Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ HMTase Inhibitor IX, MM-102
A cell-permeable peptidomimetic that prevents MLL1 (Mixed Lineage Leukemia 1) from complex assembling with WDR5 (Trp-Asp Repeat Domain 5), RbBP5 (Retinoblastoma Binding Protein 5), and ASH2L (Absent Small or Homeotic-2-Like) for enhanced H3K4 methyltransferase activity (IC50
MilliporeSigma™ Calbiochem™ Pamidronate, Disodium Salt
A potent and specific inhibitor of bone resorption that does not cause any significant detrimental effect on bone growth and mineralization at concentrations used.
MilliporeSigma™ Calbiochem™ Celastrol, Celastrus scandens
A cell-permeable dienone-phenolic triterpene compound that exhibits antioxidant and anti-inflammatory properties.
MilliporeSigma™ Calbiochem™ D609, Potassium Salt
Selective inhibitor of phosphatidylcholine (PC)-specific phospholipase C (Ki = 5-10 μM).
MilliporeSigma™ Calbiochem™ Calcium Entry Blocker Set, Pyr6 & Pyr10
A set of PYR6, a CRAC Channel Inhibitor III; and PYR10, a TPRC3 Channel Inhibitor III.
MilliporeSigma™ Calbiochem™ Sphingosine Kinase Inhibitor
The Sphingosine Kinase Inhibitor, also referenced under CAS 1177741-83-1, controls the biological activity of Sphingosine Kinase. This small molecule/inhibitor is primarily used for Cell Signaling applications.
MilliporeSigma™ Calbiochem™ FPT Inhibitor II
The FPT Inhibitor II controls the biological activity of FPT. This small molecule/inhibitor is primarily used for Cancer applications.
MilliporeSigma™ Calbiochem™ Wnt Pathway Inhibitor XI, CCT036477
The Wnt Pathway Inhibitor XI, CCT036477, also referenced under CAS 305372-78-5, controls the biological activity of Wnt Pathway. This small molecule/inhibitor is primarily used for Cancer applications.
MilliporeSigma™ Calbiochem™ Syk Inhibitor
The Spleen Tyrosine Kinase Inhibitor, also referenced under CAS 622387-85-3, controls the biological activity of Spleen Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphorylation and Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ Calpain Inhibitor XI
The Calpain Inhibitor XI, also referenced under CAS 145731-49-3, controls the biological activity of Calpain. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
MilliporeSigma™ Calbiochem™ Bisindolylmaleimide I
A highly selective, cell-permeable, and reversible protein kinase C (PKC) inhibitor (IC50 = 10 nM) that is structurally similar to staurosporine.
MilliporeSigma™ Calbiochem™ Sodium Salicylate
A cell-permeable, non-steroidal anti-inflammatory agent that interferes with TNF-induced NF-κB activation by inhibiting phosphorylation and subsequent degradation of the IκB-α protein.
MilliporeSigma™ Calbiochem™ Tenovin-1
A cell-permeable benzoylthiourea compound that acts as a reversible inhibitor of class III HDAC sirtuins against SirT2 (IC50 = ≈10 μM).
MilliporeSigma™ Calbiochem™ SREBP Processing Inhibitor, Betulin
The SREBP Processing Inhibitor, Betulin, also referenced under CAS 473-98-3, controls the biological activity of SCAP (SREBP cleavage activating protein). This small molecule/inhibitor is primarily used for Cell Signaling applications.
MilliporeSigma™ Calbiochem™ Resveratrol
A phenolic product found in both grape skins and wines.