Isotype Controls and Standards
Cayman Chemical chartreusIs A23187 25mg
A lipophilic analog of 17-trifluoromethylphenyl trinor PGF2a
Cayman Chemical BGJ398phosphate 25mg
A prenylated coumarin with anti-inflammatory and neuroprotective activities inhibits TPA- and A23187-induced histamine release from HMC-1 cells at 10 UM protects against glutamate-induced cytotoxicity in primary rat cortical cells at 0.1-10 UM
Cayman Chemical 20 R-ProtopnaxatrIol 25mg
A coumarin glucoside inhibits A23187-induced production of PGE2 and LTC4 in isolated mouse peritoneal macrophages at 100 UM reduces synovial inflammation and fibrosis as well as bone and cartilage erosion in the inflamed joints in a complete Freunds adjuvant- and M butyricum-induced rat model of rheumatoid arthritis at 50 and 100 mg/kg
Cayman Chemical RhodojaponIn III 25mg
An inhibitor of H-PGDS (IC50 55 8 nM) selective for H-PGDS over L-PGDS at 100 UM as well as over enzyme and receptor panels at 10 UM inhibits A23187-induced PGD2 production in KU812 and RBL-2H3 basophils (IC50s 78 3 and 181 3 nM respectively) inhibits ovalbumin-induced nasal lavage fluid eosinophil infiltration and late-phase nasal obstruction in an ovalbumin-sensitized guinea pig model of allergic rhinitis at 30 mg/kg
Cayman Chemical ImIdafenacIn 25mg
A dual inhibitor of COX and 5-LO (IC50s 2.84 and 0.15 UM respectively in RBL-1 cell lysates) inhibits the activity of 12- but not 15- LO (IC50s 4.45 and 146.6 UM for the human platelet and rabbit reticulocyte enzymes respectively) reduces A23187-induced TXB2 and LTB4 production in human PBMCs (IC50s 0.01 and 0.07 UM respectively) and decreases epinephrine-induced platelet aggregation in human PRP (IC50 0.045 UM) inhibits paw swelling in a rat model of adjuvant-induced arthritis (ED50 3.5 mg/kg)
Cayman Chemical Cheldonn 25mg
An NSAID and COX inhibitor (IC50s 3 and 9.3 UM for human COX-1 and COX-2 respectively) inhibits TNF-a-induced increases in COX-2 levels and NF-KB activation in HT-29 colon cancer cells in a concentration-dependent manner inhibits fMLP- or A23187-induced calcium influx in PMN (IC50s 29 and 14 UM respectively) activates various ion channels including TRPC6 and KCa1.1 inhibits various ion channels including TRPC3 and CFTR reduces increases in intestinal fluid secretion and intestinal barrier disruption in mice infected with the El Tor variant of V. cholerae at 20 mg/kg
Cayman Chemical TC 2559fumarate 25mg
A naphthoquinone with diverse biological activities inhibits U-46619-induced rabbit platelet aggregation in vitro (IC50 0.58 M) inhibits the conversion of arachidonic acid to thromboxane B2 in rabbit platelets inhibits human platelet aggregation induced by ADP collagen epinephrine and A23187 in vitro (IC50s 3.21 15.69 8.44 and 44.2 M respectively) increases tail bleeding time and exhibits a protective effect against pulmonary thrombosis in mice at 50 and 100 mg/kg inhibits CD45 (IC50 0.29 M) inhibits ovalbumin-induced footpad swelling in a mouse model of delayed-type hypersensitivity at 3 mg/kg is active against C. albicans A. niger B. subtilis S. aureus E. coli and P. aeruginosa (MICs 12.5-50 g/ml)