Bioactive Small Molecules

A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.

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6,886 – 6,900 of 60,533 results

6,886

Cayman Chemical N-hexadecanoyl-L-Homoserine lactone, Purity: ≥95%, CAS: 87206-01-7, 5 mg

One of a number of lipophilic, long acyl side-chain bearing AHLs produced by the LuxI AHL synthase homolog SinI involved in quorum-sensing signaling in Sinorhizobium meliloti, a nitrogen-fixing bacterial symbiont of certain legumes; the most abundant AHL produced by the proteobacterium Rhodobacter capsulatus; activates genetic exchange between R. capsulatus cells

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6,887

Cayman Chemical Topiramate, Purity: ≥98%, CAS: 97240-79-4, 50 mg

A sugar sulfamate with anticonvulsant activity; inhibits carbonic anhydrase from intact human erythrocytes (Ki = ~200 μM), as well as blocks sodium and calcium channels, and kainite-induced currents in vitro; increases GABAA receptor-mediated chloride ion flux; inhibits hind-limb tonic-extensor seizures in the maximal electroshock seizure test in mice (ED50 = 39 mg/kg, p.o.)

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6,888

Cayman Chemical Prostaglandin B2, Purity: ≥98%, CAS: 13367-85-6, 5 mg

PGB2 is a non-enzymatic dehydration product resulting from the treatment of PGE2 or PGA2 with strong base. It has weak agonist activity on TP receptors and can increase pulmonary blood pressure in the rabbit at relatively high doses (5 µg/kg).{1301}

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6,889

Cayman Chemical Canertinib (hydrochloride), Purity: ≥98%, CAS: 289499-45-2, 5 mg

An irreversible quinazoline-based HER family tyrosine kinase inhibitor with IC50 values of 0.8, 19, and 7 nM for blocking in vitro activity of EGFR, HER2, and HER4, respectively; inhibits the proliferation of various tumor cells

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6,890

Cayman Chemical VER-49009, Purity: ≥98%, CAS: 558640-51-0, 10 mg

An Hsp90 inhibitor with an IC50 value of 47 nM; induces the expression of HSP27 and Hsp72 while reducing the client proteins c-Raf, B-Raf, survivin, and PRMT5, causing cell cycle arrest and apoptosis

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6,891

Cayman Chemical Cisplatin, CAS: 15663-27-1, 100 mg

A DNA-crosslinking agent; halts the cell cycle at the G2/M phase in vitro; active against murine tumors transplanted into mice and in mouse xenograft models; reduces tumor growth in a squamous cell carcinoma mouse xenograft model at doses of 7.5-12.5 mg/kg; inhibits RecA recombinase of M. tuberculosis (IC50 = 2 µM)

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6,892

Cayman Chemical Aspalatone, Purity: ≥98%, CAS: 147249-33-0, 100 mg

An anti-platelet aggregator (IC50 = 180 µM, in vitro) that prolongs bleeding time significantly in a rodent model of thromboembolism; at 24 mg/kg, generates antioxidant and neuroprotective effects against kainic acid-induced epilepsy in rat hippocampus

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6,893

Cayman Chemical 1-Aminodecylidene bis-Phosphonic Acid, Purity: ≥95%, CAS: 15049-93-1, 5 mg

A potent inhibitor of acid sphingomyelinase (IC50 = 20 nM); selective for acid sphingomyelinase over neutral sphingomyelinase (IC50 = >100 μM); inhibits dexamethasone-induced apoptosis in HepG2 cells

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6,894

Cayman Chemical Alfuzosin (hydrochloride), Purity: ≥98%, CAS: 81403-68-1, 5 mg

A post-synaptic α1-adrenergic receptor antagonist commonly used to improve lower urinary tract symptoms associated with benign prostatic hyperplasia; displays high-affinity with non-selectivity for the three known human α1 adrenoceptors (pKi = 8.0, 8.0, and 8.5 for α1A, α1B, and α1D, respectively)

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6,895

Cayman Chemical PNU 120596, Purity: ≥98%, CAS: 501925-31-1, 25 mg

A positive allosteric modulator of the α7 neuronal nAChR, increasing agonist-evoked calcium flux (EC50 = 216 nM); increases the frequency of ACh-evoked GABAergic postsynaptic currents in rat hippocampal slices and improves the auditory gating deficit caused by amphetamine in rats

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6,896

Enzo Life Sciences Idebenone (100mg). CAS: 58186-27-9

Idebenone is a quinone antioxidant chemically related to ubiquinone. It is a free radical scavenger that protects mitochondrial membranes from lipid peroxidation. It improves overall brain function in various animal models and protective effect on astrocytes is due in part via increased NGF production. Alternative name: 2-(10-Hydroxydecyl)-5,6-dimethoxy-3-methyl-2,5-cyclohexadiene-1,4-dione. Purity: ≥98% (HPLC). Long Term Storage: Ambient.

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6,897

Enzo Life Sciences E-4031 . dihydrochloride (5mg). CAS: 113558-89-7

Potent and selective blocker of the inactivating inward rectifying potassium current IKR (HERG channel). Class III antiarrythmic agent with differential atrial vs. ventricular activity. Alternative name: 4'-[[1-[2-(6-methyl-2-pyridyl)ethyl]-4-piperidinyl]carbonyl]-methanesulfonanilide. Purity: ≥98% (HPLC). Solubility: Soluble in water (100mg/ml) or DMSO. Long Term Storage: Ambient.

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6,898

Enzo Life Sciences KRN7000 (1 mg). CAS: 158021-47-7

KRN7000 is a synthetic analog of α-galactosylceramide and the marine natural product agelasphin. It is a specific ligand for human and mouse NKT cells and remains the best studied ligand of the lipid-binding MHC class I-like protein CD1d. It protects against LPS-induced shock and displays potent antitumor activity in various in vivo models. Alternative name: α-Galactosylceramide, α-Gal-Cer, (2S,3S,4R)-1-O-(α-D-Galactosyl)-N-hexacosanoyl-2-amino-1,3,4-octadecanetriol. Purity: ≥98% (TLC). Solubility: KRN7000 is inherently an extremely hydrophobic molecule, therefore, almost all the methods for solubilizing this material in primarily aqueous media will contain at least some detergent. For cell culture or other in vivo models, it is recommended that the KRN7000 be initially dissolved in a 2:1 mixture of chloroform and methanol. This solution should then be aliquoted into amounts suitable for a day’s use into glass vials. Long Term Storage: -20°C.

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6,899

American Research Products Inc AMERICAN RESEARCH PRODUCTS INC

5000632425 MOUSE SIRT5 ELISA KIT

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6,900

Cayman Chemical UK 383367, Purity: ≥98%, CAS: 348622-88-8, 10 mg

A potent, selective inhibitor of BMP1 (IC50 = 44 nM); effective in a cell-based model of collagen deposition is very effective at penetrating human skin in vitro

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Bioactive Small Molecules

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