Since 1978, List Labs products are unsurpassed in quality, consistency, and reliability for the success of your research and development projects!  Clostridium difficile is the causative agent of antibiotic-associated diarrhea and pseudomembranous colitis.  It produces two major exotoxins (Toxin A and Toxin B), which are the prototypes of the family of large clostridial cytotoxins. Clostridium difficile A and B are high molecular weight glucosyltransferases that inhibit members of the Rho family of GTPases. Toxin A, referred to as an enterotoxin, has a molecular weight of 300 kDa and a pl of 5.3. Toxin B, known as a cytotoxin, has a molecular weight of 270 kDa and a pl of 4.1. By inhibition of signal transduction cascades, Toxin A and Toxin B are able to block downstream responses. Only Toxin A has been shown to have a binding site on epithelial cell surface carbohydrates which may be linked to a dramatic reaction seen in rabbit ileum.