Isotopically Labeled Compounds
Medchemexpress LLC DL-Xylose | 25990-60-7 | MFCD00198055 | 98.0% | 1 ML
DL-Xylose is an organic synthesis intermediate, appearing as a white to off-white solid. This compound is intended for research applications only.
- Organic synthesis intermediate
- For research use only
- Soluble in water and PBS
Medchemexpress LLC Vardenafil-d5 (hydrochloride) | 1189685-70-8 | MFCD00222079 | 98.7% | 5 MG
Vardenafil-d5 (Vardenafil-d5 hydrochloride) is a deuterated form of Vardenafil, a potent and selective cGMP-specific phosphodiesterase type 5 (PDE5) inhibitor. It is labeled with 5 deuterium atoms at the ethoxyl group of Vardenafil. Vardenafil is known for its ability to increase cGMP levels, leading to smooth muscle relaxation and vasodilation. Vardenafil-d5 is intended for research applications such as bioanalysis, especially in pharmacokinetic studies, drug metabolism research, and for use as an internal standard.
- Deuterated internal standard
- Suitable for pharmacokinetic studies
- Useful in drug metabolism research
- Increases cGMP levels
- Leads to smooth muscle relaxation and vasodilation
- Potent and selective cGMP-specific phosphodiesterase type 5 (PDE5) inhibitor
Medchemexpress LLC Carbaryl-d7 | 362049-56-7 | 99.0% | 1 MG
Carbaryl-d7 is a deuterium-labeled form of Carbaryl, an acetylcholinesterase inhibitor that prevents the breakdown of acetylcholine in the synaptic cleft, leading to its accumulation and causing neurotoxicity. It can also function as an insecticide.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Flecainide-d4 (acetate) | 1276197-21-7 | 99.0% | 478.42 | 1 MG
Flecainide-d4 (acetate) is the deuterium labeled Flecainide acetate, a class 1C antiarrhythmic agent used for managing supraventricular arrhythmia. It functions by blocking the Nav1.5 sodium channel in the heart, leading to a prolongation of the cardiac action potential.
- Used as a tracer
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC 1-Naphthyl-d7 N-methylcarbamate | 362049-56-7 | 99% | 5 MG
Carbaryl-d7 is a deuterium-labeled version of Carbaryl, an acetylcholinesterase inhibitor. It functions by preventing the breakdown of acetylcholine in the synaptic cleft, leading to acetylcholine accumulation and neurotoxicity. This compound is primarily used as an insecticide.
- Can be used as a tracer.
- Functions as an internal standard for quantitative analysis using NMR, GC-MS, or LC-MS.
- Incorporates stable heavy isotopes for pharmacokinetic and metabolic studies.
Medchemexpress LLC Sorbic acid-13C2 | 114.11 | C4(13C)2H8O2 | 1mg
Sorbic acid-13C2 is the 13C-labeled Sorbic acid (HY-N0626) Sorbic acid is an effective safe and non-toxic food preservative It can effectively inhibit most molds yeasts and certain bacteria Sorbic acid is orally active and can enhance the growth performance of economically important animals (Duroc Landrace Yorkshire piglets) by activating the insulin-like growth factor system (IGF) and it can also lead to lipid accumulation by disrupting lipid clearance pathways[1][2][3][4]
Medchemexpress LLC L-Asparagine-15N2 hydrate | 287484-32-6 | 152.12 | 50 MG
L-Asparagine-15N2 monohydrate is the 15N-labeled L-Asparagine monohydrate. It is an essential amino acid for leukemic cells and a substrate for L-Asparaginase, a potent anti-leukemic enzyme. L-Asparaginase promotes asparagine and glutamine depletion, inhibiting protein biosynthesis in lymphoblasts, leading to inhibition of RNA and DNA synthesis and subsequent apoptosis. This compound can be used as a tracer or as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Used as a tracer
- Used as an internal standard for quantitative analysis
- Suitable for NMR, GC-MS, or LC-MS applications
Medchemexpress LLC Tacrolimus-13C,d2 | 1356841-89-8 | 98.4% | 807.02 | 1 MG
Tacrolimus-13C,d2 is a 13C-labeled and deuterium-labeled form of Tacrolimus, a macrocyclic lactone. It inhibits calcineurin phosphatase by forming a complex with FKBP, which leads to immunosuppressive properties by inhibiting T-lymphocyte signal transduction and IL-2 transcription. This compound can be used as a tracer and an internal standard for quantitative analysis.
- Labeled with 13C and deuterium
- Inhibits calcineurin phosphatase
- Possesses immunosuppressive properties
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Chlorhexidine-d8 dihydrochloride | 2012598-75-1 | 95.7% | 1 MG
Chlorhexidine-d8 dihydrochloride is a deuterium labeled form of Chlorhexidine dihydrochloride, an orally active cationic antimicrobial agent. It targets microbial cell membranes, binding to phospholipids non-specifically to destroy membrane structure and induce leakage of cell contents. It exhibits broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria by interfering with membrane permeability, causing protein precipitation, and disrupting energy metabolism. This leads to rapid inhibition of microbial growth and induction of cell death.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC L-glutamine-15N-1 (L-glutamic acid 5-amide-15N-1) | 59681-32-2 | MFCD00084214 | 98.0% | 147.14 g/mol | C5H10N15NO3 | 10 MG
L-Glutamine-15N-1 is the 15N-labeled form of the amino acid L-glutamine used as a stable isotope tracer and analytical standard for metabolic labeling and mass spectrometry applications.
- Isotope-labeled L-glutamine for tracer and analytical studies.
- Purity ≥98.0% as stated by the manufacturer.
- Available as small solid packages (for example 10 mg) and as a 10 mM aqueous solution.
- Soluble in water (25 mg/mL; ultrasonic may be needed) and in PBS for working solutions.
- White to off-white solid; powder storage recommended at -20°C for long-term stability.
Medchemexpress LLC DC-LC3in-D5 | 2868312-73-4 | 98.6% | C19H22Cl2N2O3 | 10 MM 1 ML
DC-LC3in-D5 is an autophagy inhibitor that functions by attenuating LC3B lipidation. It binds with LC3B and disrupts the LC3B-LBP2 interaction with an IC50 of 200 nM. This compound may be useful in anti-HCV or combination cancer research through its autophagy-inhibiting properties.
- Attenuates LC3B lipidation
- Disrupts LC3B-LBP2 interaction
- Demonstrates high selectivity to LC3A/B in proteome
- Exhibits potent covalent reactivity and selectivity to LC3A/B in HeLa cells
- Inhibits autophagic vesicle formation
- Leads to accumulation of p62
Medchemexpress LLC L-Asparagine-15N2 monohydrate | 287484-32-6 | MFCD01073515 | 152.12 | 25 MG
L-Asparagine-15N2 monohydrate is the 15N-labeled L-Asparagine monohydrate, an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is an anti-leukemic enzyme that promotes asparagine and glutamine depletion, inhibiting protein biosynthesis in lymphoblasts. Its removal from plasma by L-Asparaginase leads to inhibition of RNA and DNA synthesis and subsequent apoptosis, selectively inhibiting the growth of cancer cells with low asparagine synthetase expression. This compound can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC L-Asparagine-15N2 monohydrate | 287484-32-6 | 152.12 | 5 MG
L-Asparagine-15N2 monohydrate is the 15N-labeled version of L-Asparagine monohydrate. L-Asparagine monohydrate is an essential amino acid for leukemic cells and serves as a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that depletes asparagine (Asn) and glutamine (Gln), thereby inhibiting protein biosynthesis in lymphoblasts. The removal of L-asparagine from plasma by L-Asparaginase leads to inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase demonstrates cell-killing ability both in vitro and in vivo, selectively inhibiting the growth of cancer cells that have low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can also be utilized as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia.
- This compound can be used as a tracer.
- This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.