Protein Purification
MilliporeSigma™ Calbiochem™ DAPK Inhibitor
The DAPK Inhibitor, also referenced under CAS 315694-89-4, controls the biological activity of DAPK.
MilliporeSigma™ Calbiochem™ EST
A cell-permeable, irreversible inhibitor of cysteine proteases.
MilliporeSigma™ Calbiochem™ Flt-3 Inhibitor
The Flt-3 Inhibitor, also referenced under CAS 301305-73-7, controls the biological activity of Flt-3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ Kenpaullone
A potent, cell-permeable, and reversible inhibitor of glycogen synthase kinase-3β (IC50 = 230 nM), Lck (IC50 = 470 nM), and cyclin-dependent kinases (Cdks).
MilliporeSigma™ Calbiochem™ EGFR Inhibitor
The EGFR Inhibitor, also referenced under CAS 879127-07-8, controls the biological activity of EGFR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ Dynamin Inhibitor II, MiTMAB
The Dynamin Inhibitor II, MiTMAB, also referenced under CAS 1119-97-7, controls the biological activity of Dynamin. This small molecule/inhibitor is primarily used for Membrane applications.
MilliporeSigma™ Calbiochem™ IRE1 Inhibitor III, 4μ8C
IRE1 Inhibitor III, , CAS 14003-96-4, is a cell-permeable. Covalent inhibitor of IRE1 RNase activity (IC50 = 550 and 45 nM, respectively, with 0 & 16 min preincubation in RNA cleavage assays).
MilliporeSigma™ Calbiochem™ Importazole
A cell-permeable diaminoquinazoline compound that selectively blocks importin-β-mediated nuclear import of NLS bearing cargos in a reversible manner.
MilliporeSigma™ Calbiochem™ SKP2 E3 Ligase Inhibitor III
A cell-permeable benzothiazolylchromenone compound that disrupts Skp2-Skp1 interaction via direct Skp2 affinity binding and selectively prevents Skp2-, but not Fbw7- or β-TrCP-, Skp1-Cullin-1-F-box (SFC) complex-mediated substrates ubiquitination, effectively preventing Skp2 substrates activation (Akt) and degradation (p21 & p27) with concomitant down-regulation of cellular Skp2 protein level (10 to 20μM in HEK293T & PC3 cultures)
MilliporeSigma™ Calbiochem™ IKKε/TBK1 Inhibitor II, MRT67307
A cell-permeable, potent, ATP-competitive, and reversible dual kinase inhibitor of TBK1/IKKε (IC50 = 19 and 160 nM, respectively).
MilliporeSigma™ Calbiochem™ Beclin-1 Activator I, TAT-Beclin-1, Scrambled
A randomly shuffled Beclin-1 (267-284) peptide made cell-permeable by covalently attaching to HIV-1 Tat protein transduction domain via a diglycine linker
MilliporeSigma™ Calbiochem™ JAK2 Inhibitor X, FLLL32
A cell permeable analog of curcumin that acts as a specific inhibitor of JAK2 (≈5 μM) and blocks STAT3 phosphorylation in MDA-MB-231 and PANC-1 cancer cells.
Thermo Scientific™ CaptureSelect™ CH1-XL Magnetic Agarose Beads
Thermo Scientific™ CaptureSelect™ CH1-XL Magnetic Agarose Beads are high-capacity, high-throughput magnetic affinity particles for antibody purification using manual or robotic magnetic separators.
Thermo Scientific™ POROS™ CaptureSelect™ IgM-XL Affinity Matrix
Thermo Scientific™ POROS™ CaptureSelect™ IgM-XL Affinity Matrix is intended for the purification of human IgM, with no binding to other immunoglobulins.
Cytiva Sephadex™ G15 Media
Gel filtration medium for desalting and buffer exchange for small biomolecules greater than 1500 molecular weight