Biochemical Reagents
Medchemexpress LLC Peptide YY (PYY), human | 118997-30-1 | 99.2% | 4309.75 | 1 MG
Peptide YY (PYY) is a gut hormone that regulates appetite and inhibits pancreatic secretion. It acts through Neuropeptide Y receptors and belongs to the pancreatic polypeptide family. This 36-amino acid peptide is secreted from L cells in the gastrointestinal tract and can strongly inhibit secretin-stimulated pancreatic secretion, reducing bicarbonate and fluid secretion. It is also found in blood vessels, causing vasoconstriction.
- Regulates appetite and inhibits pancreatic secretion.
- Mediates effects through Neuropeptide Y receptors.
- Composed of 36 amino acids.
- Secreted from neuroendocrine cells in the gastrointestinal tract.
- Strongly inhibits secretin-stimulated pancreatic secretion.
- Decreases pancreatic bicarbonate and fluid secretion.
- Causes vasoconstriction of the vascular tree.
- Solid, white to off-white appearance.
Medchemexpress LLC PACAP-38 (31-38), human, mouse, rat | 138764-85-9 | 98.8% | 1062.27 | 10 MG
PACAP-38 (31-38), human, mouse, rat is a fragment containing the C-terminal 31-38 fragment of PACAP (1-38), human, ovine, rat. This fragment does not bind to the PACAP receptor.
- For research use only.
- Available in various quantities.
- Solid appearance, white to off-white color.
- Sequence: Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-NH2 (YKQRVKNK-NH2).
- Shipping at room temperature in continental US.
- Storage: Sealed, away from moisture.
- Solubility in H2O: 100 mg/mL (94.14 mM; requires ultrasonic).
Enzo Life Sciences Galanin (human) (1mg). CAS: 119418-04-1
Neuropeptide widely expressed in the central and peripheral nervous systems and in the endocrine system. Has been shown to regulate numerous physiological and pathological processes through interactions with three G-protein-coupled receptors, GalR1 through GalR3. Formula: C139H210N42O43. MW: 3157.5. Purity: ≥98%. Solubility: Soluble in water, 0.1% TFA or acetic acid solution. Long Term Storage: -20°C.
Bachem a-MSH Trifluoroacetate
a-MSH Trifluoroacetate, Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2, 581-05-5, C77H109N21O19S, Mr 1664.91, 25mg. Acetyl-ACTH (1-13) amide, a-Melanotropin (human). a-Melanotropin, also known as a-melanocyte-stimulating hormone (a-MSH), is a 13-amino acid peptide originally characterized as a neuropeptide derived from the pituitary gland. a-MSH is synthesized from pro-opiomelanocortin (POMC) by the action of specific prohormone convertases and is involved in the regulation of important physiological functions including food intake, energy homeostasis, modulation of immune responses and photoprotection.
Medchemexpress LLC Tat-NR2Baa | 847829-41-8 | 96.9% | 2474.83 | 1 MG
This product is a control peptide for another peptide, though it is inactive. Its sequence is similar to the active peptide, but a double-point mutation in its COOH terminal tSXV motif renders it unable to bind to PSD-95. The active peptide is a membrane-permeant peptide that interferes with PSD-95/NMDAR binding, leading to the uncoupling of NR2B- and/or NR2A-type NMDARs from PSD-95.
- Functions as a control peptide for an active counterpart.
- Inactive, useful for comparative studies.
- Features a double-point mutation in the COOH terminal tSXV motif.
- Incapable of binding PSD-95.
- The active version of this peptide disrupts PSD-95/NMDAR binding.
- The active version uncouples NR2B- and/or NR2A-type NMDARs from PSD-95.
Bachem Biotinyl-Amylin (mouse, rat) Trifluoroacetate
Biotinyl-Amylin (mouse, rat) Trifluoroacetate, Biotinyl-Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-Arg-Ser-Ser-Asn-Asn-Leu-Gly-Pro-Val-Leu-Pro-Pro-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH2, 1678414-88-4, C177H286N54O55S3, Mr 4146.75, 1mg.
Cayman Chemical SynthetIc Salsalate 100g
An NSAID and a prodrug form of salicylic acid; inhibits PGE2 production in human whole blood stimulated with LPS (IC50 = 39.9 µM); inhibits weight gain and decreases fasting plasma glucose and insulin levels, as well as decreases plasma cholesterol and triglyceride levels in a mouse model of high-fat high-cholesterol diet-induced NASH at 1,000 mg/kg
Medchemexpress LLC TAT-14 | 1362661-34-4 | 99.7% | 3173.59 | 1 MG
TAT-14 is a 14-mer peptide that functions as an Nrf2 activator with anti-inflammatory properties. It does not affect Nrf2 mRNA expression, but instead increases Nrf2 protein levels by targeting the Nrf2 binding site on Keap1.
- Functions as an Nrf2 activator
- Has anti-inflammatory properties
- Increases Nrf2 protein levels by targeting the Nrf2 binding site on Keap1
- Soluble in H2O at 100 mg/mL (31.51 mM); requires ultrasonic
- Soluble in PBS at 50 mg/mL (15.76 mM); clear solution; requires ultrasonic
- For research use only
Bachem Urocortin (human) Trifluoroacetate
Urocortin (human) Trifluoroacetate, H-Asp-Asn-Pro-Ser-Leu-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Thr-Leu-Leu-Glu-Leu-Ala-Arg-Thr-Gln-Ser-Gln-Arg-Glu-Arg-Ala-Glu-Gln-Asn-Arg-Ile-Ile-Phe-Asp-Ser-Val-NH2, 176591-49-4, C204H337N63O64, Mr 4696.31, 0.5mg. Using a genomic library, human urocortin (UCN) has been cloned and localized to human chromosome 2. Human and rat urocortin share 95% identity within the mature peptide region. Human urocortin binds with high affinity to CRF receptor types 1, 2a, and 2b, stimulates cAMP accumulation from cells transfected with these receptors and acts in vitro to release ACTH from dispersed rat anterior pituitary cells.
Cayman Chemical SynthetIc NIgerose 25mg
A disaccharide; prevents increases in MDA and ROS levels and inhibits LDH release in HL-60 cells post-cryopreservation at 150 µM in combination with salidroside
Sigma Aldrich Fine Chemicals Biosciences Calcitonin Gene Related Peptide Fragment 8-37 human >=97% (HPLC), powder | 119911-68-1 | MFCD00133153 | 0.5MG
Calcitonin Gene Related Peptide Fragment 8-37 human >=97% (HPLC), powder | Purity: >=97% (HPLC) | Mol Wt: 3125.59 | 119911-68-1 | MFCD00133153 | 0.5MG
Medchemexpress LLC Neuropeptide FF (NPFF) | 99566-27-5 | 99.4% | 1081.27 | 1 MG
Neuropeptide FF (NPFF) is an octapeptide from the RF-amide family, acting as an agonist for NPFF1 and NPFF2 receptors. It is involved in diverse physiological processes, including abstinence syndrome, memory, and pain modulation. Present in the mammalian central nervous system and periphery, NPFF is key for research into opioid tolerance, analgesia, and various pain conditions.
- Agonist for NPFF1 and NPFF2 receptors
- Induces abstinence syndrome
- Exerts antiopioid and analgesic effects
- Regulates memory, autonomic, neuroendocrine functions
- Modulates pain and opioid antinociception
- Reduces food and stimulates water intake
- Alters cardiovascular parameters
- Research tool for opioid tolerance and morphine-induced analgesia
- Applied in studies of hypertension, nociception, and pain types
Bachem a-Synuclein Binding Peptide Trifluoroacetate
a-Synuclein Binding Peptide Trifluoroacetate, Ac-Lys-Asp-Gly-Ile-Val-Asn-Gly-Val-Lys-Ala-NH2, 2243207-00-1, C45H80N14O14, Mr 1041.20, 1mg. Cheruvara and coworkers conducted a single step selection followed by two rounds of competition selection protein-fragment complementation assay (PCA) in order to derive a-synuclein (a-syn) binders capable of inhibiting aggregation. They isolated a 10-residue peptide antagonist, corresponding to the sequence of a-synuclein binding peptide that potently inhibits a-synuclein aggregation and associated toxicity at 1:1 stoichiometry.
Active Motif Histone H3K9me3 Peptide - biotinylated
Histone H3K9me3 Peptide for the study of proteins that interact with histones and that read, write or erase histone modifications.