Signal Transduction Reagents and Kits

Alfa Aesar™ Tacrolimus, ≥99%

Interacts with the immunophilins cyclophilin and FKBP-12

Promega™ Kinase Selectivity Profiling System: General Panel + ADP-Glo™ Assay

Offer kinases grouped either in single kinase family strips or as general panel of kinases representative of human kinome for broad kinase profile

BD Phosflow™ Violet Fluorescent Cell Barcoding Kit

Provides reagents for successfully barcoding T cell subsets from human whole blood samples for studying phosphorylated protein induction in MAP Kinase and JAK/STAT signaling pathways

Promega™ ADP-Glo™ Kinase Assay

One assay for all your kinase screening needs. The assay is well suited for measuring the effects of chemical compounds on the activity of many purified kinases, making it ideal for primary screening as well as kinase selectivity profiling.

Promega CDK2/CyclinE1 Kinase Enzyme System, 10microg

Recombinant full-length human CDK2 and CyclinE1 were co-expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag on both proteins. CDK2 is a member of the Cyclin-Dependent Kinase family that is ubiquitously expressed.

Promega™ ADP-Glo™ Kinase Assay + DNA-PK Kinase Enzyme System

For measuring effects chemical compounds have on activity of a broad range of purified kinases, making it ideal for both primary screening as well as kinase selectivity profiling

Promega™ ADP-Glo™ Kinase Assay + ULK1 Kinase Enzyme System

For measuring effects chemical compounds have on activity of broad range of purified kinases, making it ideal for both primary screening as well as kinase selectivity profiling

Alfa Aesar™ Telmisartan, 99%

An angiotensin II receptor antagonist

Alfa Aesar™ Sulindac Sulfide

Active metabolite of sulindac; inhibits cyclooxygenase-1

Alfa Aesar™ N-Acetyl-Arg-Glu-Lys-Arg-7-amino-4-(trifluoromethyl)coumarin

A fluorogenic substrate suitable for the assay of furin

Alfa Aesar™ U0126, ≥99%

Selective inhibitor of mitogen-activated protein kinases MEK-1 and MEK-2

Alfa Aesar™ SB 203580, 98%

Highly specific new inhibitor of p38 kinase and MAP Kinase homologues

Alfa Aesar™ Ionomycin, 98%

Highly selective and potent calcium ionophore

Promega™ Protein Kinase C Activator

An inactive analogue of and negative control for phorbol 12-myristate 13-acetate (PMA), which is also known as 12-O-tetradecanoylphorbol 13-acetate (TPA)

Alfa Aesar™ Vinblastine Sulfate, 98%

Anticancer agent; microtubule disrupter; Induces apoptosis

Alfa Aesar™ Tulobuterol

beta-2-adrenergic receptor agonist

Alfa Aesar™ Ionomycin Calcium Salt, 99%

Highly selective and potent calcium ionophore

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