Protein Modification Reagents
eMolecules 1343476-41-4 | Acid-PEG5-NHS ester | Broadpharm | MFCD27952888 | 435.426 | C18H29NO11 | 98.000 | OC(=O)CCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O | 500mg | 249969232
Acid-PEG5-NHS ester | Broadpharm | 1343476-41-4 | MFCD27952888 | 435.426 | C18H29NO11 | 98.000 | OC(=O)CCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O | 500mg | 249969232
Medchemexpress LLC m-PEG6-CH2CH2COOH | 874208-91-0 | MFCD20926396 | ≥95.0% | 368.42 g·mol⁻¹ | C16H32O9 | 250 MG
m-PEG6-CH2CH2COOH is a polyethylene glycol (PEG)-based linker intended for use as a chemical building block in the synthesis of PROTACs and other bioconjugates. It is provided as a research reagent with high purity and defined molecular properties suitable for medicinal chemistry and linker optimization workflows.
- PEG-based linker suitable for PROTAC and bioconjugation applications.
- High purity (≥95%) supports reliable reaction performance.
- Defined molecular weight (368.42 g·mol⁻¹) for stoichiometric calculations.
- Supplied in small pack sizes convenient for medicinal chemistry research.
- Available CAS identifier for unambiguous chemical reference.
Medchemexpress LLC Azide-PEG4-VC-PAB-doxorubicin | 99.6% | 1222.25 g/mol | C57H75N9O21 | 5 MG
Azide-PEG4-VC-PAB-doxorubicin is a drug-linker conjugate that links the cytotoxic agent doxorubicin to an azide-PEG4-VC-PAB cleavable linker, intended for use in antibody-drug conjugate (ADC) construction and click-chemistry conjugation (CuAAC and SPAAC).
- Contains an azide functional group for click conjugation.
- Compatible with copper-catalyzed azide-alkyne cycloaddition and strain-promoted alkyne-azide cycloaddition reactions.
- Features a cleavable valine-citrulline-p-aminobenzyl (VC-PAB) linker for intracellular release.
- Supplied as an orange to red solid for convenient handling and storage.
- Purity 99.6% and molecular weight 1222.25 g/mol.
- Available in small-mass pack sizes suitable for research-scale ADC synthesis.
Medchemexpress LLC Mal-PEG4-VA-PBD | 1342820-68-1 | 1294.40 g/mol | C68H79N9O17 | 1 MG
Mal-PEG4-VA-PBD is an agent-linker conjugate for antibody-drug conjugate (ADC) development that incorporates a pyrrolobenzodiazepine (PBD) cytotoxic warhead linked via a maleimide-PEG4-valine-alanine (Mal-PEG4-VA) cleavable linker. It is intended for bioconjugation to antibodies through thiol-reactive maleimide chemistry.
- Agent-linker conjugate for ADC development.
- Pyrrolobenzodiazepine (PBD) cytotoxic payload.
- Maleimide-PEG4-valine-alanine cleavable linker for thiol conjugation.
- Suitable for bioconjugation to antibodies and other thiol-containing biomolecules.
- Supplied in milligram quantities for research use.
Medchemexpress LLC Mal-amido-PEG5-C2-NHS ester | 1315355-92-0 | ≥98.0% | 557.55 g·mol⁻1 | C24H35N3O12 | 100 MG
Mal-amido-PEG5-C2-NHS ester is a noncleavable linker reagent combining a maleimide and an N-hydroxysuccinimide (NHS) ester for thiol- and amine-directed bioconjugation. It is intended for labeling primary amines and for constructing stable linkages in antibody-drug conjugates, protein, and oligonucleotide conjugations.
- Contains maleimide for thiol-selective conjugation
- Contains NHS ester reactive toward primary amines
- High purity (≥98.0%) suitable for research use
- Molecular weight ~557.55 and formula C24H35N3O12
- Available in a 100 mg package for lab-scale synthesis and labeling workflows
Medchemexpress LLC Pomalidomide-PEG6-C2-COOH | 2225148-49-0 | 99.0% | C28H39N3O12 | 25 MG
Pomalidomide-PEG6-C2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide-based cereblon ligand and a 6-unit PEG linker used in PROTAC technology. It has a molecular weight of 609.62 and appears as a viscous liquid, light yellow to yellow in color. This product is for research use only.
- E3 ligase ligand-linker conjugate
- Incorporates Pomalidomide based cereblon ligand
- Contains a 6-unit PEG linker
- Used in PROTAC technology
Medchemexpress LLC Tco-peg4-vc-pab-mmae | 2758671-45-1 | 99.3% | 1522.91 | C78H127N11O19 | 1 MG
TCO-PEG4-VC-PAB-MMAE is a drug-linker conjugate used in antibody-drug conjugate (ADC) research and click-chemistry applications; it couples a trans-cyclooctene (TCO) reactive handle to a PEG4-spaced valine-citrulline-para-aminobenzyl (Val-Cit-PAB) cleavable linker and the cytotoxic payload MMAE.
- High purity (99.3%).
- Molecular weight 1522.91 g/mol.
- Chemical formula C78H127N11O19.
- CAS number 2758671-45-1.
- Suitable for iEDDA click chemistry with tetrazine reagents.
- Intended for ADC synthesis and conjugation research.
- Store at -20°C and protect from light; in solvent store at -80°C up to 6 months or -20°C up to 1 month.
- Available in small research pack sizes (e.g., 1 MG).
eMolecules Benzyl-PEG4-CH2CO2tBu | 1443467-88-6 | MFCD28122956 | 1g
Broadpharm | Benzyl-PEG4-CH2CO2tBu | 1g | 254745474 | BP-22262 | 97.000 | 1443467-88-6 | MFCD28122956 | 354.443 | C19H30O6
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eMolecules Building Block Tool
STA PHARMACEUTICAL US LLC Fmoc-N-PEG7-acid | 25 g | CAS 1863885-74-8 | MDL MFCD26142985
Fmoc-N-PEG7-acid is a Amino Acid reagent (Subcategory: PEG AA) sold by WuXi TIDES. Offered in 25 g. Store at 4 °C. SDS available for reference.
Specifications
- CAS: 1863885-74-8
- MDL: MFCD26142985
- InChIKey: QTWMNLIXRWCJSM-UHFFFAOYSA-N
- Molecular Weight: 619.708
- Molecular Formula: C32H45NO11
- Purity: ≥95%
- Container Type: 125 mL HDPE
- Pack Size: 25 g
- Net Weight: 25 g
- Gross Weight: 54.3 g
- Commodity Code: 29242970
- Country Of Origin: China
- IUPAC: 1-(9H-fluoren-9-yl)-3-oxo-2,7,10,13,16,19,22,25-octaoxa-4-azaoctacosan-28-oic acid
- SMILES: O=C(CCOCCOCCOCCOCCOCCOCCOCCNC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)O
eMolecules S-acetyl-PEG3-alcohol | 153870-20-3 | MFCD22574787 | 1g
Broadpharm | S-acetyl-PEG3-alcohol | 1g | 137364442 | BP-20945 | 98.000 | 153870-20-3 | MFCD22574787 | 208.270 | C8H16O4S
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Medchemexpress LLC Tos-PEG4-t-butyl ester | 217817-01-1 | 100 MG
Tos-PEG4-t-butyl ester is a PROTAC linker characterized by its PEG composition. It is utilized in the synthesis of various PROTACs, including BI-3663. BI-3663 is a highly selective PTK2/FAK PROTAC that employs cereblon ligands to facilitate E3 ligase hijacking for PTK2 degradation, demonstrating an IC50 of 18 nM for PTK2 inhibition.
- PROTAC linker
- Used in the synthesis of PROTACs
- Specific application in creating highly selective PTK2/FAK PROTACs
- Inhibits PTK2 with an IC50 of 18 nM when used in PROTACs
![Medchemexpress LLC Ethanol, 2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy] tosylate | 236754-49-7 | 99.3% | 417.48 g/mol | C17H27N3O7S | 500 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000203783.png-250.jpg)
Medchemexpress LLC Ethanol, 2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy] tosylate | 236754-49-7 | 99.3% | 417.48 g/mol | C17H27N3O7S | 500 MG
Azide-PEG5-Tos is a cleavable PEG-based linker bearing an azide functional group and a tosylate leaving group. It is used as a click-chemistry handle and linker in the synthesis of antibody-drug conjugates and other bioconjugation applications. The reagent is supplied as a solid and is typically dissolved in DMSO for reactions.
- Cleavable 5-unit polyethylene glycol spacer
- Contains an azide functional group for copper-catalyzed azide-alkyne cycloaddition
- Contains a tosylate leaving group for downstream modification
- High purity suitable for synthetic chemistry applications
- Stable under cold storage when handled per supplier recommendations
Cell Signaling Technology PTMScanR Malonyl-Lysine Mal-K Kit 1 Kit
PTMScanR Malonyl-Lysine Mal-K Kit 1 Kit
Medchemexpress LLC DSPE-biotin | 133695-76-8 | MFCD34561787 | 97.5% | 974.36 | C51H96N3O10PS | 10 MG
DSPE-Biotin is a biotinylated phospholipid used to introduce biotin functionality into liposomes, lipid bilayers, and other lipid-based formulations for biochemical research and bioconjugation. It facilitates specific capture, labeling, and immobilization through high-affinity streptavidin/avidin interactions.
- Provides biotin functionality for liposomes and lipid bilayers.
- Enables high-affinity binding to streptavidin and avidin.
- Suitable for liposome formulation and surface immobilization applications.
- Soluble in DMSO; ultrasonic warming improves solubility.
- High purity for research use; handle and store protected from light.
- Stable when stored at -20°C for long-term storage.
