Protein Modification Reagents
Medchemexpress LLC Dbco-peg4-acetic-val-cit-pab | 98.2% | 855.97 | C45H57N7O10 | 100 MG
Cleavable 4-unit PEG antibody-drug conjugate (ADC) linker that contains a DBCO functional group for strain-promoted alkyne-azide cycloaddition (SPAAC). It is used to conjugate payloads to azide-containing molecules in ADC and bioconjugation workflows.
- Cleavable Val-Cit-PAB linker for cathepsin B-mediated payload release.
- DBCO moiety enables copper-free SPAAC with azide-functionalized partners.
- PEG4 spacer improves solubility and reduces steric hindrance.
- Available in multiple pack sizes, including 100 MG for synthesis scale-up.
- High reported purity suitable for synthetic bioconjugation applications.
Medchemexpress LLC N-Boc-PEG5-bromide | 1392499-32-9 | MFCD31536756 | 98.0% | 400.31 g/mol | C15H30BrNO6 | 500 MG
N-Boc-PEG5-bromide is a Boc-protected polyethylene glycol (PEG5) alkyl bromide linker used as a building block in medicinal chemistry for PROTAC and ADC linker synthesis. It provides an orthogonally protected amine and a terminal bromide for downstream coupling and substitution reactions. Supplied with high reported purity, it is intended for research use under appropriate laboratory conditions.
- Boc-protected amine for orthogonal deprotection.
- Five-unit PEG spacer provides flexibility and solubility.
- Terminal bromide enables nucleophilic substitution (SN2) chemistry.
- Reported purity approximately 98.0%.
- Suitable for assembly of PROTAC and ADC linkers.
- Recommended cold storage to preserve stability.
Cambridge Isotope Laboratories GLYCAN-O6-13C-GAL4 (GALACTOSE-13C6, 99%), 500 PMOL
GLYCAN-O6-13C-GAL4 (GALACTOSE-13C6, 99%), 500 PMOL
Medchemexpress LLC Dbco-PEG4-VC-PAB-MMAE | 2129164-91-4 | 99.2% | 1658.03 g/mol | C88H128N12O19 | 50 MG
Drug-linker conjugate used for antibody-drug conjugate (ADC) research that couples a DBCO clickable handle and a PEG4 spacer to a valine-citrulline cleavable linker with a p-aminobenzyl self-immolative spacer and the cytotoxic payload monomethyl auristatin E (MMAE). Supplied as a solid for conjugation via strain-promoted alkyne-azide cycloaddition (SPAAC) to azide-functionalized biomolecules.
- Enables SPAAC click conjugation to azide-containing biomolecules.
- Includes Val-Cit cleavable linker for intracellular payload release.
- Contains PEG4 spacer to improve hydrophilicity and reduce aggregation.
- Provided as a solid suitable for storage and DMSO formulation.
- High reported purity for reliable conjugation performance.
Apexbio Technology LLC EdU Flow Cytometry Assay Kit (Cy3), 100 tests
EdU Flow Cytometry Assay Kit (Cy3) is a sensitive and reliable way to detect and quantify cell proliferation in mammalian cells. It is optimized for flow cytometry. It is a better alternative to traditional BrdU (bromodeoxyuridine). Other sizes are also available. Please inqury us for quote.
Medchemexpress LLC Ethanol, 2-[2-[2-[2-[(2,4-dinitrophenyl)amino]ethoxy]ethoxy]ethoxy]- | 1807520-99-5 | 97.9% | C14H21N3O8 | 250 MG
DNP-PEG4-alcohol is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs are compounds that contain two different ligands connected by a linker; one targets an E3 ubiquitin ligase and the other targets a protein of interest. This mechanism exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker.
- Used in the synthesis of PROTACs.
- Facilitates selective degradation of target proteins.
Medchemexpress LLC Biotin-PEG4-Amide-C6-Azide | 1006592-62-6 | 99.1% | C27H49N7O7S | 25 MG
Biotin-PEG4-Amide-C6-Azide is a PEG-based PROTAC linker used in the synthesis of PROTACs. This click chemistry reagent contains an Azide group, facilitating copper-catalyzed azide-alkyne cycloaddition (CuAAc) with Alkyne group molecules. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN group molecules.
- PEG-based PROTAC linker
- Click chemistry reagent with azide group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC)
Medchemexpress LLC Biotin-PEG4-hydrazide | 756525-97-0 | 99.9% | C21H39N5O7S | 25 MG
Biotin-PEG4-hydrazide is a biotin-labeled, PEG-based PROTAC linker. It is used in the synthesis of Proteolysis-targeting chimeras (PROTACs), which exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Biotin-labeled
- PEG-based PROTAC linker
- Utilized in PROTAC synthesis
- Exploits intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
eMolecules Hydroxy-PEG3-CH2CO2tBu | 518044-31-0 | MFCD27977510 | 1g
Apollo Scientific | Hydroxy-PEG3-CH2CO2tBu | 1g | 591806870 | BIPG1437 | | 518044-31-0 | MFCD27977510 | 264.318 | C12H24O6
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Broadpharm Bis-PEG9-NHS ester| 100MG| CAS# 1008402-79-6
Bis-PEG9-NHS ester| 100MG| CAS# 1008402-79-6
Supply Solutions Roche - Trypsin,Sequencing Grade,modified; from bovine pancreas; pkg of 4 x 100 ug (11418033001) pkg of 4 x 25 ug (11418025001)
Roche - Trypsin,Sequencing Grade,modified; from bovine pancreas; pkg of 4 x 100 ug (11418033001) pkg of 4 x 25 ug (11418025001)
Medchemexpress LLC Amino-PEG4-CH2COOH | 195071-49-9 | ≥98.0% | 5 G
Amino-PEG4-CH2COOH is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It also serves as a non-cleavable 4-unit PEG ADC linker for the creation of antibody-drug conjugates (ADCs).
- Used in the synthesis of PROTACs
- Functions as a non-cleavable 4-unit PEG ADC linker
- PROTACs degrade target proteins using the ubiquitin-proteasome system
- ADCs consist of an antibody linked to an ADC cytotoxin