Protein Modification Reagents
eMolecules 1644644-96-1 | Medchem Express | Methyltetrazine-Ph-NHS ester | 50mg | 736630605 | HY-130283 | MFCD28334557 | 327.3 | C15H13N5O4
Medchem Express | Desmorpholinyl Navitoclax-NH-Me | 5mg | 536984097 | HY-131232 | 2365172-82-1 | 918.550 | C44H51ClF3N5O5S3
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Medchemexpress LLC Azido-PEG4-Amido-Tris | 1398044-55-7 | 96.4% | C15H30N4O8 | 100 MG
Azido-PEG4-Amido-Tris is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an Azide group that can participate in copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules possessing Alkyne groups. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. PROTACs involve two distinct ligands connected by a linker, one for an E3 ubiquitin ligase and the other for the target protein, enabling the selective degradation of target proteins via the intracellular ubiquitin-proteasome system.
- PEG-based PROTAC linker
- Click chemistry reagent
- Contains an Azide group for CuAAc reaction
- Can undergo SPAAC reactions
- Used in the synthesis of PROTACs
Medchemexpress LLC Methyltetrazine-PEG4-acid | 1802907-91-0 | 99.8% | C20H28N4O7 | 25 MG
Methyltetrazine-PEG4-acid is a solid laboratory chemical primarily used for the manufacture of substances. It has a molecular weight of 436.46 and typically appears as a purple to purplish-red solid.
- Purity: 99.8% (HPLC)
- Molecular formula: C20H28N4O7
- Stable under recommended storage conditions
- Boiling point/range: 647.6±65.0 °C at 760 mmHg
- Relative density: 1.236 g/cm³
- Recommended storage:
- Powder: -20°C for 3 years; 4°C for 2 years
- In solvent: -80°C for 6 months; -20°C for 1 month
Medchemexpress LLC (S,R,S)-AHPC-PEG2-acid | 2172820-09-4 | 98.9% | C30H42N4O8S | 25 MG
(S,R,S)-AHPC-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
- PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.
- PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Medchemexpress LLC Azide-PEG4-Tos | 168640-82-2 | 99.6% | C15H23N3O6S | 500 MG
Azide-PEG4-Tos is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. This compound functions as a click chemistry reagent, featuring an Azide group. It can engage in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules containing Alkyne groups, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups.
- PEG-based PROTAC linker.
- Click chemistry reagent.
- Contains an azide group, enabling CuAAc reactions with alkyne groups.
- Can participate in SPAAC reactions with DBCO or BCN groups.
![eMolecules 2055105-33-2 | Biotin-PEG12-TFP ester | Broadpharm | MFCD28385459 | 992.080 | C43H69F4N3O16S | 95.000 | Fc1cc(F)c(F)c(OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCCC[C@@H]2SC[C@@H]3NC(=O)N[C@H]23)c1F | 500mg | 272383789](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502203186.JPG-250.jpg)
eMolecules 2055105-33-2 | Biotin-PEG12-TFP ester | Broadpharm | MFCD28385459 | 992.080 | C43H69F4N3O16S | 95.000 | Fc1cc(F)c(F)c(OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCCC[C@@H]2SC[C@@H]3NC(=O)N[C@H]23)c1F | 500mg | 272383789
Biotin-PEG12-TFP ester | Broadpharm | 2055105-33-2 | MFCD28385459 | 992.080 | C43H69F4N3O16S | 95.000 | Fc1cc(F)c(F)c(OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCCC[C@@H]2SC[C@@H]3NC(=O)N[C@H]23)c1F | 500mg | 272383789
Cayman Chemical XnthIn amIn congenr 25mg
A non-selective adenosine receptor antagonist (Kbs = 83, 25, and 15 nM for rat PC 12 cells, human platelets, and rat fat cells, respectively); reduces NECA-stimulated adenylate cyclase activity in human platelets (EC50s = 1 and 0.31 μM in the presence and absence of XAC, respectively); reverses R-PIA-induced inhibition of isoproterenol-stimulated adenylate cyclase activity in rat fat cell membranes (IC50s = 146 and 26 nM in the presence and absence of XAC, respectively); reverses 2-CADO-, R-PIA-, and NECA-induced reductions in heart rate and blood pressure in rats (0.1-1.0 mg/kg); induces convulsions in mice (39.8 mg/kg)
Medchemexpress LLC Thiol-PEG2-t-butyl ester | 1398044-50-2 | MFCD22574781 | 96.0% | 250.35 g·mol-1 | C11H22O4S | 5 MG
Thiol-PEG2-t-butyl ester is a short polyethylene glycol (PEG2) linker bearing a tert-butyl-protected thiol, designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). It provides a hydrophilic spacer and a masked thiol functionality for selective deprotection and conjugation in medicinal chemistry workflows.
- Provides a short PEG2 spacer to improve solubility and flexibility.
- Contains a tert-butyl-protected thiol for masked thiol chemistry.
- Suitable for incorporation into bifunctional PROTAC molecules.
- Available in research-scale pack sizes for synthetic work.
- Molecular weight ~250.35 g·mol-1 and formula C11H22O4S.
Medchemexpress LLC Amino-PEG4-Val-Cit-PAB-MMAE | 1492056-71-9 | 99.9% | 1370.71 | C69H115N11O17 | 1 MG
Amino-PEG4-Val-Cit-PAB-MMAE is a cleavable 4-unit PEG antibody-drug conjugate (ADC) linker used to attach cytotoxic payloads such as MMAE to antibodies during ADC synthesis. It contains a Val-Cit dipeptide cleavable spacer and a para-aminobenzyl (PAB) self-immolative spacer with a PEG4 solubilizing linker, providing controlled payload release in target cells.
- Cleavable Val-Cit peptide spacer enabling enzyme-triggered release
- PAB self-immolative spacer for efficient payload release
- PEG4 linker improves solubility and spacer length
- High reported purity (approximately 99.9%)
- Soluble in DMSO and compatible with common in vivo formulations
eMolecules 2353410-14-5 | t-Boc-Aminooxy-PEG8-alcohol | Broadpharm485.571 | C21H43NO11 | 98.000 | CC(C)(C)OC(=O)NOCCOCCOCCOCCOCCOCCOCCOCCO | 500mg | 550804524
t-Boc-Aminooxy-PEG8-alcohol | Broadpharm | 2353410-14-5485.571 | C21H43NO11 | 98.000 | CC(C)(C)OC(=O)NOCCOCCOCCOCCOCCOCCOCCOCCO | 500mg | 550804524
Medchemexpress LLC 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-PEG-thiol | >95.0% | 25 MG
DSPE-PEG-SH (average MW 1,000 Da) is a thiol-terminated PEGylated phospholipid combining a DSPE lipid anchor with a polyethylene glycol spacer that ends in a reactive sulfhydryl. Supplied as a solid, it is used to introduce surface-accessible thiol groups into liposomes, lipid nanoparticles, and other lipid assemblies for bioconjugation and targeted delivery applications.
- Provides a lipid anchor for stable incorporation into bilayers.
- Contains a terminal thiol (-SH) for conjugation to thiol-reactive reagents.
- Average molecular weight ~1,000 Da for the PEG spacer.
- Facilitates surface functionalization of nanoparticles and liposomes.
- Typically supplied as a powder with high purity (≥95%).
- Useful for preparing targeted delivery systems and bioconjugates.
Cayman Chemical Aceclofenac methyl ester 100mg
A potential impurity in commercial preparations of aceclofenac; has been used as a precursor in the synthesis of aceclofenac
Chemscene ChemScene | Biotin-PEG4-hydrazide | 100MG | CS-0114565 | 0.97 | 756525-97-0| MFCD09952658 | 505.63
ChemScene | Biotin-PEG4-hydrazide | 100MG | CS-0114565 | 0.97 | 756525-97-0| MFCD09952658 | 505.63
Medchemexpress LLC Mal-amido-PEG1-C2-NHS ester | 1260092-50-9 | 99.7% | 381.34 g/mol | C16H19N3O8 | 10 MG
Mal-amido-PEG1-C2-NHS ester is a noncleavable ADC linker that contains a maleimide group and an N-hydroxysuccinimide (NHS) ester, enabling conjugation to thiols and primary amines for antibody-drug conjugate construction and bioconjugation.
- Contains maleimide and NHS ester functional groups for thiol and amine coupling.
- Molecular weight approximately 381.34 g/mol.
- Chemical formula C16H19N3O8; white to off-white solid.
- High purity (listed as 99.69%) suitable for research applications.
- Soluble in DMSO (100 mg/mL) with recommended in vivo formulation examples.
- Store protected from light, under inert gas; stability varies by storage temperature.
Medchemexpress LLC Dbco-PEG4-VC-PAB-DMEA-PNU-159682 | 2259318-56-2 | 1695.81 g/mol | C86H106N10O26 | 1 MG
DBCO-PEG4-VC-PAB-DMEA-PNU-159682 is an ADC linker-drug conjugate designed for antibody-drug conjugate synthesis and click-chemistry conjugation. It contains a DBCO group for strain-promoted alkyne-azide cycloaddition, a four-unit PEG spacer for solubility, a valine-citrulline cleavable dipeptide with a para-aminobenzyl self-immolative spacer, and a DMEA-modified PNU-159682 payload.
- Facilitates SPAAC (strain-promoted alkyne-azide cycloaddition) for bioorthogonal conjugation.
- PEG4 spacer improves solubility and reduces steric hindrance.
- Val-Cit-PAB linker enables protease-cleavable payload release.
- Includes a potent PNU-159682-based payload for ADC research applications.
- Supplied in small research quantities suitable for conjugation studies.