Protein Modification Reagents
STEMCELL Technologies Collagenase Type I, Size: 5 g
Collagenase is a protease consisting of a single polypeptide chain approximately 1000 amino acid residues in length. Collagenase is capable of digesting native collagen fibrils commonly found in connective tissues and therefore is frequently used for tissue dissociation. Collagenase Type I contains the activity of several proteases including collagenase caseinase clostripain and trypsin. Collagenase Type I has been used for the digestion of human tissues such as intestine (Barthel et al.) mammary glands (Huss Kratz) and prostate (Le et al.) as well as specific cell types such as endothelial cells (Ganguly et al.) and dorsal root ganglion cells (Dib-Hajj et al.).
STEMCELL Technologies Collagenase Type III, Size: 5 g
Collagenase is a protease consisting of a single polypeptide chain approximately 1000 amino acid residues in length. Collagenase is capable of digesting native collagen fibrils commonly found in connective tissues and therefore is frequently used for tissue dissociation. Collagenase preparations contain the activity of several proteases including collagenase caseinase clostripain and trypsin (Kessler Yaron). Collagenase Type III contains low levels of proteolytic activity especially for caseinase clostripain and trypsin. Collagenase Type III has been used for the digestion of mammary glands (Rønnov-Jessen et al.) colon cancer stem cells (Prince et al.) and breast epithelial tumor cells (Chan et al.).
Medchemexpress LLC Puromycin-bis(PEG2-amide)-Biotin | 2379889-82-2 | 98.8% | 1046.20 | 5 MG
Puromycin-bis(PEG2-amide)-Biotin is a binding molecule that targets ribosome-RNA complexes within single cells. It is specifically designed for use in single-cell translatome sequencing applications.
- Binds to ribosome-RNA complexes within single cells.
- Used for single-cell translatome sequencing.
- Can penetrate single cells (mouse oocytes, zebrafish embryo cells, HeLa cells) at concentrations of 50-1000 μM for 30 seconds to 30 minutes.
Medchemexpress LLC Mal-PEG8-Val-Cit-PAB-MMAE | 3058970-85-4 | 97.1% | 1626.97 | 1 MG
Mal-PEG8-Val-Cit-PAB-MMAE is an agent-linker conjugate designed for Antibody-Drug Conjugates (ADCs). This compound incorporates a cleavable ADC linker and the potent tubulin inhibitor MMAE. ADCs consist of an antibody to which an ADC cytotoxin is attached via an ADC linker. It is for research use only and has not been fully validated for medical applications.
- Contains a cleavable ADC linker.
- Includes MMAE, a potent tubulin inhibitor.
- Suitable for Antibody-Drug Conjugate (ADC) research.
eMolecules MAL-PEG2-ACID | AstaTech | 1374666-32-6 | MFCD23726620 | 257.242 | C11H15NO6 | 95.000 | OC(=O)CCOCCOCCN1C(=O)C=CC1=O | 0.25g | 464144612
MAL-PEG2-ACID | AstaTech | 1374666-32-6 | MFCD23726620 | 257.242 | C11H15NO6 | 95.000 | OC(=O)CCOCCOCCN1C(=O)C=CC1=O | 0.25g | 464144612
Medchemexpress LLC H-151 Alkyne | 2244892-03-1 | 95.1% | 275.30 | 25 MG
H-151 Alkyne (Compound H-151-AL) is a selective STING (Stimulator of interferon genes) inhibitor. It is promising for research of autoimmune diseases such as systemic lupus erythematosus, scleroderma, and autoinflammatory diseases.
- Selective STING (Stimulator of interferon genes) inhibitor.
- Promising for research of autoimmune diseases such as systemic lupus erythematosus, scleroderma, and autoinflammatory diseases.
Medchemexpress LLC VH285-PEG4-C4-Cl (HaloPROTAC 3) | 1799506-07-2 | ≥98.0% | 799.42 | 10 MG
VH285-PEG4-C4-Cl (HaloPROTAC 3) is a conjugate of ligands for E3 and a 16-atom-length linker, with a Halogen group as the connector of the linker. It incorporates the VH285 based VHL ligand and an alkyl/ether-based linker. It is a highly potent and efficacious degrader of GFP-HaloTag7 with a DC50 of 19 nM, and can induce 90% degradation of GFP-Halotag at 625 nM. It binds to VHL with an IC50 of 0.54 μM.
- Conjugate of ligands for E3 and a 16-atom-length linker.
- Connector of linker is a Halogen group.
- Incorporates VHL ligand and an alkyl/ether-based linker.
- Highly potent and efficacious degrader of GFP-HaloTag7 (DC50 of 19 nM).
- Able to induce 90% degradation of GFP-Halotag at 625 nM.
- Binds to VHL with an IC50 of 0.54 μM.
Cayman Chemical TCEP-botn 1mg
An affinity probe for protein lysine crotonylation; addition of the TCEP moiety to crotonylated lysine residues results in adduct formation that allows for detection or immobilization of crotonylated proteins through interaction with the biotin ligand; has been used in the detection and isolation of crotonylated histones in HEK293 cells