Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ Pancuronium Dibromide
A highly potent competitive antagonist selective for nAChRs (IC50
MilliporeSigma™ Calbiochem™ NG,NG'-Dimethyl-L-arginine, Dihydrochloride
Cell permeable. Endogenous inhibitor of nitric oxide synthesis in vitro and in vivo. Does not exhibit any significant inhibitory effect on NOS activity.
MilliporeSigma™ Calbiochem™ Porcn Inhibitor IV, LGK974
A cell-permeable inhibitor of Wnt secretion from L-cell Wnt1/2/3/3a/6/7a/9a transfectants (IC50 from 50 pM to 1.1 nM).
MilliporeSigma™ Calbiochem™ PKM2 Activator IV, TEPP-46
A cell-permeable, potent, allosteric activator of PKM2 (AC50 = 92 nM).
MilliporeSigma™ Calbiochem™ InSolution™ Nutlin-3, Racemic
A cell-permeable, potent, and selective MDM2 antagonist (IC50 = 90nM for Nutlin-3a and 13
MilliporeSigma™ Calbiochem™ IRAP Inhibitor, HFI-419
A substrate competitive inhibitor of insulin-regulated aminopeptidase (IRAP) activity (Ki = 0.48 μM against 25 μM Leu-AMC).
MilliporeSigma™ Calbiochem™ Mycophenolic Acid
An immunosuppressive agent that inhibits de novo purine nucleotide synthesis via inhibition of inosine monophosphate dehydrogenase and prevents the formation of XMP and GMP.
MilliporeSigma™ Calbiochem™ Okadaic Acid, Potassium Salt
Water-soluble analog of Okadaic Acid. Inhibits protein phosphatases 1 and 2A.
MilliporeSigma™ Calbiochem™ Myeloperoxidase Inhibitor-I
The Myeloperoxidase Inhibitor-I, also referenced under CAS 5351-17-7, controls the biological activity of Myeloperoxidase. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
MilliporeSigma™ Calbiochem™ InSolution™ Nocodazole
Inhibitor of mitosis. Has highly specific antimicrotubular activity for mammalian cells in culture.
MilliporeSigma™ Calbiochem™ InSolution™ Latrunculin A, Latrunculia magnifica
A cell-permeable marine toxin from the Red Sea sponge Latrunculia magnifica that disrupts microfilament organization in cultured cells by the formation of a 1:1 complex with monomeric G-actin (Kd = 200nM)
MilliporeSigma™ Calbiochem™ AP-1/NF-κB Dual Inhibitor, SP100030
A cell-permeable, non-toxic, conformationally restricted pyrimidinecarboxamide compound that acts as a potent, reversible T-cell specific inhibitor of both AP-1 and NF-κB transcriptional activation (IC50 = 50
MilliporeSigma™ Calbiochem™ BMX/BTK Inhibitor II, QL47
A cell-permeable, highly potent, selective, irreversible inhibitor of BTK (IC50 = 6.6 nM).
MilliporeSigma™ Calbiochem™ PrCP Inhibitor
A dichlorobenzimidazolopyrrolidinamide compound
MilliporeSigma™ Calbiochem™ PKA Inhibitor 5-24
The PKA Inhibitor 5-24, also referenced under CAS 99534-03-9, controls the biological activity of PKA.