Isotopically Labeled Compounds
Medchemexpress LLC Velnacrine-d4 hydrochloride | 1246816-08-9 | 98.6% | 1 MG
Velnacrine-d4 hydrochloride is a deuterium-labeled form of Velnacrine, intended exclusively for research purposes. This compound is not sold to patients. The incorporation of stable heavy isotopes, such as deuterium, into drug molecules serves as tracers for quantitative analysis in drug development, with deuteration potentially affecting pharmacokinetic and metabolic profiles.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by nuclear magnetic resonance (NMR), gas chromatography-mass spectrometry (GC-MS), or liquid chromatography-mass spectrometry (LC-MS)
Medchemexpress LLC Thiabendazole-d4 (2-(4-thiazolyl)benzimidazole-d4) | 1190007-20-5 | 98.9% | 5 MG
Thiabendazole-d4 is a deuterated form of Thiabendazole, an antiseptic, antifungal, and antiparasitic agent intended for research use only. This compound, appearing as a white to off-white solid, can be used as a tracer and an internal standard for quantitative analysis. Deuteration can affect the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Dopamine-13C,15N hydrochloride | 369656-74-6 | 99.0% | 5 MG
Dopamine-13C,15N (hydrochloride) is the 13C and 15N labeled Dopamine hydrochloride. It is intended for research use only and not for sale to patients. This compound can be used as a tracer and as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS. Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, primarily as tracers for quantitation during the drug development process. Deuteration has also garnered attention due to its potential impact on the pharmacokinetic and metabolic profiles of drugs.
- Dopamine-13C,15N (hydrochloride) is the 13C and 15N labeled Dopamine hydrochloride.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Orlistat-d3 | 1356930-46-5 | 1 MG
Orlistat-d3 is a deuterated form of Orlistat, an irreversible inhibitor of pancreatic and gastric lipases and fatty acid synthase (FASN). It is employed in long-term research for obesity due to its anti-atherosclerotic effects, and can also be used as a tracer and internal standard for quantitative analysis.
- Used as a tracer in drug development.
- Functions as an internal standard for quantitative analysis, including by NMR, GC-MS, or LC-MS.
- Deuteration can influence pharmacokinetic and metabolic profiles of drugs.
- Demonstrates anti-atherosclerotic effects.
- Shown to downregulate a repair protein in specific human cell lines during in vitro studies.
- Exhibits improved lipid profiles and increased antioxidant enzymes in in vivo studies.
Sigma Aldrich Fine Chemicals Biosciences Lauric-d23 acid >=98 atom % D, >=98% (CP) | 59154-43-7 | MFCD00144567 | 1G
Lauric-d23 acid >=98 atom % D, >=98% (CP) | Purity: >=98% (CP) | Mol Wt: 223.46 | 59154-43-7 | MFCD00144567 | 1G
Medchemexpress LLC Mequinol-d4 | 126840-02-6 | 98.9% | 128.16 | 5 MG
Mequinol-d4 is a laboratory chemical primarily used for research. It is presented as a solid and is stable under recommended storage conditions. This substance is not classified as hazardous and is intended for experienced personnel in appropriately equipped facilities.
- Used as a laboratory chemical
- Not classified as a hazardous substance
- Stable under recommended storage conditions
- Available as a solid
- Recommended storage for powder: -20°C for 3 years
- Recommended storage in solvent: -80°C for 6 months, -20°C for 1 month
- High purity (98.9%)
Medchemexpress LLC Ketorolac-d5 | 1215767-66-0 | 98.8% | 5 MG
Ketorolac-d5 is a deuterium labeled Ketorolac. Ketorolac is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Store powder at -20°C for 3 years; 4°C for 2 years.
- Store in solvent and stock solution at -80°C for 6 months; -20°C for 1 month.
Medchemexpress LLC D-Glucose-13C-3 | 105931-74-6 | 99.7% | 50 MG
D-Glucose-13C-3 | 105931-74-6 | 99.7% | 50 MG
Medchemexpress LLC Dopamine-13C hydrochloride | 335081-04-4 | 99.7% | 1 MG
Dopamine-13C hydrochloride | 335081-04-4 | 99.7% | 1 MG
Medchemexpress LLC Sulfamethizole-d4 | 2470130-12-0 | >=99% | 5 MG
Sulfamethizole-d4 | 2470130-12-0 | >=99% | 5 MG
Medchemexpress LLC Vardenafil-d5 (hydrochloride) | 1189685-70-8 | MFCD00222079 | 98.7% | 5 MG
Vardenafil-d5 (Vardenafil-d5 hydrochloride) is a deuterated form of Vardenafil, a potent and selective cGMP-specific phosphodiesterase type 5 (PDE5) inhibitor. It is labeled with 5 deuterium atoms at the ethoxyl group of Vardenafil. Vardenafil is known for its ability to increase cGMP levels, leading to smooth muscle relaxation and vasodilation. Vardenafil-d5 is intended for research applications such as bioanalysis, especially in pharmacokinetic studies, drug metabolism research, and for use as an internal standard.
- Deuterated internal standard
- Suitable for pharmacokinetic studies
- Useful in drug metabolism research
- Increases cGMP levels
- Leads to smooth muscle relaxation and vasodilation
- Potent and selective cGMP-specific phosphodiesterase type 5 (PDE5) inhibitor
Cayman Chemical PItavastatIn lacton-d4 1mg
An internal standard for the quantification of pitavastatin lactone by GC- or LC-MS
Medchemexpress LLC Lidocaine-d10 | 851528-09-1 | 99.58% | 1 MG
Lidocaine-d10 is deuterium-labeled Lidocaine, an amide derivative that inhibits sodium channels. It decreases the growth, migration, and invasion of gastric carcinoma cells by up-regulating miR-145 expression and inactivating MEK/ERK and NF-κB signaling pathways. It has potential for the research of ventricular arrhythmia.
Medchemexpress LLC Enoxacin-d8 hydrochloride | 2930288-95-0 | 99.98% | 1 MG
Enoxacin-d8 (hydrochloride) is a deuterium-labeled Enoxacin. Enoxacin is a fluoroquinolone that interferes with DNA replication and inhibits bacterial DNA gyrase and topoisomerase IV. It also acts as a miRNA processing activator, enhancing siRNA-mediated mRNA degradation and promoting the biogenesis of endogenous miRNAs. This compound exhibits potent activity against both gram-positive and gram-negative bacteria and is identified as a cancer-specific growth inhibitor by enhancing TAR RNA-binding protein 2 (TRBP)-mediated microRNA processing. It is for research use only.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS