Protease Inhibitors and Phosphatase Inhibitors
Enzo Life Sciences Tyrphostin AG 1478 (5mg). CAS: 153436-53-4
EGFR inhibitor. Potent and selective inhibitor of EGFR (IC50 = 3nM). Reduces EGF-stimulated DNA synthesis in Rat-1 fibroblasts by ~75% at 0.25μM. Blocks EGF-dependent src-family kinase activation and p21/Cip 1/WAF1 induction in A431 cells. Also inhibits H2O2-induced stimulation of amphiregulin expression in rat gastric epithelium (RGM 1) cells. Alternative name: 4-(3-Chloroanilino)-6,7-dimethoxyquinazoline. Formula: C16H14ClN3O2. MW: 315.8. Purity: ≥98% (HPLC). Appearance: White to light yellow solid. Solubility: Soluble in DMSO (10mg/ml). Long Term Storage: -20°C. Handling: Protect from light. Packaged under inert gas.
Cayman Chemical GSK3 InhIbItr 1 50mg
A GSK3β inhibitor (IC50 = 4.19 nM); decreases blood glucose levels in an OGTT in a rat model of high-fat diet and STZ-induced diabetes at 50 mg/kg
Selleck Chemical LLC CP-673451 10mM/1mL 343787-29-1
CP-673451 is a selective inhibitor of PDGFR?/? with IC50 of 10 nM/1 nM in cell-free assays, exhibits >450-fold selectivity over other angiogenic receptors, has antiangiogenic and antitumor activity. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Cayman Chemical IRAK14 InhIbItr 1mg
A benzimidazole that selectively disrupts the activity of IRAK 1 and 4 (IC50 = 0.3 and 0.2 µM, respectively)
Cayman Chemical mP InhIbItr ItrIfluoroace 1mg
An inhibitor of MMP-1, MMP-2, and MMP-3 (IC50s = 1.3, 30, and 150 μM, respectively); selective for MMP-1, MMP-2, and MMP-3 over the proteases thermolysin, urease, trypsin, α-chymotrypsin, plasmin, and elastase (4 mM)
Cayman Chemical PRMT4CARM1 InhIbItr 5mg
A selective inhibitor of PRMT4/CARM1 (IC50 = 7.1 µM); reduces the prostate-specific antigen promoter activity in human prostate cancer LNCaP cells
Cayman Chemical COX InhIbItr Screeng asy 1ea
An accessory for the Precellys Evolution Touch (Item No. 38707)
FOCUS BIOMOLECULES Biochemical Reagents, CHIR-99021, GSK3beta inhibitor, CAS 252917-06-9, 99% by TLC/NMR (conforms)
Biochemical Reagents, CHIR-99021, GSK3beta inhibitor, CAS 252917-06-9, 99% by TLC/NMR (conforms), Potent and selective inhibitor of glycogen synthase kinase-3beta (GSK3beta, IC50 5 nM) and GSK3alpha (IC50 10 nM)1. Induces osteoblastogenesis, increases mineralization and inhibits adipogenesis in ST2 cells2. Promotes replication and survival of pancreatic beta cells3.Enhances differentiation and reduces proliferation of adult human olfactory epithelium neural precursors4. Cell permeable and active in vivo.
Cayman Chemical CathepsIn G InhIbItr I 1mg
A cathepsin G inhibitor (IC50 = 53 nM); selective for cathepsin G over thrombin, Factor Xa, Factor IXa, plasmin, trypsin, and PR3 (IC50s = >100 µM for all), but also weakly inhibits chymotrypsin; inhibits cathepsin G-induced activation of IL-36 in neutrophil degranulates at 10 µM; reduces CD4+ T cell-induced secretion of IFN-γ and IL-17 in B cells incubated with TTC and also reduces TTC presentation in B cells at 10 µM; decreases the size of neuromyelitis optica lesions and reduces the number of perivascular neutrophils when used in combination with sivelestat in a mouse model of IgG-induced brain injury at 5 UG/animal
Cayman Chemical Syk InhIbItr IIhydrochlorI 1mg
A cell-permeable, selective, and reversible inhibitor of Syk (IC50 = 41 nM); prevents FcεRI-mediated 5-HT release in RBL-2H3 cells in vitro (IC50 = 460 nM) and inhibits passive cutaneous anaphylaxis reactions in mice (ID50 = 13.2 mg/kg, s.c.)
Selleck Chemical LLC AT7519 25mg 844442-38-2
AT7519 is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9 with IC50 of 10-210 nM. It is less potent to CDK3 and little active to CDK7. AT7519 also inhibits GSK3? with IC50 of 89 nM. AT7519 induces apoptosis. Phase 2. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Marimastat (BB-2516) 5mg 154039-60-8
Marimastat (BB-2516) is a broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 with IC50 of 3 nM, 5 nM, 6 nM, 9 nM and 13 nM, respectively. Phase 3. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Bioworld Bestatin (Ubenimex), 25 mg
Bestatin (Ubenimex) is a competitive protease inhibitor - a specific inhibitor of aminopeptidase B and leucine aminopeptidase. Alternative name(s)/Synonyms: Ubenimex Chemical Name: N-[(2S,3R)-3-Amino-2-hydroxy-1-oxo-4-phenylbutyl]-L-leucine Biological Activity: Aminopeptidase inhibitor (Ki = 0.001-90 mM); inhibits enkephalin metabolism and leukotriene A4 hydrolase. Inhibits tumor cell proliferation.
Apexbio Technology LLC Irriversible cysteine protease inhibitor 66701-25-5. MFCD00080261
Irriversible cysteine protease inhibitor 66701-25-5. MFCD00080261