Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ HIF Prolyl Hydroxylase Inhibitor
A cell-permeable, hydroxyquinoline HIF Prolyl Hydroxylase (PHD) inhibitor that displays an IC50 = 2μM in a cell-based assay using a reporter produced by fusing HIF-1α oxygen degradable domain (ODD) to lucifer
MilliporeSigma™ Calbiochem™ Fluvastatin, Sodium Salt
A synthetic HMG-CoA reductase inhibitor (IC50 = 40-100 nM for human liver microsomes) that acts as an anti-hypercholesterolemic agent.
MilliporeSigma™ Calbiochem™ Gemcitabine, HCl
A bioavailable, moderately toxic, deoxyctytidine analog with anti-metabolite and anti-tumor properties
MilliporeSigma™ Calbiochem™ InSolution™ Paclitaxel, Taxus sp.
Antitumor and anti-leukemic agent isolated from the bark of the yew tree
MilliporeSigma™ Calbiochem™ Histone Lysine Methyltransferase Inhibitor
The Histone Lysine Methyltransferase Inhibitor, also referenced under CAS 935693-62-2, controls the biological activity of Histone Lysine Methyltransferase. This small molecule/inhibitor is primarily used for Cancer applications.
MilliporeSigma™ Calbiochem™ 4α-Phorbol-12,13-didecanoate
Inactive on mouse skin as an inflammatory and tumor-promoting agent.
MilliporeSigma™ Calbiochem™ NF-κB Activation Inhibitor II, JSH-23
The NF-κB Activation Inhibitor II, JSH-23, also referenced under CAS 749886-87-1, controls the biological activity of NF-κB. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
MilliporeSigma™ Calbiochem™ PTP CD45 Inhibitor
The PTP CD45 Inhibitor, also referenced under CAS 345630-40-2, controls the biological activity of PTP CD45. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ 3,4-Dichloroisocoumarin
A potent irreversible inhibitor of serine proteases
MilliporeSigma™ Calbiochem™ 1,2-Dioctanoyl-sn-glycerol
Cell-permeable activator of protein kinase C (PKC).
MilliporeSigma™ Calbiochem™ Caspase-5 Inhibitor I
Z-WEHD-FMK is a cell-permeable, potent, irreversible caspase-5 inhibitor, that also inhibits the activity of Caspase 1, 4, and 8.
MilliporeSigma™ Calbiochem™ STAT5 Inhibitor II, IQDMA
The STAT5 Inhibitor II, IQDMA controls the biological activity of STAT5.
MilliporeSigma™ Calbiochem™ PPARγ Antagonist III, G3335
The PPARγ Antagonist III, G3335, also referenced under CAS 36099-95-3, controls the biological activity of PPARγ.
MilliporeSigma™ Calbiochem™ PDE4D Inhibitor, GEBR-7b
The PDE4D Inhibitor, GEBR-7b controls the biological activity of PDE4D. This small molecule/inhibitor is primarily used for Cell Signaling applications.
MilliporeSigma™ Calbiochem™ InSolution™ ATM Kinase Inhibitor
The InSolution™ ATM Kinase Inhibitor controls the biological activity of ATM Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.