Isotopically Labeled Compounds
Cayman Chemical 14 15Leukotriene D4
A unique LT with weak contractile activity on both guinea pig ileum and pulmonary parenchyma compared to 5-LO-derived LTs; increases vascular permeability of human endothelial cell monolayers with similar potency to that of 5-LO-derived LTs
Medchemexpress LLC 16:0-18:1 PA-d31 sodium | 474943-59-4 | 99.0% | 728.10 | 1 MG
16:0-18:1 PA-d31 (sodium) is deuterium labeled 16:0-18:1 PA (sodium). It is for research use only and not sold to patients. Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuteration has potential to affect the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC L-Lysine-d4 hydrochloride | 284664-96-6 | 186.67 | 5 MG
L-Lysine-d4 hydrochloride | 284664-96-6 | 186.67 | 5 MG
Medchemexpress LLC L-Glutamine-13C5 | 184161-19-1 | 151.11 | 50 MG
L-Glutamine-13C5 is the 13C-labeled L-Glutamine, a non-essential amino acid abundantly present throughout the body and involved in many metabolic processes. It provides a source of carbons for oxidation in some cells.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Hypericin-d10 | 514.50 | 1 MG
Hypericin-d10 is the deuterium-labeled Hypericin. Hypericin is a photosensitive antiviral with anticancer and antidepressant properties, derived from *Hypericum perforatum*. It can inhibit tyrosine kinases with an IC50 of 7.5 μM.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Cayman Chemical AxItInIb-13C-d3 1mg
An internal standard for the quantification of axitinib by GC- or LC-MS
Cayman Chemical DofetIlIde-d4 1mg
An internal standard for the quantification of dofetilide by GC- or LC-MS
Cayman Chemical AmlodIpIn-d4maleate 5mg
An internal standard for the quantification of amlodipine by GC- or LC-MS
Cayman Chemical FngolImod-d4 500ug
An internal standard for the quantification of fingolimod by GC- or LC-MS
Medchemexpress LLC L-Lysine-13C6,15N2 hydrochloride | 1200447-00-2 | 190.59 | 50 MG
L-Lysine-13C6,15N2 (hydrochloride) is a stable isotope-labeled version of L-lysine hydrochloride, an essential amino acid. It is intended for research use only and not for patient consumption. The unlabeled L-lysine hydrochloride has various benefits, including aiding in the treatment of herpes, improving calcium absorption, reducing illnesses related to diabetes, and enhancing gut health.
- Can be used as a tracer.
- Can serve as an internal standard for quantitative analysis through techniques like NMR, GC-MS, or LC-MS.
- Incorporates stable heavy isotopes of carbon-13 and nitrogen-15.
- Potential to affect pharmacokinetic and metabolic profiles in drug development.
Medchemexpress LLC Deoxycholic acid | 83-44-3 | 392.57 | 10 G
Deoxycholic acid (cholanoic acid), a bile acid, is a by-product of intestinal metabolism that activates the G protein-coupled bile acid receptor TGR5. It induces the production of gastric cancer cell line MGC803 resistant to acidified bile acids and enhances their survival and proliferation activity under bile acid stress. DCA-induced resistant cells show altered morphology, significantly elevated telomerase activity, better cell viability, and reduced apoptosis compared to normal MGC803 cells.
- Activates the G protein-coupled bile acid receptor TGR5.
- Induces resistance in gastric cancer cell lines to acidified bile acids.
- Enhances survival and proliferation activity of gastric cancer cells under bile acid stress.
- Increases telomerase activity in resistant cells.
- Improves cell viability and reduces apoptosis in resistant cells.
Medchemexpress LLC L-Glutamine-13C5,15N2 | 285978-14-5 | 153.09 | 5 MG
L-Glutamine-13C5,15N2 is a 13C- and 15N-labeled form of L-Glutamine, a non-essential amino acid crucial for many metabolic processes. This compound provides a source of carbons for oxidation in various cells and appears as a white to off-white solid. It is intended for research use only.
- Used as a tracer
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
