Tissue Lysates
Cayman Chemical RCS4 N 5carboxypentyl met 1mg
An expected metabolite of RCS-4, which should be detectable in the urine
Cayman Chemical GLP-17-36 acIdhumnmou 1mg
A derivative of GLP-1 (7-36) amide; enhances insulin-induced phosphorylation of Akt in 3T3-L1 adipocytes at 100 nM in the presence of a DPP-4 inhibitor; reduces plasma levels of total cholesterol, triglycerides, free fatty acids, LDL, insulin, and leptin, as well as adipose tissue weight, in a mouse model of high-fat diet-induced obesity at 150 UG/kg; decreases blood glucose levels, food intake, and gastric emptying in non-obese and ob/ob mice at 3 mg/kg
Cayman Chemical PB22 8hydroxyIsoquInolIn I 1mg
A structural isomer of PB-22; intended for forensic and research purposes
Cayman Chemical SynthetIc MIltIron 1mg
A tanshinone; protects lard from thermal oxidation at 0.02%; a partial agonist of the benzodiazepine receptor (IC50 = 0.3 µM); inhibits CES2 (Ki = 0.04 µM) as well as SARS-CoV Mpro and PLpro (IC50s = 21.1 and 30 µM, respectively); cytotoxic to HCT116 colon cancer cells (IC50 = 4.27 µM) and induces mitochondrial dysfunction and ROS production in the same cells; increases the number of punished crossings in the four-plate test, indicating tranquilizing activity, in mice at 10-60 mg/kg
Cayman Chemical SynthetIc GItoxIn 1mg
A cardiac glycoside with cardiotonic and antiarrhythmic activities; inhibits Na+/K+-ATPase in an isoform-specific biphasic manner with IC50 values of 0.298 and 410 µM for the high- and low affinity human erythrocyte isoenzymes, respectively, and 1.18 and 28.5 µM for the high- and low affinity porcine cerebral cortex isoenzymes, respectively; increases contractility and rhythmicity in isolated guinea pig heart in a concentration-dependent manner; a degradation product of digoxin
Cayman Chemical SynthetIc CarubIcIn 1mg
An anthracycline with anticancer activity; cytotoxic to MCF-7 and K562 cells (IC50s = 90 and 60 nM, respectively), as well as P-glycoprotein-expressing MCF-7/DOX and K562i/S9 cells (IC50s = 90 and 60 nM, respectively)
Cayman Chemical 1 3DIpalmItoleoyl Glycerol 1mg
A diacylglycerol with palmitoleic acid at the sn-1 and sn-3 positions; selectively inhibits α-glucosidase from S. cerevisiae over rat enzyme (IC50s = 4.45 and 9,326.5 μM, respectively); has been used in the formation of lipid bilayers to study the effects of membrane composition and valinomycin on membrane potential
Cayman Chemical 1 3-DInonadecnoyl Glycerol 1mg
A diacylglycerol; has been used as a standard in the quantification of diacylglycerols in synthetic milk fat by SPE/HPLC/ELSD
Cayman Chemical SynthetIc Thujopsen 1mg
A sesquiterpene with diverse biological activities; inhibits Na+/K+-ATPase (IC50 = 25.9 UG/ml) and CYP2B6 (Ki = 0.8 µM); active against S. aureus, M. luteus, and S. typhimurium (MICs = 25-50 UG/ml); inhibits antigen-induced β-hexosaminidase release from IgE-sensitized RBL-2H3 mast cells (IC50 = 25.1 µM); cytotoxic to A549 cells (LC50 = 35.27 UG/ml); induces mortality in the mites D. farniae and T. putrescentiae (LC50s = 9.82 and 10.92 UG/cm2, respectively)
Cayman Chemical SynthetIc GosypetIn 1mg
A flavonoid with diverse biological activities; inhibits MKK3 and MKK6, as well as induces apoptosis and cell cycle arrest at the G2 phase in KYSE-450 and KYSE-510 esophageal cancer cells at 20 µM; scavenges DPPH radicals and inhibits copper-induced lipid peroxidation in cell-free assays; reduces high-fat diet-induced increases in serum cholesterol, triglycerides, and LDL-cholesterol levels, as well as decreases aortic extracellular lipid and foam cell deposits in a rabbit model of atherosclerosis at 10 mg/kg
Cayman Chemical 2C-I-FLYhydrochlorIde 1mg
An analytical reference standard categorized as a phenethylamine; induces the head-twitch response in mice; intended for research and forensic applications