Protein Modification Reagents
eMolecules 581065-94-3 | Tos-peg5 t-butyl ester | Combi-Blocks | MFCD22574810 | 476.580 | C22H36O9S | 98.000 | Cc1ccc(cc1)S(=O)(=O)OCCOCCOCCOCCOCCC(=O)OC(C)(C)C | 1g | 267196212
Tos-peg5 t-butyl ester | Combi-Blocks | 581065-94-3 | MFCD22574810 | 476.580 | C22H36O9S | 98.000 | Cc1ccc(cc1)S(=O)(=O)OCCOCCOCCOCCOCCC(=O)OC(C)(C)C | 1g | 267196212
CCOCCOCCOCCNC(=O)OC1CCC\C=C\CC1)(OCC)OCC | 250mg | 550804547](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502183527.JPG-250.jpg)
eMolecules 2250217-32-2 | TCO-PEG3-triethoxysilane | Broadpharm576.803 | C27H52N2O9Si | 98.000 | CCO[Si](CCCNC(=O)CCOCCOCCOCCNC(=O)OC1CCC\C=C\CC1)(OCC)OCC | 250mg | 550804547
TCO-PEG3-triethoxysilane | Broadpharm | 2250217-32-2576.803 | C27H52N2O9Si | 98.000 | CCO[Si](CCCNC(=O)CCOCCOCCOCCNC(=O)OC1CCC\C=C\CC1)(OCC)OCC | 250mg | 550804547
eMolecules 88299-47-2 | C11-PEG4-alcohol | Broadpharm304.471 | C17H36O4 | 98.000 | CCCCCCCCCCCOCCOCCOCCO | 1g | 303671286
C11-PEG4-alcohol | Broadpharm | 88299-47-2304.471 | C17H36O4 | 98.000 | CCCCCCCCCCCOCCOCCOCCO | 1g | 303671286
eMolecules 2170987-96-7 | Amino-PEG24-t-butyl ester | Broadpharm | MFCD11041158 | 1202.474 | C55H111NO26 | 98.000 | CC(C)(C)OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN | 1g | 272384125
Amino-PEG24-t-butyl ester | Broadpharm | 2170987-96-7 | MFCD11041158 | 1202.474 | C55H111NO26 | 98.000 | CC(C)(C)OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN | 1g | 272384125
Cayman Chemical GefItInIb-based PROTAC 3 25mg
A PROTAC comprised of gefitinib linked to VHL ligand 1; induces degradation of EGFR containing the activating mutation L858R or an exon 19 deletion (DC50s = 22.3 and 11.7 nM, respectively) but does not induce degradation of wild-type EGFR at ≤10 μM in cell-based assays
Cayman Chemical ANTIBODY DBCO acId 50mg
A copper-free click chemistry reagent; has been used in the study of glycoprotein charge effects on the migration and invasion of 9-azido sialic acid-labeled cancer cells in vitro; has also been used in the synthesis of DBCO-modified RNase A to deliver RNase A into AAM-labeled cancer cells in vitro and in vivo to induce cytotoxicity and reduce tumor growth, respectively
Medchemexpress LLC Mpro inhibitor N3 hemihydrate | MFCD00274570 | 99.9% | 698.81 | C35H50N6O9 | 5 MG
Mpro inhibitor N3 hemihydrate is a small-molecule inhibitor of coronavirus main protease (Mpro) provided as a white to off-white solid hemihydrate for biochemical and antiviral research; product page lists purity, storage, and solubility information for experimental planning.
- Potent inhibitor of coronavirus main protease with reported cellular activity.
- High purity (99.86%).
- Supplied as a white to off-white solid hemihydrate.
- Stable when stored as powder at -20°C for up to 3 years.
- High solubility in DMSO (100 mg/mL) suitable for in vitro assays.
- Formulated for small-scale research applications.
Medchemexpress LLC t-Boc-N-amido-PEG5-Tos | 1404111-69-8 | MFCD34596623 | 96.0% | 491.60 | C22H37NO9S | 250 MG
t-Boc-N-amido-PEG5-Tos is a Boc-protected PEG5 linker bearing a tosyl leaving group. The hydrophilic PEG spacer improves solubility of conjugates, the tosyl enables efficient nucleophilic substitution, and the Boc group can be removed under mild acidic conditions to expose a primary amine. The reagent is intended for synthetic chemistry and bioconjugation applications.
- Hydrophilic PEG5 spacer improves aqueous solubility.
- Tosyl leaving group facilitates nucleophilic substitution.
- Boc-protected amine allows orthogonal deprotection strategies.
- Suitable for linker construction, bioconjugation, and PROTAC synthesis.
- Available in small research quantities for laboratory use.
eMolecules 880081-81-2 | Medchem Express | m-PEG8-O-alkyne | 50mg | 784543908 | HY-135932 | 422.515 | C20H38O9
Medchem Express | m-PEG8-O-alkyne | 50mg | 784543908 | HY-135932 | 880081-81-2 | 422.515 | C20H38O9
Medchemexpress LLC Mal-Ph-CONH-PEG4-NHS ester | 1263044-88-7 | 561.54 | 1 G
Mal-Ph-CONH-PEG4-NHS ester is a non-cleavable 4 unit PEG ADC linker designed for the synthesis of antibody-drug conjugates (ADCs).
- Non-cleavable linker
- 4 unit PEG
- Used in antibody-drug conjugate synthesis
Medchemexpress LLC Mal-PEG2-Val-Cit-PABA-PNP | 1345681-52-8 | 96.8% | 755.73 | C34H41N7O13 | 5 MG
Mal-PEG2-Val-Cit-PABA-PNP is a cleavable linker used in the synthesis of antibody-drug conjugates (ADCs). It contains a maleimide reactive group, a two-unit polyethylene glycol spacer, and a protease-sensitive Val-Cit-PABA peptide spacer that enables payload release in target cells.
- cleavable linker for ADC synthesis
- contains maleimide (Mal) reactive group
- two-unit PEG spacer (PEG2) provides solubility and flexibility
- val-cit-paba sequence is protease sensitive for intracellular release
- para-nitrophenyl (PNP) activating group for conjugation chemistry
- solid, white to off-white appearance; high purity
- available in multiple sizes and requires protection from light and storage under inert gas
Medchemexpress LLC N-Boc-PEG5-bromide | 1392499-32-9 | MFCD31536756 | 98.0% | 400.31 g/mol | C15H30BrNO6 | 500 MG
N-Boc-PEG5-bromide is a Boc-protected polyethylene glycol (PEG5) alkyl bromide linker used as a building block in medicinal chemistry for PROTAC and ADC linker synthesis. It provides an orthogonally protected amine and a terminal bromide for downstream coupling and substitution reactions. Supplied with high reported purity, it is intended for research use under appropriate laboratory conditions.
- Boc-protected amine for orthogonal deprotection.
- Five-unit PEG spacer provides flexibility and solubility.
- Terminal bromide enables nucleophilic substitution (SN2) chemistry.
- Reported purity approximately 98.0%.
- Suitable for assembly of PROTAC and ADC linkers.
- Recommended cold storage to preserve stability.
Medchemexpress LLC (S,R,S)-AHPC-PEG1-N3 | 2101200-09-1 | 98.8% | 557.67 g/mol | C26H35N7O5S | 50 MG
(S,R,S)-AHPC-PEG1-N3 is a VHL E3 ligase ligand-linker conjugate that incorporates an (S,R,S)-AHPC VHL ligand and a single-unit polyethylene glycol (PEG1) linker terminated with an azide. It is designed as a building block for PROTAC assembly and for click-chemistry conjugations (CuAAC), enabling attachment of functional moieties to VHL ligands.
- Contains an azide functional group for copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- Single-unit PEG linker provides improved solubility and controlled spacing between ligands.
- High purity (>98.7%) and molecular weight 557.67 g/mol for consistent characterization.
- Soluble in DMSO (100 mg/mL); insoluble in water (<0.1 mg/mL).
- Stable as a powder when stored at -20°C (up to 3 years) or 4°C (up to 2 years).
Medchemexpress LLC Dspe-peg-biotin | 98.4% | 3400 Da | 25 MG
Biotinylated DSPE-PEG is an amphiphilic PEG-lipid conjugate (average molecular weight 3,400 Da) used to introduce biotin functionality into lipid assemblies. The DSPE lipid anchors the conjugate in bilayers while the PEG spacer presents biotin for high-affinity interactions with streptavidin/avidin. Supplied as a powder for research use, it is commonly applied in targeted delivery, surface functionalization, and assay development.
- Amphiphilic structure enables incorporation into liposomes and micelles.
- Biotin end-group for high-affinity binding to streptavidin/avidin.
- Average molecular weight 3.4 kDa for the PEG spacer.
- High reported purity (~98.4%).
- Available in small powder pack sizes for research use (for example, 25 mg).
- Recommended storage as powder at -20°C to maintain stability.
Medchemexpress LLC DOTA-PEG5-amine | 98.0% | 666.76 | 50 MG
DOTA-PEG5-amine is a PEG-based PROTAC linker designed for the synthesis of PROTACs. These molecules feature two ligands connected by a linker, one targeting an E3 ubiquitin ligase and the other a target protein. PROTACs utilize the intracellular ubiquitin-proteasome system to selectively degrade specific target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Contains two different ligands connected by a linker
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- For research use only