Protein Modification Reagents
Medchemexpress LLC m-PEG2-CH2CH2COOH | 209542-49-4 | MFCD20646047 | 97.0% | 192.21 g/mol | C8H16O5 | 500 MG
m-PEG2-CH2CH2COOH is a PEG2-based linker bearing a terminal carboxylic acid used as a spacer in the synthesis of PROTACs and for bioconjugation applications.
- Molecular formula C8H16O5 and molecular weight 192.21 g/mol.
- CAS number 209542-49-4.
- Typical purity 97.0% (NMR).
- Available in 250 mg, 500 mg, 1 g, 5 g, and larger sizes by quotation.
- Intended for use as a spacer/linker in medicinal chemistry and PROTAC synthesis.
- Store cold (examples indicate -20°C for long-term storage).
Medchemexpress LLC M-PEG5-CH2CH2COOH | 1347750-72-4 | MFCD20926383 | >95.0% | 324.37 | C14H28O8 | 5 G
m-PEG5-CH2CH2COOH is a methyl-capped polyethylene glycol (PEG5) linker terminating in a carboxylic acid. It is used as a short PEG spacer for conjugation in PROTAC and ADC synthesis, providing solubility and a reactive terminal carboxyl for coupling reactions.
- Methyl-capped PEG5 spacer with terminal carboxylic acid.
- Designed for use in PROTAC and ADC linker synthesis.
- Typical purity ≥95.0%.
- Molecular weight 324.37 and formula C14H28O8.
- Available in small-scale packages including 5 g.
- Store pure material at -20°C for long-term stability.
Hampton Research HR2-428-43/Additive Screen 43 (D07), 1.0 ml - 1.0 M Guanidine hydrochloride
HR2-428-43/Additive Screen 43 (D07), 1.0 ml - 1.0 M Guanidine hydrochloride. Please note items from this supplier are non-returnable.
Medchemexpress LLC Propargyl-PEG4-GGFG-DXd | 2762518-94-3 | 100.0% | 1083.12 g/mol | C54H63FN8O15 | 50 MG
Propargyl-PEG4-GGFG-DXd is a drug-linker conjugate for antibody-drug conjugate (ADC) research that combines a cleavable GGFG-PEG4 linker with a propargyl reactive group and the DNA topoisomerase I inhibitor DXd as the payload. This compound is supplied for research use only and is intended for conjugation and ADC development studies.
- High stated purity suitable for research applications
- Contains a propargyl functional group for click chemistry conjugation
- Includes a cleavable GGFG linker designed for payload release
- Payload is a topoisomerase I inhibitor (DXd) for cytotoxic activity
- Available in multiple pack sizes for small-scale research
- Supplied for research use only, not for human use
Medchemexpress LLC Mal-PEG2-NHS ester | 1433997-01-3 | MFCD24539465 | 98.6% | 354.31 | C15H18N2O8 | 5 G
Mal-PEG2-NHS ester is a non-cleavable antibody-drug conjugate (ADC) linker that contains a maleimide thiol-reactive group, a two-unit polyethylene glycol (PEG2) spacer, and an N-hydroxysuccinimide (NHS) ester for amine coupling. It is supplied as a viscous, colorless to off-white liquid and is used for thiol-to-amine bioconjugation in ADC construction and other protein labeling applications.
- Non-cleavable maleimide-NHS bifunctional linker.
- 2-unit PEG spacer improves solubility and reduces aggregation.
- Thiol-reactive maleimide enables cysteine conjugation.
- NHS ester enables coupling to primary amines.
- High purity (≈98.6%) suitable for research applications.
- Available in multiple pack sizes, including 5 G.
- Recommended storage: -20°C (pure), -80°C (in solvent) per supplier storage instructions.
Medchemexpress LLC Amino-PEG5-CH2COOH | 141282-35-1 | ≥97.0% | 100 MG
Amino-PEG5-CH2COOH is a PEG-based PROTAC linker primarily used in the synthesis of PROTACs. It leverages the intracellular ubiquitin-proteasome system to facilitate the selective degradation of target proteins.
- Peg-based protac linker
- Utilized in the synthesis of protacs
- Consists of two distinct ligands connected by a linker
- Targets E3 ubiquitin ligase and protein of interest
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- For research use only
Medchemexpress LLC Propargyl-PEG4-Tos | 875770-32-4 | 99.3% | 500 MG
Propargyl-PEG4-Tos is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It also functions as a cleavable ADC linker for synthesizing antibody-drug conjugates (ADCs) and serves as a click chemistry reagent containing an Alkyne group. This allows it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- PEG-based PROTAC linker
- Cleavable ADC linker
- Click chemistry reagent with an alkyne group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc)
Medchemexpress LLC Fmoc-NH-PEG11-CH2CH2COOH | 3076038-46-2 | 98.5% | 100 MG
Fmoc-NH-PEG11-CH2CH2COOH is a PEG-based PROTAC linker. It is primarily used in the synthesis of PROTACs, which are molecules designed to degrade target proteins by leveraging the intracellular ubiquitin-proteasome system. This product is intended for research use only.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- For research use only
Medchemexpress LLC Bromoacetamido-PEG4-acid | 1807518-67-7 | MFCD28950779 | 96.8% | 386.24 g/mol | C13H24BrNO7 | 100 MG
Bromoacetamido-PEG4-acid is a PEG-based linker containing a bromoacetamido reactive group and a four-unit polyethylene glycol (PEG4) spacer. It is used in the synthesis of PROTAC molecules and as a cleavable linker for antibody-drug conjugates (ADCs). The compound is supplied as a colorless to light yellow liquid and is available in multiple package sizes with defined storage conditions.
Medchemexpress LLC N3-PEG4-C2-NHS ester | 944251-24-5 | 98.9% | 5 G
N3-PEG4-C2-NHS ester is a non-cleavable 4-unit PEG linker utilized in the synthesis of antibody-drug conjugates (ADCs). It functions as a click chemistry reagent, containing an Azide group. This allows it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules that contain Alkyne groups. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups.
- Non-cleavable 4-unit PEG linker
- Used in synthesis of antibody-drug conjugates (ADCs)
- Functions as a click chemistry reagent
- Contains an Azide group
- Participates in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc)
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
Medchemexpress LLC Mal-PEG4-NHS ester | 1325208-25-0 | 99.4% | 442.42 g·mol⁻1 | C19H26N2O10 | 1 G
Mal-PEG4-NHS ester is a PEG-based bifunctional linker containing a maleimide group and an N-hydroxysuccinimide (NHS) ester that enables conjugation between thiol-containing and amine-containing molecules. It is commonly used in antibody-drug conjugate (ADC) linker chemistry, quantum dot conjugation, and linking PEGylated liposomes.
- Non-cleavable maleimide-NHS ester linker suitable for thiol-to-amine conjugation.
- Molecular weight approximately 442.42 g·mol⁻1.
- Chemical formula C19H26N2O10.
- High purity (≈99.4%) as supplied.
- Soluble in DMSO (100 mg/mL); hygroscopic-use freshly opened DMSO and sonication as needed.
- Storage: -20°C for solid stock (up to 3 years); in solvent: -80°C (6 months), -20°C (1 month).
- Available in laboratory-scale quantities including 1 g packaging.