Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ D-Val-Phe-Lys Chloromethyl Ketone, Dihydrochloride
Selective irreversible inhibitor of plasmin with high selectivity for plasmin (IC50 = 100 pM for human plasmin) over urokinase.
MilliporeSigma™ Calbiochem™ Bax-Inhibiting Peptide, Negative Control
A cell-permeable negative control of the Bax-Inhibiting Peptide, V5. Does not suppress Bax-mediated apoptosis (≈200 μM).
MilliporeSigma™ Calbiochem™ MPNST Inhibitor, Cpd21
A cell-permeable. Reversible, selective inhibitor of the growth of malignant peripheral nerve sheath tumors (EC50 = 439 nM, 754 nM, and 1.0 μM in S462, SNF96.2, and sMPNST cells).
MilliporeSigma™ Calbiochem™ AP-1/NF-κB Dual Inhibitor, SP100030
A cell-permeable, non-toxic, conformationally restricted pyrimidinecarboxamide compound that acts as a potent, reversible T-cell specific inhibitor of both AP-1 and NF-κB transcriptional activation (IC50 = 50
MilliporeSigma™ Calbiochem™ Calcineurin Substrate
An excellent peptide substrate for calcineurin.
MilliporeSigma™ Calbiochem™ Myristoylated-FEEERA, mP6
A cell-permeable myristoylated hexapeptide that selectively inhibits integrin outside-in signaling without affecting inside-out signaling. Blocks the interaction of Gα3 and integrin β3 subunit.
MilliporeSigma™ Calbiochem™ LIM Kinase Inhibitor I, LIMKi 3
The LIM Kinase Inhibitor I, LIMKi 3 controls the biological activity of LIM Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ PARP Inhibitor VI, NU1025
The PARP Inhibitor VI, NU1025, also referenced under CAS 90417-38-2, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.
MilliporeSigma™ Calbiochem™ I-BET
A cell-permeable benzodiazepine compound that binds the tandem bromodomains of BET (bromodomain and extra terminal domain) family members BRD2 (1-473), BRD3 (1-434), and BRD4 (1-477) with high affinity.
MilliporeSigma™ Calbiochem™ STAT3 Inhibitor IX, Cpd188
The STAT3 Inhibitor IX, Cpd188, also referenced under CAS 823828-18-8, controls the biological activity of STAT3.
MilliporeSigma™ Calbiochem™ Protein Methyltransferase Inhibitor, AMI-5
The Protein Methyltransferase Inhibitor, AMI-5, also referenced under CAS 17372-87-1, controls the biological activity of Protein Methyltransferase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
MilliporeSigma™ Calbiochem™ TACE Substrate IV, Fluorogenic
An internally-quenched fluorogenic decapeptide substrate that is useful for continuous monitoring of TACE activity and high-throughput screening of TACE inhibitors (kcat =
MilliporeSigma™ Calbiochem™ Calpain Substrate III, Fluorogenic
A fluorogenic FRET peptide with a substrate sequence that is optimized for calpain-1 and -2.
MilliporeSigma™ Calbiochem™ ATR Kinase Inhibitor II
A cell-permeable aminopyrazinyl-sulfone compound that acts as a potent, reversible and ATP-competitive inhibitor of ATR kinase (IC50 = 12nM; Ki = 6nM) with excellent selectivity over ATM, DNA-PK (IC50 > 8μM) and in a 50-kinase panel (% inhibition at 2μM = 59, 57, 55, 52, 43 and 42 for AMPK, Lck, RIPK2, Ret, IKKα and FGFR3, resp
MilliporeSigma™ Calbiochem™ MICAL-2 Inhibitor II, CCG-203971
A cell-permeable, restricted form of CCG-1423 with enhanced potency (IC50 = 4.2 μM vs 16.6 μM for PC-3 cell migration), but reduced off-target toxicity.