Substrates
Medchemexpress LLC Her2/CD340 protein, canine (HEK293, His) | >95.0% | 100 UG
HER2/CD340 Protein, Canine (HEK293, His) is a recombinant, partially truncated canine ErbB2 extracellular domain produced in HEK293 mammalian cells and supplied as a C-terminal His-tagged, lyophilized protein for research applications. It is suitable for biochemical and cell-based assays, including binding and functional activity measurements.
- Recombinant partial extracellular domain (T23-T652) expressed in HEK293 cells.
- C-terminal His tag for purification and detection.
- Supplied lyophilized for extended stability.
- Purity greater than 95% as determined by reducing SDS-PAGE.
- Low endotoxin level (<1 EU/μg), suitable for sensitive assays.
- Store at -20°C; after reconstitution stable 4°C for 1 week or -20°C for long-term storage.
- Demonstrated biological activity with ED50 0.4594 μg/mL in the presence of 0.6 μg/mL trastuzumab.
CPC Scientific DABCYL-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser-Arg-EDANS (trifluoroacetate salt) 0.5MG
TACE FRET substrate I that is derived from the cleavage sequence of pro-TNFa recognized by the TNFa-cleaving enzyme (TACE). TNFa is presumably shed from cell membranes by TNFa-cleaving enzyme (TACE). Incubation of the TACE substrate with recombinant human TACE gives a specific cleavage to restore the quenched fluorescence. The substrate is widely used to screen inhibitors of TNF-convertase.ONE-LETTER SEQUENCE: Dabcyl-LAQAVRSSSR-EDANSMOLECULAR FORMULA: C70H104N22O18S1MOLECULAR WEIGHT:1573.80STORAGE CONDITIONS: -20 5C, CAS REGISTRY NUMBER: [396716-14-6], SYNONYMS: DABCYL-TNF--EDANS (-4 to +6) (human)RESEARCH AREA: ApoptosisREFERENCES: A.J. H.Gearing et al., Nature , 370, 555 (1994); K.M. Mohler et al., Nature , 370, 218 (1994); Becker BF, et al.Biol Chem 383, 1821-6 (2002); Mohler KM, et al., Nature 370, 218-20. (1994);
Biotium HER-2 / CD340(ERB2/776), CF740 conjugate, 0.1mg/mL
This MAb is specific to c-erbB-2/HER-2 and shows minimal cross-reaction with other members of the family. C-erbB-2/HER-2 is a member of the EGFR family. Receptors of this family are located on the plasma membrane and consist of an extracellular ligand-binding domain that is connected to a large intracellular domain by a single transmembrane sequence. c-erbB-2/HER-2 protein is over-expressed in a variety of carcinomas especially those of breast and ovary.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Medchemexpress LLC Ac-YEVD-AMC | 1631716-11-4 | 99.6% | 723.73 | 5 MG
Ac-YEVD-AMC is a fluorescent substrate of caspase-1/11 that releases amino-4-methylcoumarin (AMC) for fluorescence detection when treated with cell lysate. This product is for research use only.
- Fluorescent substrate of caspase-1/11
- Releases amino-4-methylcoumarin (AMC) for fluorescence detection
- For research use only
Medchemexpress LLC Ac-IETD-AFC | 211990-57-7 | 99.3% | 729.65 | 10 MG
Ac-IETD-AFC is a fluorogenic substrate for caspases-8, -3, and -10, as well as granzyme B. This product is intended for research use only and is not sold to patients.
- Fluorogenic substrate for caspase-8, caspase-3, caspase-10, and granzyme B
- Suitable for enzyme labeling and fluorescence studies
- Used in apoptosis and caspase research
- Excitation wavelength less than 380 nm
- Emission wavelength 496-570 nm (green)
Medchemexpress LLC Z-Gly-Gly-Arg-AMC acetate | 2070009-61-7 | 99.84% | 639.66 | 50 MG
Z-Gly-Gly-Arg-AMC acetate is a thrombin-specific fluorogenic substrate primarily used for testing thrombin generation in both platelet-rich plasma (PRP) and platelet-poor plasma (PPP). This compound, characterized by excitation/emission wavelengths of 390/480 nm, is provided as a solid, typically white to off-white, and is strictly for research applications.
- Thrombin-specific fluorogenic substrate
- Suitable for thrombin generation assays in PRP and PPP
- Exhibits excitation at 390 nm and emission at 480 nm
- Supplied as a white to off-white solid
- Intended for research use only
Abcam 4-Trifluoromethylumbelliferyl oleate, 10MG
MW 494.6 Da. Fluorescent lipase substrate. Releases highly fluorescent 4-trifluoromethylumbelliferone upon hydrolysis. 4-trifluoromethylumbelliferone is insensitive to pH making it suitable for use in food analysis.
The product is subject to the following: Abcam Restricted Use Statement
AdipoGen Ac-Arg-Leu-Arg-AMC (5 mg)
Ac-Arg-Leu-Arg-AMC (5 mg), AdipoGen Life Sciences. Chemical. CAS: 929903-87-7 (free base). Formula: C30H46N10O6 . C2HF3O2. MW: 642.8 . 114.0. Fluorogenic tri-peptide substrate for measuring the trypsin-like peptidase activity of the 20S proteasome. It is cleaved exclusively at the amide R-AMC bond to release fluorescent product. Shows low Km and high specific activity. Excitation: 380nm. Emission: 460nm. This substrate is useful for inhibitor screening and kinetic analysis.
Abcam PAP-AMC, Tyrosinase substrate, Fluorogenic tyrosinase substrate, 100UG
MW 310.3 g/mol, Purity >98%. Fluorogenic tyrosinase substrate. Achieve your results faster with highly validated, pure and trusted compounds.
The product is subject to the following: Abcam Restricted Use Statement
![AdipoGen Ac-Trp-Leu-Ala-AMC [Ac-WLA-AMC] (2 mg)](https://assets.fishersci.com/TFS-Assets/CCG/product-images/501490624.PNG-250.jpg)
AdipoGen Ac-Trp-Leu-Ala-AMC [Ac-WLA-AMC] (2 mg)
Ac-Trp-Leu-Ala-AMC [Ac-WLA-AMC] (2 mg), AdipoGen Life Sciences. Chemical. CAS: 1104011-59-7. Formula: C32H37N5O6. MW: 587.7. Synthetic. Ac-WLA-AMC is a fluorogenic peptid substrate for measuring chymotrypsin-like activity of the proteasome. Hydrolysis of this substrate by the beta5-subunit of the 20S proteasome is monitored by observing fluorescence at an Excitation wavelength of 345nm and Emission at 445nm. This substrate is specific to the constitutive proteasome and is not hydrolyzed efficiently by the immunoproteasome. 20S Proteasome enzyme requires activation with 0.035% SDS in the assay buffer.
Apexbio Technology LLC Boc-Lys(Ac)-AMC 233691-67-3 250mg
Boc-Lys Ac -AMC (CAS 233691-67-3) is a fluorescently labeled peptide substrate designed for analyzing enzymatic activity of histone deacetylases (HDACs) It enables monitoring of HDAC-mediated deacetylation reactions Boc-Lys Ac -AMC exerts its biological activity primarily through acting as a fluorogenic substrate for HDACs where deacetylation leads to subsequent fluorescence release following proteolytic cleavage Based on these properties Boc-Lys Ac -AMC holds research potential in biochemical assays and drug screening studies for characterizing HDAC enzyme kinetics and assessing inhibitor potency related to epigenetic modulation
Medchemexpress LLC 6′-Amino-D-luciferin | 161055-47-6 | 98.5% | 10 MG
6′-Amino-D-luciferin is a derivative of D-luciferin where an amino group replaces the 6-hydroxyl group. It is a natural substrate of luciferase (Luc) and can be used for IVIS imaging in cell/animal experiments. This product is for research use only and not sold to patients.
- Derivative of D-luciferin
- Amino group replaces the 6-hydroxyl group
- Natural substrate of luciferase (Luc)
- Used for IVIS imaging in cell/animal experiments
Sigma Aldrich Fine Chemicals Biosciences N-Hippuryl-His-Leu hydrate powder, >=98% (HPLC) | 207386-83-2 | MFCD00149318 | 100MG
N-Hippuryl-His-Leu hydrate powder, >=98% (HPLC) | Purity: >=98% (HPLC) | 207386-83-2 | MFCD00149318 | 100MG
![Alkali Scientific D Luciferin Potassium Salt [4,5 Dihydro 2 (6 hydroxy 2 benzothiazolyl) 4 thiazolecarboxylic acid, potassium salt], 250 Mg](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000661584.jpg-250.jpg)
Alkali Scientific D Luciferin Potassium Salt [4,5 Dihydro 2 (6 hydroxy 2 benzothiazolyl) 4 thiazolecarboxylic acid, potassium salt], 250 Mg
D-Luciferin Potassium Salt (4,5-Dihydro-2-(6-hydroxy-2-benzothiazolyl)-4-thiazolecarboxylic acid, potassium salt), 250mg, is a bioluminescence reagent widely used in luciferase-based assays. It is commonly employed to detect gene expression, monitor cellular activity, and measure ATP levels using bioluminescence detection methods. The potassium salt form is water-soluble and provides excellent luminescence results, making it ideal for use in high-throughput screening and various biochemical assays. This 250mg size is suitable for laboratories that perform routine bioluminescence assays, offering a cost-effective solution for researchers investigating cellular processes or conducting gene function studies.
Echelon Biosciences Research Labs TACE Substrate (Fluorogenic) - 0.5 mg, CAS#: 396716-14-6
TACE Substrate (Fluorogenic) - 0.5mg , Dabcyl-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser-Arg-EDANS Category/Application: Enzyme Substrates This item is non returnable