Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ NDGA
A cell-permeable antioxidant and a selective lipoxygenase (LOX) inhibitor (IC50 = 200 nM, 30 μM, and 30 μM for 5-LOX, 12-LOX, and 15-LOX, respectively) over cyclooxygenase (IC50 = 100 μM).
MilliporeSigma™ Calbiochem™ Ro-31-8425
A potent, cell-permeable, reversible, ATP-competitive, and selective protein kinase C inhibitor (IC50 = 15 nM for rat brain PKC).
MilliporeSigma™ Calbiochem™ Rho Kinase Inhibitor
The Rho kinase inhibitor, CAS 872543-07-6, is a cell-permeable, highly specific, reversible, potent, and ATP-competitive inhibitor of Rho-associated kinase (ROCK; Ki = 1.6 nM).
MilliporeSigma™ Calbiochem™ β-Secretase Substrate VI, Fluorogenic
A highly selective, fluorescence resonance energy transfer (FRET) peptide substrate for β-secretase (BACE); (pH ∽4.0, k
Oxymetazoline Hydrochloride, USP, Spectrum™ Chemical
O1359, 2315-02-8, C16H24N2O·HCl
MilliporeSigma™ Calbiochem™ TLR4 Inhibitor, TAK-242
TAK-242; CAS 243984-11-4; is a cell-permeable compound that selectively binds to Cys747 of TLR4 and selectively disrupts its interaction with adaptor molecules TIRAP and TRAM.
MilliporeSigma™ Calbiochem™ Citalopram Hydrobromide
A potent uptake inhibitor highly selective for 5-HT transporter without effect on noradrenalin or dopamine uptake (IC50
MilliporeSigma™ Calbiochem™ MG-132, ≥95% by HPLC
Potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM).
MilliporeSigma™ Calbiochem™ PDGFR Tyrosine Kinase Inhibitor V
The PDGFR Tyrosine Kinase Inhibitor V, also referenced under CAS 347155-76-4, controls the biological activity of PDGFR Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphorylation and Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ Histone Lysine Methyltransferase Inhibitor
The Histone Lysine Methyltransferase Inhibitor, also referenced under CAS 935693-62-2, controls the biological activity of Histone Lysine Methyltransferase. This small molecule/inhibitor is primarily used for Cancer applications.
MilliporeSigma™ Calbiochem™ p53-Snail binding Inhibitor, GN25
The p53-Snail binding Inhibitor, GN25 controls the biological activity of p53-Snail. This small molecule/inhibitor is primarily used for Neuroscience applications.
MilliporeSigma™ Calbiochem™ PDE4D Inhibitor, GEBR-7b
The PDE4D Inhibitor, GEBR-7b controls the biological activity of PDE4D. This small molecule/inhibitor is primarily used for Cell Signaling applications.
MilliporeSigma™ Calbiochem™ BAY 11-7082
The BAY 11-7082, also referenced under CAS 19542-67-7, controls the biological activity of TNF-α. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
MilliporeSigma™ Calbiochem™ Adenosine 3',5'-cyclic Monophosphate, 8-(4-Chlorophenylthio)-, Sodium Salt
Cell-permeable cAMP analog that activates both protein kinase A and protein kinase G.
MilliporeSigma™ Calbiochem™ Adenylyl Cyclase Type V Inhibitor, NKY80
The Adenylyl Cyclase Type V Inhibitor, NKY80, also referenced under CAS 299442-43-6, controls the biological activity of Adenylyl Cyclase Type V.