3615

• Gene Symbol: HEY2
• Gene Name: hes related family bHLH transcription factor with YRPW motif 2
• Gene Aliases: CHF1, GRIDLOCK, GRL, HERP1, HESR2, HRT2, bHLHb32
• Chromosome Location: Chr.6: 125747592 - 125762243 on Build GRCh38
• UniGene ID: Hs.144287
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: HEY2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_012259.2	NP_036391.1	5	1953
	XM_017010627.1	XP_016866116.1	5	3337
	XM_017010628.1	XP_016866117.1	6	3035
	XM_017010629.1	XP_016866118.1	5	1814
GenBank mRNA	AJ249545.1	-	5	1812

More Information

Panther Classification:

Molecular Function -

basic helix-loop-helix transcription factor

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
vasculogenesis
muscular septum morphogenesis
outflow tract morphogenesis
pulmonary valve morphogenesis
tricuspid valve morphogenesis
tricuspid valve formation
endocardial cushion to mesenchymal transition involved in heart valve formation
cardiac ventricle morphogenesis
cardiac left ventricle morphogenesis
cardiac right ventricle morphogenesis
ventricular trabecula myocardium morphogenesis
transcription, DNA-templated
Notch signaling pathway
anterior/posterior axis specification
positive regulation of heart rate
negative regulation of transcription by transcription factor localization
negative regulation of gene expression
negative regulation of cardiac muscle cell apoptotic process
mesenchymal cell development
cardiac muscle hypertrophy in response to stress
ascending aorta morphogenesis
dorsal aorta morphogenesis
umbilical cord morphogenesis
cell fate commitment
regulation of auditory receptor cell differentiation
negative regulation of Notch signaling pathway
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
smooth muscle cell differentiation
ventricular cardiac muscle cell development
positive regulation of cardiac muscle cell proliferation
cardiac epithelial to mesenchymal transition
heart trabecula formation
cardiac septum morphogenesis
ventricular septum morphogenesis
atrial septum morphogenesis
negative regulation of transcription initiation from RNA polymerase II promoter
labyrinthine layer blood vessel development
arterial endothelial cell differentiation
cardiac vascular smooth muscle cell development
coronary vasculature morphogenesis
pulmonary artery morphogenesis
Notch signaling involved in heart development
protein-DNA complex assembly
cochlea development
vascular smooth muscle cell development
negative regulation of transcription regulatory region DNA binding
negative regulation of cardiac vascular smooth muscle cell differentiation
negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation
regulation of vasculogenesis

Function(s)

transcription factor activity, RNA polymerase II core promoter sequence-specific
transcription factor activity, protein binding
RNA polymerase II activating transcription factor binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
microsatellite binding
protein homodimerization activity
histone deacetylase binding
sequence-specific DNA binding
protein heterodimerization activity