Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ H-89, Dihydrochloride
A cell-permeable, selective, reversible, ATP-competitive and potent inhibitor of protein kinase A (Ki = 48 nM).
MilliporeSigma™ Calbiochem™ InSolution™ H-89, Dihydrochloride
InSolution™ H-89, Dihydrochloride, CAS 127243-85-0, is a 10mm solution of H-89, 2HCl in DMSO. A cell-permeable, potent, reversible, ATP-competitive inhibitor of protein kinase A (Ki = 48nM).
MilliporeSigma™ Calbiochem™ 3-Isobutyl-1-methylxanthine
A cell-permeable, non-specific inhibitor of cAMP and cGMP phosphodiesterases (IC50 = 2-50 μM).
MilliporeSigma™ Calbiochem™ InSolution™ JAK Inhibitor I
The InSolution™ JAK Inhibitor I, also referenced under CAS 457081-03-7, controls the biological activity of JAK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ 5-Fluoro-2'-deoxyuridine
Experimental anticancer agent shown to have activity against a variety of malignant neoplasms, including mouse mammary tumors and colorectal carcinomas.
MilliporeSigma™ Calbiochem™ ET-18-OCH3
A cell-permeable and reversible cytotoxic agent that shows selective cytocidal activity against neoplastic cells and virally transformed cells.
MilliporeSigma™ Calbiochem™ Formyl Peptide Receptor-Like 1 Antagonist, WRW4
The Formyl Peptide Receptor-Like 1 Antagonist, WRW4 controls the biological activity of Formyl Peptide Receptor-Like 1.
MilliporeSigma™ Calbiochem™ Fatostatin
A cell-permeable diarylthiazole compound that prevents the cellular activation of the SREBP-1/2 precursors to the active nuclear forms by blocking SREBPs-SCAP ER to Golgi translocation.
MilliporeSigma™ Calbiochem™ Fucosyltransferase Inhibitor, 2F-Peracetyl-Fucose
2F-Peracetyl-Fucose is a cell-permeable fluorinated fucose derivative that acts as an inhibitor of fucosyltransferases following its uptake and metabolic transformation into a GDP-fucose mimetic.
MilliporeSigma™ Calbiochem™ N-Ethylmaleimide
Sulfhydryl alkylating reagent that inhibits H+-ATPase and suppresses the short circuit current (IC50 = 22 μM) in pancreatic duct cells.
MilliporeSigma™ Calbiochem™ Foxo1 Inhibitor, AS1842856
Foxo1 Inhibitor, AS1842856, is a cell-permeable inhibitor that blocks the transcription activity of Foxo1 (IC50 = 33 nM). Directly binds to the active Foxo1, but not the Ser256-phosphorylated form.
MilliporeSigma™ Calbiochem™ BLM Helicase Inhibitor, ML216
A cell-permeable pyridinyl-thiadiazolylurea compound that selectively blocks Bloom's syndrome protein (BLM) helicase activity of both full-length as well as truncated BLM636-1298 forms (IC50
MilliporeSigma™ Calbiochem™ PD 150606
A cell-permeable, non-competitive, selective non-peptide calpain inhibitor [Ki = 210 nM for calpain-1 and 370 nM for calpain-2.
MilliporeSigma™ Calbiochem™ Parthenolide, Tanacetum parthenium
A cell-permeable sesquiterpene lactone with anti-inflammatory, antisecretory, and spasmolytic properties.
MilliporeSigma™ Calbiochem™ PD 174265
A potent, cell-permeable, reversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50 = 450 pM).