Protein Modification Reagents
Medchemexpress LLC Propargyl-PEG4-sulfonic acid | 1817735-29-7 | 98.0% | 296.34 | 5 G
Propargyl-PEG4-sulfonic acid is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring an Alkyne group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with Azide-containing molecules.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an Alkyne group
- Facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc)
Medchemexpress LLC N3-PEG11-CH2CH2Br | 2098982-00-2 | MFCD32696701 | 99.8% | 634.56 g/mol | C24H48BrN3O11 | 50 MG
N3-PEG11-CH2CH2Br is a polyethylene glycol (PEG11) linker with an azide (N3) terminus and a bromide-functionalized ethylene spacer. It is a hydrophilic, viscous liquid used in bioconjugation and click-chemistry workflows to improve aqueous solubility and provide a reactive bromide handle for further modification.
- Azide-terminated PEG11 linker for click chemistry.
- Bromide-functionalized ethylene spacer provides a reactive handle.
- Hydrophilic PEG spacer increases solubility in aqueous media.
- High purity suitable for research applications.
- Recommended storage conditions maintain stability.
Medchemexpress LLC Amino-PEG10-OH | 129449-09-8 | MFCD28385478 | >98.0% | 457.56 g/mol | C20H43NO10 | 250 MG
Amino-PEG10-OH is a 10-unit polyethylene glycol (PEG) linker bearing a terminal primary amine, used as a non-cleavable spacer in bioconjugation. It is commonly employed in the synthesis of antibody-drug conjugates (ADCs) and proteolysis targeting chimeras (PROTACs) to provide hydrophilic spacing and a reactive site for payload attachment. The material is typically supplied as a white to off-white solid (CAS 129449-09-8) with a molecular weight of 457.56 g/mol.
- Non-cleavable 10-unit PEG spacer suitable for ADC and PROTAC chemistry.
- Terminal primary amine enables straightforward conjugation to activated esters and acids.
- Hydrophilic spacer improves solubility and reduces steric hindrance between conjugated components.
- High purity suitable for research applications.
- Available in laboratory quantities such as 250 mg for small-scale synthesis.
Medchemexpress LLC Carbonic acid, 2,5-dioxo-1-pyrrolidinyl 1-[5-methoxy-2-nitro-4-[(4-oxo-8,11,14,17-tetraoxa-5-aza... | 1802907-98-7 | 95.0% | 653.63 g/mol | C29H39N3O14 | 50 MG
PC Alkyne-PEG4-NHS ester is a cleavable 4-unit PEG linker containing an alkyne group and an N-hydroxysuccinimide (NHS) ester, used for bioconjugation and click-chemistry applications such as antibody-drug conjugate synthesis.
- Cleavable 4-unit polyethylene glycol spacer for improved solubility.
- Alkyne functional group for copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- NHS ester reactive toward primary amines for efficient conjugation.
- Typical purity 95.0%.
- Storage: pure form -20°C; in solvent -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC TCO-PEG4-VC-PAB-MMAE | 2758671-45-1 | 99.3% | 1522.91 | C78H127N11O19 | 10 MG
TCO-PEG4-VC-PAB-MMAE is a drug-linker conjugate intended for use in antibody-drug conjugate (ADC) assembly and click-chemistry bioconjugation workflows. It combines a trans-cyclooctene (TCO) click handle, a PEG4-Val-Cit-PAB cleavable linker, and the cytotoxic payload MMAE to enable site-selective conjugation and intracellular release of the payload.
- Provides a trans-cyclooctene (TCO) handle for inverse electron-demand Diels-Alder reactions with tetrazines.
- Contains a PEG4-Val-Cit-PAB cleavable linker for enzymatic payload release.
- Conjugated to MMAE to supply a potent cytotoxic payload for ADC research.
- High purity (99.3%) suitable for research and bioconjugation workflows.
- Characterized by molecular weight 1522.91 and formula C78H127N11O19.
Medchemexpress LLC m-PEG12-Thiol | 2413368-61-1 | 95.0% | C25H52O12S | 50 MG
m-PEG12-Thiol is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs are compounds that leverage the intracellular ubiquitin-proteasome system for the targeted degradation of proteins. These molecules consist of two distinct ligands, one binding to an E3 ubiquitin ligase and the other to a target protein, connected by a linker.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Facilitates targeted protein degradation
Sigma Aldrich Fine Chemicals Biosciences Pronase from Streptomyces griseus |
Pronase from Streptomyces griseus |
Medchemexpress LLC Nhpi-peg4-c2-nhs ester | 1415328-95-8 | MFCD28155511 | 98.9% | 508.48 | C23H28N2O11 | 50 MG
NHPI-PEG4-C2-NHS ester is an NHS-activated PEGylated linker reagent used in the synthesis of antibody-drug conjugates (ADCs). The molecule provides an activated ester for efficient coupling to primary amines and a PEG4 spacer that improves solubility and linker flexibility, supplied as a viscous liquid with high purity for research applications.
- Activated NHS ester for rapid conjugation to primary amines.
- Peg4 spacer improves aqueous solubility and linker flexibility.
- Suitable for construction of antibody-drug conjugates.
- High purity, viscous liquid form appropriate for research use.
- Store at -20°C in pure form; stability is reduced in solvent.
Medchemexpress LLC Dbco-peg4-ggfg-dxd | 2694856-51-2 | MFCD22575025 | 98.4% | 1375.47 | C72H79FN10O17 | 5 MG
DBCO-PEG4-GGFG-Dxd is an agent-linker conjugate used in antibody-drug conjugate (ADC) research that incorporates a cleavable GGFG linker and a DBCO-PEG4 moiety to enable strain-promoted alkyne-azide cycloaddition (SPAAC) click chemistry for conjugation to azide-containing molecules.
- Provides a payload-linker suitable for ADC construction.
- Enables copper-free SPAAC click chemistry with azide-functionalized partners.
- Contains a cleavable GGFG linker for payload release.
- Supplied as an off-white to light yellow solid for ease of handling.
- Stable when stored protected from light at -20°C; in solvent stability is extended at -80°C.
Medchemexpress LLC m-PEG5-succinimidyl carbonate | 1058691-00-1 | MFCD30828680 | 98.0% | 393.39 g/mol | C16H27NO10 | 100 MG
m-PEG5-succinimidyl carbonate is a non-cleavable, 5-unit polyethylene glycol (PEG) succinimidyl carbonate linker with an NHS-type carbonate reactive group for conjugation to primary amines. It is commonly used in synthesis of antibody-drug conjugates (ADCs), PROTAC linkers, and for PEGylation of amine-containing molecules. Typical specifications: purity 98.0%, molecular weight 393.39 g/mol, formula C16H27NO10, CAS 1058691-00-1.
- Provides an NHS-type carbonate reactive group for efficient amine conjugation.
- Non-cleavable 5-unit PEG spacer increases solubility and spacing between conjugated moieties.
- High purity (98.0%) suitable for research-grade conjugation chemistry.
- Available in small pack sizes to support synthetic workflows.
- Stable when stored frozen; follow solvent storage recommendations for solutions.
STA PHARMACEUTICAL US LLC FmocNH-PEG8-CH2CH2COOH | 25 g | CAS 756526-02-0 | MDL MFCD11041143
FmocNH-PEG8-CH2CH2COOH is a Amino Acid reagent (Subcategory: PEG AA) sold by WuXi TIDES. Offered in 25 g. Store at 4 °C. SDS available for reference.
Specifications
- CAS: 756526-02-0
- MDL: MFCD11041143
- InChIKey: VYXGUCLTEWCVRY-UHFFFAOYSA-N
- Molecular Weight: 663.761
- Molecular Formula: C34H49NO12
- Purity: ≥95%
- Container Type: 125 mL HDPE
- Pack Size: 25 g
- Net Weight: 25 g
- Gross Weight: 54.3 g
- Commodity Code: 29242970
- Country Of Origin: China
- IUPAC: 1-(9H-fluoren-9-yl)-3-oxo-2,7,10,13,16,19,22,25,28-nonaoxa-4-azahentriacontan-31-oic acid
- SMILES: O=C(CCOCCOCCOCCOCCOCCOCCOCCOCCNC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)O