Cell Function Reagents and Kits
![Medchemexpress LLC 5-chloro-N-[2-(4-hydroxysulfamoyl-phenyl)-ethyl]-2-methoxy-benzamide | 2112809-98-8 | 98.4% | 384.83 g/mol | C16H17ClN2O5S | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000226690.png-250.jpg)
Medchemexpress LLC 5-chloro-N-[2-(4-hydroxysulfamoyl-phenyl)-ethyl]-2-methoxy-benzamide | 2112809-98-8 | 98.4% | 384.83 g/mol | C16H17ClN2O5S | 50 MG
JC-171 is a selective NLRP3 inflammasome inhibitor that reduces LPS/ATP-induced interleukin-1β (IL-1β) release from J774A.1 macrophages with an IC50 of 8.45 μM. It is supplied as a solid and as a DMSO solution for research use, with reported high purity and defined storage recommendations.
- Selective NLRP3 inflammasome inhibition in cell-based assays.
- Activity: IC50 8.45 μM for inhibition of IL-1β release.
- High reported purity: 98.41%.
- Molecular weight 384.83 g/mol; formula C16H17ClN2O5S.
- Available as solid quantities and as a 10 mM solution in DMSO.
- Storage recommendations provided for powder and in-solution stability.
Cayman Chemical XTT Cell Proliferation Assay
Cayman’s XTT Cell Proliferation Assay provides an EAsy to use tool for studying induction and inhibition of cell proliferation in any in vitro model. The assay is based on the extracellular reduction of XTT by NADH produced in the mitochondria via trans-plasma membrane electron transport and an electron mediator. Reduction of XTT produces a water-soluble formazan that dissolves directly into the culture medium, eliminating the need for an additional solubilization step. This kit will allow investigators to screen drug candidates involved in cell cycle regulation.
Abcam Mitochondrial Staining Kit - NIR Fluorescence - Cytopainter.
Mitochondrial Staining Kit - NIR Fluorescence - Cytopainter.
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC HY-15621A 5mg Medchemexpress, DMA (trihydrochloride) CAS:2095832-33-8 Purity:>98%
Medchemexpress, HY-15621A 5mg DMA (trihydrochloride) CAS:2095832-33-8 DMA trihydrochloride is a fluorescent compound (λex=340 nm, λem=478 nm). Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Biotium Fura-2, AM Ester, 1mM In Anhydrous DMSO
Fura-2, AM ester is an intracellular fluorescent calcium indicator, and the preferred dye for ratiometric imaging microscopy. The membrane-permeant AM ester can be loaded into cells via incubation, but due to limited water solubility, a mild detergent Pluronic F-127 is often used to facilitate cell loading. Fura-2, AM ester itself does not bind Ca2, but intracellular esterases readily hydrolyze it to Fura-2. Upon calcium binding, the excitation maximum of Fura-2 undergoes a blue-shift from 363 nm (no Ca2) to 335 nm (high Ca2) while the emission maximum is relatively unchanged. Measure by flow cytometry, fluorescence microscopy, or certain fluoresence microplate readers. Properties: Light yellow solid soluble in DMSO; Store at -20°C, protect from light, especially in solution; Kd: 145 nM (22°C, pH 7.2 buffer); Ex/Em = 363/512 nm, e = 27,000 M-1cm-1 (no Ca2); Ex/Em 335/505 nm, e = 35,000 M-1cm-1 (high Ca2); C44H47N3O24; MW: 1001.9; [108964-32-5].
Biotium Sulforhodamine 101
Sulforhodamine 101 has a longer absorption wavelength than does sulforhodamine B. Like sulforhodamine B and G, in addition to their potential use in cancer drug screening, these fluorescent dyes have been primarily used as polar tracers for the studies of neuronal cell morphology and cell-cell communication. Properties: Ex/Em = 586/605 nm; Red solid soluble in water; Store at room temperature; C31H30N2O7S2; MW: 607; [60311-02-6]
Apexbio Technology LLC CFDA-SE(Synonyms: CFSE, Carboxyfluorescein succinimidyl ester, 5-(and-6)-Carboxyfluorescein diacetate succinimidyl ester), 10mg, CAS: 150347-59-4.
CFDA-SE (Carboxyfluorescein diacetate succinimidyl ester CAS 150347-59-4) is a membrane-permeant fluorescent dye commonly utilized for labeling viable cells and monitoring cellular proliferation Upon entering cells intracellular esterases hydrolyze CFDA-SE into carboxyfluorescein succinimidyl ester (CFSE) which becomes fluorescent (excitation 494 nm emission 521 nm) binds covalently to intracellular amino groups and is thereafter trapped within the cell cytoplasm Each cell division results in halving fluorescence intensity enabling accurate quantification of successive proliferation events via flow cytometry CFDA-SE labeling methodology has extensive applications in assessing lymphocyte fibroblast NK cell and bacterial proliferation both in vitro and in vivo
Medchemexpress LLC JC-1 | 3520-43-2 | MFCD00188475 | 2 mg
JC-1 | Purity: 99.46% | Mol Wt: 652.23 | 3520-43-2 | MFCD00188475 | 2 mg
Cayman Chemical XTT Cell Proliferation Assay
Cayman’s XTT Cell Proliferation Assay provides an EAsy to use tool for studying induction and inhibition of cell proliferation in any in vitro model. The assay is based on the extracellular reduction of XTT by NADH produced in the mitochondria via trans-plasma membrane electron transport and an electron mediator. Reduction of XTT produces a water-soluble formazan that dissolves directly into the culture medium, eliminating the need for an additional solubilization step. This kit will allow investigators to screen drug candidates involved in cell cycle regulation.
Sigma Aldrich Fine Chemicals Biosciences Resorufin benzyl ether CYP450 substrate | 87687-02-3 | MFCD00171613 | 10MG
Resorufin benzyl ether CYP450 substrate | Purity: >=98% (TLC) | Mol Wt: 303.31 | 87687-02-3 | MFCD00171613 | 10MG
Apexbio Technology LLC CFDA SE Cell Tracer Kit,1 kit
The CFDA SE (carboxyfluorescein diacetate succinimidyl ester) Cell Tracer Kit is usually used in fluorescence analyses as a long-term tracer of cells. The Kit can be used for in vitro and in vivo labeling of cells to determine whether or not a cell is proliferating, especially.CFDA SE is a cell-permeable dye, which could bind covalently to all free amines on the surface and inside of cells. It shows little cytotoxicity, with minimal observed effect on the proliferative ability or biology of cells. The intense fluorescent staining provided by CFDA SE which distinguish labeled cells from auto-fluorescence can enable the visualization even after several days post stain, making it an ideal stain for cell tracing studies. Other sizes are also available. Please inqury us for quote.
Aat Bioquest Fura Red AM CAS 149732-62-7 (1 mg)
Fura Red is a visible light-excitable fura-2 analog that offers unique possibilities for ratiometric measurement of calcium ion in single cells by microphotometry imaging or flow cytometry when used with single excitation green-fluorescent calcium indicators. This catalog is for 1 mg.
Medchemexpress LLC HY-D0989 1mg Medchemexpress, Rhod-2 AM CAS:145037-81-6 Purity:>98%
Medchemexpress, HY-D0989 1mg Rhod-2 AM CAS:145037-81-6 Rhod-2 AM is a fluorescent, mitochondrial probe (λex=552 nm, λem=581 nm). Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Lonza Walkersville ToxiLight Non-Destructive Cytotoxicity BioAssay Kit, 1000 Test
The ToxiLight BioAssay Kit is a bioluminescent, non-destructive cytolysis assay kit designed to measure the release of the enzyme, adenylate kinase (AK), from damaged cells. AK is a robust protein present in all eukaryotic cells, which is released into the culture medium when cells die. The enzyme actively phosphorylates ADP to form ATP and the resultant ATP is then measured using the bioluminescent firefly luciferase reaction. As the level of cytolysis increases, the amount of AK in the supernatant also increases, which results in emission of higher light intensity by the ToxiLight reagent. Because the ToxiLight BioAssay Kit exploits the fact that AK is released from cells when they die, there is no need for cell lysis (unlike many other cytotoxicity assays). Repeated samples of supernatant can therefore be taken over time without disrupting the cells themselves. This allows for kinetic analysis of cell death.
Medchemexpress LLC MRS2500 tetraammonium | 630103-23-0 | 99.9% | 629.28 | 1 ML
MRS2500 tetraammonium is a potent, selective, and stable antagonist of the P2Y1 receptor (Ki=0.78 nM for recombinant human P2Y1 receptor). It inhibits the ADP-induced aggregation of human platelets with an IC50 value of 0.95 nM, demonstrating antithrombotic activity.
- Potent, selective, and stable antagonist of the P2Y1 receptor.
- Inhibits ADP-induced aggregation of human platelets with an IC50 of 0.95 nM.
- Exhibits antithrombotic activity.
- Decreases acute systemic thromboembolism through selective inhibition of the P2Y1 receptor.
- Showed strong antithrombotic efficacy in preventing arterial thrombosis in the monkey ECAT model.