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The Izon Exoid (EX1) is an innovative nanoparticle measurement device designed for superior characterization of complex biological and nanomedicine samples. It utilizes advanced Tunable Resistive Pulse Sensing (TRPS) technology to offer high-resolution single-particle measurements, making it a significant upgrade over traditional methods. The semi-automated device streamlines workflows, improving usability and sensitivity for a variety of nanoparticle types. It is certified to ISO 13485:2016 standards, ensuring quality and reliability in data collection for research applications.
Technology based on Tunable Resistive Pulse Sensing (TRPS)
Capable of measuring particle size, concentration, and zeta potential
Resolution focused on single particle data
Size range of 40 nm to 11 μm
Concentration range from 1E5 to 1E11 particles/mL
Compatible with externa...
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DNA2 inhibitor C5 is a potent, competitive, and specific DNA2 nuclease inhibitor with an IC50 of 20 μM. It inhibits the nuclease, DNA-dependent ATPase, helicase, and DNA-binding activities of DNA2. This product can be used in breast cancer and colorectal cancer research. It is for research use only and not sold to patients.
Potent, competitive, and specific DNA2 nuclease inhibitor
Inhibits nuclease, DNA-dependent ATPase, helicase, and DNA-binding activities of DNA2
Useful in breast cancer and colorectal cancer research
Exhibits strong synergistic effect in inhibiting MCF7 cell survival with MK4827
Shows synthetic lethality with deficiencies in FEN1, EXO1, or MRE11 genes in mouse model
IC50 of 20 μM for DNA2 nuclease
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An inhibitor of PI4KIIIβ (IC50 = 19 nM); ~100-fold selective for PI4KIIIβ over PI4KIIα, PI4KIIβ, and PI4KIIIα, PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ, and PI3KC3, as well as 100-500-fold selective over PI3KC2α, PI3KC2β, and PI3KC2γ
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Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Sovaprevir is a non-structural 3 (NS3) protease inhibitor with antiviral activity for the treatment of HCV infection. purity: 98%
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A potent, cell-permeable, reversible inhibitor of IKK2 (IC50 = 13 nM); used to evaluate the role of the canonical, IκB-dependent NF-κB signaling pathway in cellular responses
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Blocks Tie2 kinase activity (Ki = 1.3 µM), inhibiting angiopoietin 1-induced Tie2 autophosphorylation and downstream signaling (IC50 = 0.3 µM); prevents endothelial cell tube formation and aberrant vessel growth in a rat model of Matrigel-induced choroidal neovascularization
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Activates Ca2+-insensitive PKC isotypes δ, ε and η. Activates Akt/PKB by direct interaction with the Akt PH domain. Purity: ≥98% (NMR). Solubility: Soluble in chloroform/methanol/water, 50:50:10 (10mg/ml); not water soluble but resuspends, with vigorous vortexing, to ~0.5 mg/ml in water. See references for method of incorporation into mixed lipid vesicles by sonication, and for dissolving in a detergent-containing buffer. Long Term Storage: -20°C.
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A research-grade small-molecule inhibitor of coronavirus 3C-like protease (3CLpro/Mpro) with potent biochemical activity; used as an active metabolite in antiviral research and as a reference compound for protease-inhibitor studies.
Potent inhibition of SARS-CoV-2 3CLpro (IC50 0.27 nM) and SARS-CoV-1 3CLpro (IC50 4 nM).
Used as active metabolite and reference standard in antiviral research.
Molecular formula C24H32N4O6; molecular weight 472.53 g·mol-1.
Supplied as a solid with high purity (99.31%).
Storage: powder at -20°C; in solvent -80°C for 6 months or -20°C for 1 month.
Suitable for biochemical assays and preclinical studies.
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More