Isotopically Labeled Compounds
Medchemexpress LLC Darolutamide-d4 | 2484757-20-0 | 98.6% | 402.87 | 500 UG
Darolutamide-d4 is a deuterium-labeled version of Darolutamide. It is an orally active, competitive androgen receptor (AR) antagonist that inhibits testosterone-induced AR nuclear translocation and transcriptional activation. This compound selectively affects AR-positive cells by inhibiting AR-dependent signaling pathways, and its active metabolite maintains full antagonistic activity against AR mutants. It can be used for research on prostate cancer, including androgen receptor-dependent prostate cancer.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Apexbio Technology LLC Sphingosine-1-phosphate 26993-30-6 25mg
Sphingosine-1-phosphate (CAS 26993-30-6) is an endogenous signaling lipid functioning as a second messenger and ligand for the G-protein-coupled receptor S1PR1 (also called EDG1) It modulates diverse cellular processes including proliferation survival migration and vascular morphogenesis via activation of downstream pathways such as ERK-1/2 kinase and Gi protein-mediated signaling In cell-based assays S1P exhibits high-affinity binding (Kd 8 1 nM) to S1PR1 and induces calcium mobilization with an EC50 of approximately 2 nM Due to its roles in platelet function cell survival and vascular biology S1P is widely investigated in cell signaling research and therapeutic development
Medchemexpress LLC Acetylcholine-d4 chloride | 344298-94-8 | 99.2% | 1 MG
Acetylcholine-d4 (chloride) is the deuterium labeled Acetylcholine chloride. Acetylcholine chloride (ACh chloride), a neurotransmitter, is a potent and BBB-permeable cholinergic agonist. It modulates the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs) and inhibits p53 mutant peptide aggregation in vitro. Stable heavy isotopes have been incorporated into drug molecules for quantitation during drug development, and deuteration has the potential to affect pharmacokinetic and metabolic profiles.
- Used as a tracer
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Modulates dopaminergic neuron activity
- Inhibits p53 mutant peptide aggregation in vitro
- Deuterium labeled for potential pharmacokinetic and metabolic profile effects
Medchemexpress LLC Acetylcholine-d9 (chloride) | 344298-95-9 | 99.0% | 5 MG
Acetylcholine-d9 (chloride) is a deuterium-labeled Acetylcholine chloride, a neurotransmitter and a potent, BBB-permeable cholinergic agonist. It modulates dopaminergic neuron activity by stimulating nicotinic acetylcholine receptors (nAChRs) and inhibits p53 mutant peptide aggregation in vitro.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Doxapram-d8 | 309-29-5 | 99.5% | 1 MG
Doxapram-d8 is deuterated labeled Doxapram, which is a respiratory stimulant. It increases breathing rate and depth by acting on the brain's respiratory centers and peripheral chemoreceptors. Doxapram inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50s of 410 nM, 37 μM, 9 μM, respectively.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Sulfamethoxazole-d4 | 1020719-86-1 | 99.3% | 1 ML
Sulfamethoxazole-d4 is a deuterium-labeled sulfonamide antibiotic, also known as Ro 4-2130-d4. It demonstrates widespread antibacterial activity by inhibiting bacterial folate metabolism, specifically by competing with 4-Aminobenzoic acid (PABA) to act on dihydropteroate synthetase and dihydropteroate reductase. This product is intended for research use only.
- Deuterium labeled analog
- Sulfonamide antibiotic with widespread antibacterial activity
- Inhibits bacterial folate metabolism
- Suitable for studying urinary tract infections (UTIs), prostatitis, and bronchitis
- Supplied as a 10 mM solution in DMSO
Medchemexpress LLC Flubendazole-d3 | 1173021-08-3 | 96.00% | 1 MG
Flubendazole-d3 is a deuterium-labeled version of Flubendazole, a safe and effective anthelmintic agent used in humans, rodents, and ruminants. It demonstrates anticancer activities by inhibiting microtubule function, inducing p53-mediated apoptosis, and arresting the G2/M cell cycle. Deuterium substitution in drug molecules can impact their pharmacokinetic and metabolic profiles.
- Deuterium labeled version of Flubendazole
- Safe and effective anthelmintic agent
- Exhibits anticancer activities via microtubule inhibition
- Induces p53-mediated apoptosis
- Arrests G2/M cell cycle
- Can be used as a tracer
- Serves as an internal standard for quantitative analysis (e.g., NMR, GC-MS, LC-MS)
Apexbio Technology LLC MK-2206 dihydrochloride 1032350-13-2 10mM (in 1mL DMSO)
MK-2206 dihydrochloride (CAS 1032350-13-2) is a selective inhibitor targeting Akt isoforms Akt1 Akt2 and Akt3 This compound acts by suppressing phosphorylation of Akt at critical residues Thr308 and Ser473 thus effectively inhibiting the downstream Akt signaling pathway By disrupting Akt-mediated signaling MK-2206 promotes apoptosis in cancer cells and enhances susceptibility to chemotherapy agents In research contexts MK-2206 has demonstrated enhanced tumor-cell sensitivity when combined with etoposide or rapamycin highlighting its utility in cancer biology studies and therapy evaluations
Cayman Chemical TelaprevIr-d4 250ug
An internal standard for the quantification of telaprevir by GC- or LC-MS
Cayman Chemical 8-Iso ProstaglndIn F2a-d4 50ug
An internal standard for the quantification of 8-iso PGF2α by GC- or LC-MS
Cayman Chemical ProstaglndIn F2a-d4 100ug
An internal standard for the quantification of PGF2α by GC- or LC-MS.
Medchemexpress LLC 2-Oxazolidinone, 5-[(3,5-dimethylphenoxy-2,4,6-d3)methyl]- | 1192812-66-0 | 98.0% | 5 MG
Metaxalone-d3 is a deuterium-labeled derivative of Metaxalone, an FDA-approved muscle relaxant. It primarily acts on the central nervous system by inhibiting polysynaptic reflex arcs. It also inhibits MAO-A, offering anti-inflammatory and antioxidant effects. Stable heavy isotopes have been incorporated into drug molecules for tracing and can influence drug pharmacokinetics and metabolic profiles.
- Deuterium labeled Metaxalone
- FDA-approved muscle relaxant
- Inhibits polysynaptic reflex arcs
- Inhibits MAO-A, providing anti-inflammatory and antioxidant effects
- Isotopic enrichment of 99.10%
Medchemexpress LLC Mebeverine acid-d5, hydrochloride | 475203-77-1 | 99.0% | 1 MG
Mebeverine acid-d5 hydrochloride is a deuterium labeled form of Mebeverine acid hydrochloride, a secondary metabolite of the intestinal antispasmodic agent Mebeverine. It is formed by the body's hydrolysis of Mebeverine, acting as a key circulating metabolite and an important marker for oral Mebeverine. This compound is intended for research use only, leveraging stable heavy isotopes for quantitation in drug development.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Benzyl alcohol-d1 (Benzenemethanol-d1) | 14915-25-4 | 95.7% | 100 MG
Benzyl alcohol-d1 is a deuterium-labeled benzyl alcohol. It serves as a tracer and internal standard for quantitative analysis using techniques such as NMR, GC-MS, or LC-MS. Deuteration has the potential to influence the pharmacokinetic and metabolic profiles of drugs.
- Used as a tracer
- Functions as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Deuteration may affect the pharmacokinetic and metabolic profiles of drugs
- Stable heavy isotopes like deuterium are incorporated into drug molecules for quantitation during drug development
Medchemexpress LLC Spironolactone-d7 | 99.96% | 100 UG
Spironolactone-d7 is the deuterium labeled version of Spironolactone, an orally active aldosterone mineralocorticoid receptor antagonist with an IC50 of 24 nM and a potent antagonist of androgen receptor with an IC50 of 77 nM. It is known to promote autophagy in podocytes and is commonly used as a tracer or an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuterium labeled compound for accurate tracing
- Can be used as an internal standard in quantitative analysis
- High purity (99.96%) for reliable results
- Supports research in drug development and metabolism
- Applicable in studies related to cancer and endocrine diseases