Bioactive Small Molecules

A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.

Search Within Results

7,186 – 7,200 of 60,533 results

7,186

Cayman Chemical ANTIBODY S63845 500ug

An Mcl-1 inhibitor (Ki = 0.19 nM); induces cell death in multiple myeloma, leukemia, and lymphoma cell lines (IC50s = via mitochondrial apoptosis; acts synergistically with trametinib, lapatinib, PLX4032, and erlotinib to reduce proliferation of SK-MEL-2, BT474, A2058, and PC9 cells, respectively; reduces tumor volume in a MV4-11 acute myeloid leukemia mouse xenograft model in a dose-dependent manner

Pricing & Availability

7,187

TARGETMOL CHEMICALS INC ASTAXANTHIN 50MG

Also available in 2 mg 5 mg 10 mg 25 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. Astaxanthin (trans-Astaxanthin) is a keto-carotenoid in the terpenes class of chemical compounds. It is classified as a xanthophyll but it is a carotenoid with no vitamin A activity. It is present in most red-colored aquatic organisms. Astaxanthin has shown to mediate anti-oxidant and anti-inflammatory actions. It may be found in fish feed or some animal food as a color additive. purity: 99%

Pricing & Availability

7,188

Cayman Chemical ARN24139, Purity: ≥98%, CAS: 2699768-78-8, 10 mg

A topoisomerase II poison (IC50 = 7.3 µM); inhibits proliferation of DU145, HeLa, and A549 cells (IC50s = 4.7, 3.8, and 3.1 µM, respectively)

Pricing & Availability

7,189

Cayman Chemical TC-FPR 43, Purity: ≥98%, CAS: 903895-98-7, 5 mg

An agonist of FPR1 and FPR2; induces calcium flux in CHO cells expressing human FPR2, Gα15, and aequorin (EC50 = 0.044 µM) and in CHO-K1 cells expressing either human FPR1, human FPR2, mouse Fpr1, or mouse Fpr2, Gα16, and aequorin in a concentration-dependent manner; inhibits fMLP- or IL-8-induced neutrophil migration (IC50s = 0.64 and 0.24 µM, respectively); reduces PGE2- and LTB4-induced ear swelling in mice at 50 mg/kg

Pricing & Availability

7,190

Cayman Chemical Chelidonine, Purity: ≥98%, CAS: 476-32-4, 5 mg

A benzophenanthridine alkaloid; induces Bcl-2- and caspase-dependent apoptosis in HepG2 human liver carcinoma cells (LD50 = 12 µM) and in Jurkat human T cells at 1 µM; downregulates hTERT expression, reduces telomerase activity, and induces cell senescence in HepG2 cells

Pricing & Availability

7,191

Cayman Chemical LSN2814617, Purity: ≥98%, CAS: 1313498-08-6, 25 mg

A positive allosteric modulator of mGluR5 receptors; potentiates glutamate-induced calcium mobilization in MCB3901 cells expressing human mGluR5 (EC50 = 52 nM); increases rat hippocampal mGluR5 receptor occupancy (ED50 = 13 mg/kg); increases wakefulness and decreases NREM and REM sleep in rats at 0.3, 1, and 3 mg/kg

Pricing & Availability

7,192

Selleck Chemical LLC Fmoc-Leu-d10 E8240-5MG

Fmoc-Leu-d10 is the deuterated form of Fmoc-Leu-OH Fmoc-Leu-OH is an intermediate used to protect leucine in solid phase peptide synthesis The peptide drugs synthesized by Fmoc-Leu-OH may have activities such as regulating insulin sensitivity

Pricing & Availability

7,193

Cayman Chemical FX1, Purity: ≥95%, CAS: 1426138-42-2, 1 mg

A BCL6 inhibitor (IC50 = ~35 μM); selective for BCL6 over a panel of 50 kinases at 10 μM; reduces recruitment of the BCL6 corepressor proteins SMRT and BCOR to the BCL6 target loci CDKN1A, CD69, and CXCR4 in a ChIP assay at 50 μM; represses growth of Farage, SU-DLH-6, DOHH-2, OCI-Ly7, RCK8, SU-DHL-4, OCI-Ly1, and SC-1 BCL6-dependent cell lines (GI50s = 16-54 μM); reduces tumor volume in an HBL-1 large B cell lymphoma mouse xenograft model at 50 mg/kg

Pricing & Availability

7,194

Cayman Chemical IT-901, Purity: ≥98%, CAS: 1584121-99-2, 50 mg

An inhibitor of the NF-κB subunit c-Rel; inhibits NF-κB DNA binding (IC50 = 0.1 µM); reduces TNF-α-induced NF-κB activity (IC50 = 4 µM); decreases proliferation of ABC and GCB DLBCLL cells at 3 µM; increases HO-1 expression and ROS production in mitochondria of DLBCL cells but not normal leukocytes; increases survival in a mouse model of GVHD at 24 mg/kg every other day beginning eight days after HSCT; reduces tumor growth in mouse xenograft models of EBV-induced B cell lymphoma, CLL, and Richter syndrome

Pricing & Availability

7,195

Medchemexpress LLC DSR-141562 | 2007975-22-4 | 100.0% | 414.42 | 50 MG

DSR-141562 is a novel, orally active, and selective brain-penetrant phosphodiesterase 1 (PDE1) inhibitor. It shows preferential selectivity for human PDE1B with an IC50 of 43.9 nM, and IC50 values for human PDE1A and 1C are 97.6 and 431.8 nM, respectively. It can be used for the study of positive symptoms, negative symptoms, and cognitive impairments associated with schizophrenia.

Novel, orally active, and selective brain-penetrant phosphodiesterase 1 (PDE1) inhibitor.
Shows preferential selectivity for human PDE1B.
Applicable for studying positive symptoms, negative symptoms, and cognitive impairments related to schizophrenia.

Pricing & Availability

7,196

Cayman Chemical RMC-4550, Purity: ≥98%, CAS: 2172651-73-7, 5 mg

A SHP-2 inhibitor (IC50 = 1.55 nM); selective for SHP-2 over a panel of 14 additional protein phosphatases and a panel of 468 protein kinases at 10 µM; inhibits tumor ERK phosphorylation in a KYSE-520 human esophageal cancer xenograft model in a dose-dependent manner

Pricing & Availability

7,197

Cayman Chemical AR-7, Purity: ≥98%, CAS: 80306-38-3, 1 mg

A RARα antagonist; increases chaperone-mediated autophagy in an RARα-dependent manner, increases LAMP-2A expression, and inhibits paraquat-induced decreases in cell viability in mouse fibroblasts at 20 μM; selectively cytotoxic to HepG2 cells grown under hypoxic over normoxic conditions (IC50s = 10 and >1,000 μM, respectively)

Pricing & Availability

7,198

Medchemexpress LLC 5,5'-Oxybis(isobenzofuran-1,3-dione) | 1823-59-2 | 99.5% | 310.22 | 100 G

5,5'-Oxybis(isobenzofuran-1,3-dione) is a drug intermediate for the synthesis of various active compounds. This product is intended for research use only.

Functions as a drug intermediate
Suitable for synthesis of various active compounds
Intended for research use only

Pricing & Availability

7,199

Medchemexpress LLC Tissue Type Plasminogen Activator Antibody (YA3206) | 100 UL

Tissue Type Plasminogen Activator Antibody (YA3206) is a rabbit-derived, non-conjugated IgG monoclonal antibody that targets Tissue Type Plasminogen Activator (tPA). tPA is an enzyme that converts plasminogen into active plasmin by cleaving a specific Arg-Val bond. It plays key roles in tissue remodeling, degradation, cell migration, and various physiopathological processes, including contributing to polyspermy prevention during oocyte activation. This antibody is for research use only.

Host: Rabbit
Clonality: Monoclonal
Species reactivity: Human, mouse, rat
Purity: Affinity chromatography
Molecular weight: 63 kDa
Applications: WB, IHC-P
Storage: Stored at -20°C for 1 year; avoid repeated freeze / thaw cycles

Pricing & Availability

7,200

Medchemexpress LLC 3-(5-((((1-(5-(3-chlorophenyl)-3-(trifluoromethyl)pyridin-2-yl)piperidin-4-yl)methyl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6... | 99.4% | 740.09 | 25 MG

MYC degrader 1 TFA (compound A80.2HCl) is an orally available MYC molecular glues degrader with anti-tumor activity. It restores pRB1 protein activity and re-establishes sensitivity of MYC overexpressing cancer cells to CDK4/6 inhibitors.

Orally available MYC molecular glues degrader
Anti-tumor activity
Restores pRB1 protein activity
Re-establishes sensitivity of MYC overexpressing cancer cells to CDK4/6 inhibitors

Pricing & Availability

Bioactive Small Molecules

Filtered Search Results

Narrow Results

Medchemexpress LLC DSR-141562 | 2007975-22-4 | 100.0% | 414.42 | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 5,5'-Oxybis(isobenzofuran-1,3-dione) | 1823-59-2 | 99.5% | 310.22 | 100 G Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Tissue Type Plasminogen Activator Antibody (YA3206) | 100 UL Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC DSR-141562 | 2007975-22-4 | 100.0% | 414.42 | 50 MG

Medchemexpress LLC 5,5'-Oxybis(isobenzofuran-1,3-dione) | 1823-59-2 | 99.5% | 310.22 | 100 G

Medchemexpress LLC Tissue Type Plasminogen Activator Antibody (YA3206) | 100 UL