Isotopically Labeled Compounds
Medchemexpress LLC Fleroxacin-d3 hydrochloride | 79660-72-3 | 98.8% | 1 MG
Fleroxacin-d3 (hydrochloride) is the deuterium labeled Fleroxacin (hydrochloride). It can be used as a tracer and as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS. Deuteration has gained attention due to its potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Used as a tracer for various analyses.
- Functions as an internal standard for quantitative analysis.
- Useful for NMR, GC-MS, or LC-MS applications.
- Deuteration can impact pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Latanoprost-d4 | 130209-82-4 | 98.0% | 500 UG
Latanoprost-d4 is the deuterium-labeled Latanoprost, a prostaglandin F2α analogue and an agonist for the FP prostanoid receptor, which lowers intraocular pressure (IOP). It serves as a tracer and an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS. Deuteration has the potential to affect the pharmacokinetic and metabolic profiles of drugs, offering valuable insights in research.
- Deuterium labeled compound
- Prostaglandin F2α analogue
- Agonist for FP prostanoid receptor
- Lowers intraocular pressure (IOP)
- Useful as a tracer
- Functions as an internal standard for quantitative analysis
- Can affect pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC Acyclovir-d4 | 1185179-33-2 | 98.7% | 229.23 | C8H7D4N5O3 | 10 MG
Acyclovir-d4 is a deuterium-labeled analogue of the antiviral acyclovir provided for research use. It is intended as a stable-isotope tracer or internal standard for analytical assays and pharmacokinetic studies, enabling accurate quantitation and method validation. The compound is supplied as a high-purity solid suitable for LC-MS/MS and related analytical workflows.
- Deuterium-labeled analog for tracer and internal standard use.
- High purity suitable for analytical assays and method validation.
- Stable solid form with defined storage recommendations.
- Supports quantitative LC-MS/MS and pharmacokinetic analyses.
- Available in small, pre-weighed quantities for method development.
Medchemexpress LLC Fluorenone-d8 | 137219-34-2 | 98% | 188.25 | 1 MG
Fluorenone-d8 is a labeled analogue of 9-Fluorenone, a polycyclic aromatic ketone. It is primarily identified as a laboratory chemical for substance manufacturing and is intended for research use only, not validated for medical applications. This product should be handled by experienced and qualified scientists in appropriately equipped facilities.
- Possesses photosensitizing properties
- Can undergo electrochemical polymerization
- Utilized as an initiator in visible-light cured resin systems
- For research use only
Medchemexpress LLC Triamterene-d5 | 1189922-23-3 | 99.8% | 5 MG
Triamterene-d5 is a deuterium labeled variant of Triamterene. It functions as a mild diuretic by blocking the epithelial Na+ channel (ENaC) in a voltage-dependent manner and is also an inhibitor of the TGR5 receptor. This compound can be used as a tracer or an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner
- Functions as a mild diuretic
- Inhibitor of the TGR5 receptor
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Moxidectin-d3 | 113507-06-5 | 95.2% | 1 MG
Moxidectin-d3 (CL-301423-d3) is a deuterium-labeled version of Moxidectin. Moxidectin is an orally active macrolide (ML) anthelmintic used for the prevention and control of heartworms and roundworms. It is also a substrate of BCRP and P-glycoprotein (P-gp) in vivo, and is secreted into breast milk and effluxed from the host and parasite by Bcrp1 and P-gp.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes of hydrogen, carbon, and other elements are incorporated into drug molecules.
- Deuteration has the potential to influence the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Lamotrigine-13C3,d3 | 1246815-13-3 | 1 MG
Lamotrigine-13C3,d3 is a 13C-labeled version of Lamotrigine, a potent and orally active anticonvulsant or antiepileptic agent. It functions by selectively blocking voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes, and inhibiting glutamate release.
- Useful for research related to epilepsy and focal seizures
- Incorporates stable heavy isotopes as tracers for quantitation
- Potential to affect pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC Nitrendipine-d5 | 2469554-26-3 | 99.8% | 1 MG
Nitrendipine-d5 is a deuterium-labeled version of Nitrendipine, an orally active analog of Nifedipine that functions as a dihydropyridine calcium channel blocker. It has been shown to induce apoptosis and possess antihypertensive effects. Additionally, it can block alcohol and morphine withdrawal symptoms, reduce right ventricular hypertrophy, and alleviate pulmonary vascular changes caused by intermittent hypoxia. It also exhibits anticancer effects on neuroblastoma.
- Application as a tracer
- Internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Deuteration can influence the pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC Nitrendipine-d5 | 2469554-26-3 | 99.77% | 5 MG
Nitrendipine-d5 is a deuterium-labeled version of Nitrendipine, an orally active analog of Nifedipine. It acts as a dihydropyridine calcium channel blocker, shown to induce apoptosis and exhibit antihypertensive effects. Nitrendipine can also block alcohol and morphine withdrawal symptoms, reduce right ventricular hypertrophy and pulmonary vascular changes caused by intermittent hypoxia, and possess anticancer effects on neuroblastoma.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Phenacetin-d5 (Acetophenetidin-d5) | 69323-74-6 | 99.5% | 1 MG
Phenacetin-d5 is a deuterium-labeled form of Phenacetin, a non-opioid analgesic and antipyretic. It acts as a selective COX-3 inhibitor and is utilized as a probe for cytochrome P450 enzymes. This compound is a white to off-white solid with a molecular weight of 184.25 and a chemical formula of C10H8D5NO2.
- Used as a probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuteration has gained attention for its potential to affect the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Ethane-13C2-sulfonic acid, 2-amino- | 70155-54-3 | ≥99.0% | 1 MG
Taurine-13C2 is the 13C-labeled Taurine, a sulfur-containing amino acid and an organic osmolyte crucial for cell volume regulation. It functions as a substrate for bile salt formation and modulates intracellular free calcium concentration, also activating autophagy in adipocytes.
- Intended for research use only
- Can be used as a tracer for quantitative analysis
- Functions as an internal standard for quantitative analysis
- Suitable for NMR, GC-MS, or LC-MS applications
Medchemexpress LLC D-Glucose-13C-4 | 40762-22-9 | 98.0% | 100 MG
D-Glucose-13C-4 is a 13C labeled version of D-Glucose. D-Glucose, a monosaccharide, is a significant carbohydrate in biology. It functions as a carbohydrate sweetener, a vital component of general metabolism, and a crucial signaling molecule involved in cellular metabolic status and responses to biotic and abiotic stress. This product is intended solely for research purposes.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis through methods like NMR, GC-MS, or LC-MS.
- Stable heavy isotopes, such as carbon, are incorporated into drug molecules for quantitation during drug development.
- Deuteration can potentially influence the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Cytidine-13C | 201996-57-8 | 99.0% | 25 MG
Cytidine-13C is the 13C labeled Cytidine. Cytidine is a pyrimidine nucleoside and a component of RNA. It is also a precursor of uridine and controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism and catecholamine.
- 13C labeled Cytidine
- Pyrimidine nucleoside
- Component of RNA
- Precursor of uridine
- Controls neuronal-glial glutamate cycling
- Affects cerebral phospholipid metabolism
- Affects catecholamine
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Octopamine-d4 hydrochloride | 1219803-62-9 | 98.3% | 5 MG
Octopamine-d4 (hydrochloride) is the deuterium labeled Octopamine hydrochloride. Octopamine ((±)-p-Octopamine) hydrochloride, a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. Octopamine hydrochloride can stimulate alpha2-adrenoceptors (ARs) in Chinese hamster ovary cells transfected with human alpha2-ARs. It has been shown to increase glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis and the portal perfusion pressure.
- Molecular formula: C8H9D3CINO2
- Molecular weight: 192.66
- Target: Adrenergic receptor; endogenous metabolite
- Pathway: GPCR/G protein; neuronal signaling; metabolic enzyme/protease
- Storage: 4°C, sealed storage, away from moisture. In solvent: -80°C for 6 months; -20°C for 1 month (sealed storage, away from moisture).
- Solubility (in vitro): DMSO: ≥ 100 mg/mL (519.05 mM); H2O: ≥ 50 mg/mL (259.52 mM)
Medchemexpress LLC Pirfenidone-d5 | 1020719-62-3 | 98.9% | 5 MG
Pirfenidone-d5 (AMR69-d5) is a deuterium labeled Pirfenidone. It acts as an antifibrotic agent by attenuating CCL2 and CCL12 production in fibrocyte cells. This compound also exhibits a growth-inhibitory effect, reducing TGF-β2 protein levels in human glioma cell lines, and possesses anti-inflammatory activities. It is intended for research use only and can serve as a tracer or an internal standard for quantitative analysis.
- Used as a tracer for quantitative analysis
- Functions as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Attenuates CCL2 and CCL12 production in fibrocyte cells
- Exhibits a growth-inhibitory effect
- Reduces TGF-β2 protein levels in human glioma cell lines
- Possesses anti-inflammatory activities