 mg/kg
Medchemexpress LLC 3-Hydroxybutyric acid sodium | 150-83-4 | 98.0% | 126.09 | 10 G
3-Hydroxybutyric acid sodium (β-Hydroxybutyric acid sodium) is a metabolite that is elevated in type I diabetes. It can modulate the properties of membrane lipids and is capable of interacting with lipids (modeled using a DPPC monolayer) and altering phase behavior at clinical concentrations. It also diminishes the interfacial viscosity of DPPC Monolayers.
- Modulates properties of membrane lipids
- Diminishes interfacial viscosity of DPPC Monolayers
TARGETMOL CHEMICALS INC STING agonist-1 25MG
Also available in 1 mL, 1 mg, 5 mg, 10 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. STING agonist-1 (G10) is a human-specific agent that elicits antiviral activity against emerging Alphaviruses.
Cayman Chemical ANTIBODY BIkInIn 25mg
An inhibitor of several ASK isoforms when given at a concentration of 10 µM, leaving residual kinase activity at less than 10% for ASKα, γ, ε, ζ, η, ι, and 20% for ASKθ, without inhibiting isoforms β and δ; activates signaling induced by brassinosteroids
Cayman Chemical ANTIBODY R-59-022 1mg
An inhibitor of DGK (IC50 = 2.8 µM), increasing DAG-dependent PKC activity; blocks vascular contraction induced by U-46619 (Item No. 16450); induces apoptosis in glioblastoma cells without being toxic to non-cancerous cells; inhibits A. thaliana DGK2 (IC50 = 50 µM) and suppresses root growth but does not affect DGK7 at 50 µM
Medchemexpress LLC HY-129379 1mg Medchemexpress, DC0-NH2 CAS:615538-51-7 Purity:>98%
Medchemexpress, HY-129379 1mg DC0-NH2 CAS:615538-51-7 DC0-NH2 is an effector moiety for ADC and a simplified analog of DC1 with better stability. DC0-NH2 is about 1000-fold more cytotoxic than commonly used anticancer drugs (ex. Doxorubicin). DC0-NH2 can bind to the minor groove of DNA, followed by alkylation of adenine residues by its propabenzindole (CBI) component. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical PhytosphngosInyeast 5mg
A sphingolipid; metabolized to odd-numbered fatty acids with 2-hydroxy palmitic acid as an intermediate; induces cell death in vitro; inhibits carbachol-induced PLD activation in CHO cells transfected with C. elegans muscarinic acetylcholine receptors; essential in the yeast heat stress response