Protein Modification Reagents
Medchemexpress LLC NH2-C5-PEG4-N3-L-lysine-PEG3-N3 | 99.4% | 619.71 g/mol | C25H49N9O9 | 100 MG
A cleavable 7-unit polyethylene glycol (PEG) linker with an amino terminus and azide functionality used for antibody-drug conjugate (ADC) synthesis and bioconjugation workflows.
- Cleavable 7-unit PEG linker suitable for ADC synthesis.
- Contains amino (NH2) and azide (N3) functional groups for conjugation.
- High purity: 99.4%.
- Molecular weight: 619.71 g/mol.
- Soluble ≥ 100 mg/mL in water for aqueous conjugations.
- Available in multiple pack sizes, including 100 MG.
Medchemexpress LLC M-PEG4-MS | 130955-37-2 | ≥95.0% | 286.34 | C10H22O7S | 500 MG
m-PEG4-MS is a polyethylene glycol (PEG)-based linker used in small-molecule conjugation chemistry. It is suitable as a PROTAC linker for assembling proteolysis-targeting chimeras and as a cleavable linker in antibody-drug conjugate (ADC) synthesis, enabling conjugation and controlled release in bioconjugation workflows.
- Used in PROTAC synthesis
- Functions as a cleavable ADC linker
- PEG-based spacer for flexible linker design
- High purity suitable for research use
- Available as a 500 mg pack for preparative work
Broadpharm Bromoacetamido-PEG2-azide, 500mg
Bromoacetamido-PEG2-azide is a heterobifunctional PEG linker containing a reactive bromoacetamido and a terminal azide.The bromoacetamidogroup is a very reactive group for nucleophilic substitution. The azide group can react with alkyne, BCN, DBCO via Click Chemistry. Please contact us for GMP-grade inquiries.
Medchemexpress LLC Endo-BCN-PEG4-acid | 1881221-47-1 | 99.3% | 441.52 g/mol | C22H35NO8 | 5 MG
endo-BCN-PEG4-acid is a BCN-containing PEG4 linker used for bioconjugation and ADC synthesis. It enables strain-promoted alkyne-azide cycloaddition (SPAAC) click chemistry and provides a terminal carboxylic acid for covalent coupling. Supplied as a high-purity liquid for research applications.
- Cleavable PEG4 linker for bioconjugation.
- Facilitates strain-promoted alkyne-azide cycloaddition (SPAAC).
- Terminal carboxylic acid for amide coupling.
- High reported purity (99.3%).
- Liquid, colorless to light yellow; store frozen for long-term stability.
- For research use only; not for human therapeutic use.
eMolecules Bis-PEG1-acid | Broadpharm | 5961-83-1 | MFCD06208032 | 162.141 | C6H10O5 | 0.000 | OC(=O)CCOCCC(O)=O | 250mg | 279709653
Bis-PEG1-acid | Broadpharm | 5961-83-1 | MFCD06208032 | 162.141 | C6H10O5 | 0.000 | OC(=O)CCOCCC(O)=O | 250mg | 279709653
Medchemexpress LLC Mal-PEG2-Val-Cit-PAB-OH | 2055041-38-6 | 99.5% | 618.68 g/mol | C29H42N6O9 | 5 MG
Mal-PEG2-Val-Cit-PAB-OH is a cleavable antibody-drug conjugate (ADC) linker featuring a maleimide group, a PEG2 spacer, a valine-citrulline dipeptide cleavable linker, and a para-aminobenzyl (PAB) self-immolative spacer. It is supplied as a solid for research use and is intended for use in ADC and PROTAC synthesis.
- Cleavable Val-Cit dipeptide for enzyme-triggered payload release.
- Maleimide functional group enables thiol conjugation to antibodies or payloads.
- PEG2 spacer improves solubility and flexibility of the linker.
- PAB self-immolative spacer enables payload release after enzymatic cleavage.
- High purity (99.49% by COA) and molecular weight ~618.68 g/mol.
Medchemexpress LLC 3,6,9,12-tetraoxatridecan-1-amine | 85030-56-4 | MFCD11041099 | 98.8% | 207.27 | C9H21NO4 | 250 MG
m-PEG4-Amine is a polyethylene glycol (PEG) based bifunctional linker bearing a terminal primary amine. It is used as a short, flexible spacer in the synthesis of PROTACs and as a cleavable linker for antibody-drug conjugates, facilitating amine-based conjugation reactions.
- Provides a PEG4 spacer (~4 ethylene glycol units)
- Terminal primary amine for amide or carbamate conjugation
- High purity (98.8%) suitable for research use
- Molecular weight 207.27 g/mol
- Typically supplied as a solid; common pack size 250 MG
Medchemexpress LLC Biotin-PEG4-Amide-C6-Azide | 1006592-62-6 | 99.1% | C27H49N7O7S | 250 MG
Biotin-PEG4-Amide-C6-Azide is a PEG-based PROTAC linker used in the synthesis of PROTACs. It is also a click chemistry reagent containing an Azide group that can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with Alkyne groups, or strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. PROTACs utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins. This product is for research use only.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent with Azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc)
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
- Utilizes the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Broadpharm t-Boc-N-amido-PEG12-NHS 500mg
t-Boc-N-amido-PEG12-NHS ester is a PEG linker containing a Boc-protected amino group and an NHS ester group. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label the primary amines (-NH2) of proteins| amine-modified oligonucleotides| and other amine-containing molecules. The protected amine can be deprotected in acidic conditions. 500 MG
Medchemexpress LLC 4,7,10,13,19,22,25,28-Octaoxa-16-azahentriacontanedioic acid, 1,31-bis(1,1-dimethylethyl) ester | 2055041-41-1 | 98.0% | C30H59NO12 | 100 MG
NH-bis(PEG4-Boc) (HY-140258) is a chemical compound classified as a PROTAC linker. This compound has a chemical formula of C30H59NO12 and a CAS number of 2055041-41-1. It exhibits a purity of 98.0%.
Medchemexpress LLC 2,5-dioxopyrrolidin-1-yl 1-(4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl)-PEG4-SS-NHS ester | 95.0% | 737.84 | C31H43N7O10S2 | 10 MG
Methyltetrazine-PEG4-SS-NHS ester is a cleavable PEG4-based methyltetrazine-functionalized N-hydroxysuccinimide ester for bioconjugation and click-chemistry applications. It provides a tetrazine reactive handle for inverse electron-demand Diels-Alder labeling, and contains a disulfide cleavable spacer and PEG4 linker to improve solubility and enable reductive release.
- Purity 95.0% (NMR).
- Pink to red oil appearance.
- Molecular weight 737.84.
- Chemical formula C31H43N7O10S2.
- Contains a disulfide cleavable linker and a PEG4 spacer.
- Provides a tetrazine handle for IEDDA bioconjugation.
- Storage: pure form at -20°C (stable for 3 years); in solvent -80°C for 6 months, -20°C for 1 month.
- Tested by 1H NMR; for research use only.
![Medchemexpress LLC Propanoic acid, 3-[2-[2-[(4-formylbenzoyl)amino]ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester | 1807521-07-8 | 98.5% | 406.39 g·mol⁻1 | C19H22N2O8 | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000204110.png-250.jpg)
Medchemexpress LLC Propanoic acid, 3-[2-[2-[(4-formylbenzoyl)amino]ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester | 1807521-07-8 | 98.5% | 406.39 g·mol⁻1 | C19H22N2O8 | 100 MG
Ald-Ph-amido-PEG2-C2-NHS ester is a noncleavable two-unit polyethylene glycol (PEG) linker designed for antibody-agent conjugation (ADC) research. It features an NHS-activated ester for amine coupling and an aldehyde-phenyl functional handle for orthogonal conjugation chemistry.
- Provides a noncleavable 2-unit PEG spacer for conjugation
- NHS ester activated for efficient coupling to primary amines
- Aldehyde-phenyl functional group for orthogonal conjugation chemistry
- High purity suitable for research applications
- Available in multiple pack sizes and formats, including 100 MG
Medchemexpress LLC mPEG-N3 MW 2000 25mg
mPEG-N3 (MW 2000) can be used to modify proteins peptides and other materials The azide group can react with alkynes in aqueous solution catalyzed by copper It can also be easily reduced to an amine group PEGylation can increase solubility and stability and reduce the immunogenicity of peptides and proteins mPEG-N3 (MW 2000) can also inhibit the nonspecific binding of charged molecules to the modified surface[1]
Medchemexpress LLC Acid-PEG2-SS-PEG2-acid | 1807539-10-1 | 95.0% | 386.48 g/mol | C14H26O8S2 | 5 MG
Acid-PEG2-SS-PEG2-acid is a cleavable 4-unit polyethylene glycol (PEG) linker containing a central disulfide bond and terminal carboxylic acids, designed for use in antibody-drug conjugate (ADC) synthesis and bioconjugation. Supplied as a white to off-white solid for research use only.
- Cleavable disulfide bond enables intracellular release under reducing conditions.
- Terminal carboxyl groups allow amide coupling and conjugation chemistry.
- Four-unit PEG spacer improves solubility and reduces steric hindrance.
- High purity suitable for research applications.
- Solid, white to off-white appearance with recommended cold storage.