Protein Modification Reagents
Cayman Chemical VH 032 LInker 1 100mg
A PROTAC precursor; has been used in the synthesis of PROTACs targeting TEAD in cancer cells
eMolecules 2182602-22-6 | Mal-amido-PEG9-amine TFA salt | Broadpharm607.698 | C27H49N3O12 | 98.000 | NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCN1C(=O)C=CC1=O | 500mg | 368397735
Mal-amido-PEG9-amine TFA salt | Broadpharm | 2182602-22-6607.698 | C27H49N3O12 | 98.000 | NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCN1C(=O)C=CC1=O | 500mg | 368397735
Grainger Closed End Peg Rack 19.88 L Blue PK6
The Carlisle Closed End Peg Rack is a 19-7/8" long metal peg rack with closed ends. It has 20 evenly spaced pegs that are 1/2" in diameter and protrude 1-1/4" from the rack. The rack is made from steel with a durable powder coat finish and can hold up to 50 lbs per linear foot. This versatile rack can be used for retail displays, workshops, garages, basements, and more to hang tools, hardware, accessories, apparel and other items with holes or hooks. It comes with mounting hardware for easy installation on walls or pegboards. The closed ends prevent items from sliding off the ends of the rack.
Medchemexpress LLC Mal-PEG4-PFP ester | 1415800-42-8 | 95.4% | 511.39 g·mol-1 | C21H22F5NO8 | 1 G
Mal-PEG4-PFP ester is a noncleavable ADC linker that incorporates a maleimide reactive group, a four-unit polyethylene glycol (PEG4) spacer, and a pentafluorophenyl (PFP) activated ester. It is supplied for research use to enable conjugation of payloads to thiol- or amine-containing biomolecules.
- Noncleavable ADC linker with a maleimide reactive group.
- Four-unit PEG spacer for increased solubility and flexibility.
- PFP ester activated for efficient coupling to amines.
- Molecular weight 511.39 g·mol-1.
- Chemical formula C21H22F5NO8.
- Purity 95.4% (as supplied).
- Storage: pure form -20°C for 3 years, 4°C for 2 years; in solvent -80°C for 6 months, -20°C for 1 month.
- Intended for research use only; not for human or clinical use.
Medchemexpress LLC Pomalidomide-PEG4-azide | 2271036-47-4 | 99.85% | C23H30N6O8 | 50 MG
Pomalidomide-PEG4-azide is a synthesized E3 ligase ligand-linker conjugate designed for PROTAC technology. It incorporates a Pomalidomide-based cereblon ligand and functions as a click chemistry reagent. This compound contains an Azide group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates cereblon ligand
- Used in PROTAC technology
- Click chemistry reagent with Azide group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Facilitates strain-promoted alkyne-azide cycloaddition (SPAAC)
- Targets Cereblon
Medchemexpress LLC TAMRA-Azide-PEG-biotin | 1797415-74-7 | 99.0% | C57H79N11O14S | 1 MG
TAMRA-Azide-PEG-biotin is a dye derivative of TAMRA. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Dye derivative of TAMRA.
- Contains an azide group.
- Undergoes copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkyne groups.
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Solid, purple to purplish red appearance.
![Medchemexpress LLC Acetamide 2-(2-aminoethoxy)-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]HCl | 2380273-67-4 | 97.1% | 410.81 g/mol | C17H19ClN4O6 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000221842.png-250.jpg)
Medchemexpress LLC Acetamide 2-(2-aminoethoxy)-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]HCl | 2380273-67-4 | 97.1% | 410.81 g/mol | C17H19ClN4O6 | 5 MG
Pomalidomide-PEG1-NH2 hydrochloride is a pomalidomide-based E3 ligase ligand-linker conjugate (hydrochloride salt) featuring a short PEG linker terminated in a primary amine. It is designed for use in targeted protein degradation chemistry as a cereblon-recruiting ligand and for covalent coupling to target ligands via the terminal amine.
- Primary amine-terminated PEG1 linker for conjugation to carboxyl groups.
- E3 ligase (cereblon) recruiter based on a pomalidomide scaffold.
- Supplied as a hydrochloride salt for improved stability and handling.
- High purity (~97%) suitable for research and medicinal chemistry.
- Available in multiple small-mass package sizes for synthesis work.
eMolecules DBCO-PEG6-NHS ester | Broadpharm |737.803 | C38H47N3O12 | 95.000 | O=C(CCC(=O)N1Cc2ccccc2C#Cc2ccccc12)NCCOCCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O | 25mg | 698442844
DBCO-PEG6-NHS ester | Broadpharm |737.803 | C38H47N3O12 | 95.000 | O=C(CCC(=O)N1Cc2ccccc2C#Cc2ccccc12)NCCOCCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O | 25mg | 698442844
Medchemexpress LLC DSPE PEG thiol | 25322-68-3 | 99.4% | 2000 (average) | 100 MG
DSPE-PEG-SH (MW 2000) is a thiol-terminated pegylated phospholipid used to introduce reactive thiol groups into lipid assemblies. The thiol group readily forms stable thioether linkages with maleimide and other electrophiles, enabling surface functionalization of liposomes and lipid nanoparticles for targeted delivery and conjugation of ligands such as peptides or antibodies.
- Thiol terminus enables covalent conjugation with maleimide groups.
- Incorporates into liposomes and lipid nanoparticles for surface functionalization.
- Amphipathic structure supports bilayer formation in aqueous systems.
- High purity (≈99.4%) suitable for research applications.
- Soluble in water and DMSO with warming and sonication.
Medchemexpress LLC m-PEG-DMG | 1019000-64-6 | 98.0% | 2000 Da (average) | (C2H4O)nC36H73NO5 | 100 MG
m-PEG-DMG (MW 2000) is a methoxy-terminated polyethylene glycol conjugated to dimyristoylglycerol. Supplied as a solid with an average molecular weight of about 2000 Da, it is formulated for preparation of PEGylated liposomes and lipid nanoparticles used in drug delivery research and related in vitro studies.
- High purity (98.0%).
- Average molecular weight ~2000 Da.
- White to off-white solid form.
- Suitable for liposome and lipid nanoparticle formulation.
- Provides steric stabilization and reduced protein opsonization.
- Available in small laboratory pack sizes (e.g., 5-100 mg).
- Documentation available: data sheet, COA, and SDS.
Medchemexpress LLC DBCO-PEG2-NHS ester | 2585653-12-7 | MFCD34551891 | ≥98.0% | 561.58 | C30H31N3O8 | 10 MG
DBCO-PEG2-NHS ester is an amine-reactive, click-chemistry reagent that installs a dibenzocyclooctyne (DBCO) handle via an N-hydroxysuccinimide (NHS) ester and a short PEG2 spacer. It is designed for efficient bioconjugation and copper-free strain-promoted azide-alkyne cycloaddition in research applications.
- Amine-reactive NHS ester enables rapid and selective coupling to primary amines.
- DBCO functionality supports copper-free strain-promoted click chemistry.
- P EG2 spacer improves solubility and reduces steric hindrance for conjugation.
- High purity (≥98.0%) suitable for sensitive research workflows.
- Stable as powder at -20°C for long-term storage.
eMolecules 2141976-28-3 | Methyltetrazine-PEG3-amine, TFA salt | Broadpharm404.471 | C19H28N6O4 | 0.000 | Cc1nnc(nn1)-c1ccc(CNC(=O)CCOCCOCCOCCN)cc1 | 50mg | 649282308
Methyltetrazine-PEG3-amine, TFA salt | Broadpharm | 2141976-28-3404.471 | C19H28N6O4 | 0.000 | Cc1nnc(nn1)-c1ccc(CNC(=O)CCOCCOCCOCCN)cc1 | 50mg | 649282308
Medchemexpress LLC Folic acid-PEG5-Mal | 00-00-0 | 99.5% | C35H45N9O12 | 10MG
FA-PEG5-Mal is a polyethylene glycol (PEG)-based linker developed for constructing proteolysis-targeting chimeras (PROTACs). It combines a folic acid-derived ligand with a PEG5 spacer and a maleimide functional group to enable selective conjugation to thiol-containing partners. Supplied as a solid for laboratory research use, it offers high purity and convenient solubility in DMSO for bioconjugation and linker assembly workflows.
- Provides a folic acid ligand for target engagement
- Contains a PEG5 spacer to give flexible linker length
- Includes a maleimide functional handle for thiol coupling
- Supplied as a solid suitable for laboratory research use
- High purity for reliable synthetic results
- Soluble in DMSO (100 mg/mL) with ultrasonic assistance recommended
Medchemexpress LLC Pomalidomide-5'-PEG5-C2-COOH | 2412056-50-7 | 565.57 | 100 MG
Pomalidomide-5'-PEG5-C2-COOH is an active compound and drug derivative used for various biochemical research purposes. This compound requires specific storage conditions to maintain its stability.
- Active compound and drug derivative
- Store at -20°C, protected from light, and under nitrogen
- In solvent, store at -80°C for 6 months or -20°C for 1 month, protected from light and under nitrogen
- Soluble in DMSO at 100 mg/mL (176.81 mM; requires ultrasonic)
- Molecular formula: C₂₆H₃₅N₃O₁₁
Medchemexpress LLC DBCO-PEG6-NHS ester | 96.0% | 737.79 | 5 MG
DBCO-PEG6-NHS ester is a click chemistry PEG reagent that contains an NHS ester. This NHS ester specifically reacts with primary amines, such as the side chains of lysine residues or aminosilane-coated surfaces, forming covalent bonds efficiently under neutral or slightly alkaline conditions. Additionally, DBCO-PEG6-NHS ester includes a DBCO group, which can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
- Reacts specifically with primary amines.
- Contains a DBCO group for SPAAC with Azide groups.