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Various organic compounds consisting of carbon, hydrogen, and oxygen atoms that are found in foods and living tissues; typically broken down to release energy; includes sugars, sugar alcohols, sugar acids and derivatives, glycosyl compounds, and more.
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D-α-hydroxyglutaric acid disodium is the disodium salt of the D-enantiomer of 2-hydroxyglutaric acid, provided as a 10 mM solution (1 mL) or as solids. It is used as a biochemical research reagent to probe α-ketoglutarate-dependent enzymes, metabolic and mitochondrial function, and oncometabolite biology. Purity is typically 98.0%.
Available as 10 mM solution in water (1 mL) or as solid quantities for flexibility.
Useful for studies of α-ketoglutarate-dependent dioxygenases and epigenetic modifiers.
Reported to increase reactive oxygen species and inhibit ATP synthase and mTOR signaling.
High purity (98.0%) suitable for biochemical and cellular assays.
Documents provided for quality and safety: data sheet, COA, and SDS.
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Carvedilol phosphate hemihydrate is a non-selective β/α-1 blocker with multiple actions, including inhibiting lipid peroxidation with an IC50 of 5 μM. This compound acts as an antihypertensive agent with potential use in angina and congestive heart failure. Additionally, it functions as an autophagy inducer that inhibits the NLRP3 inflammasome.
Non-selective β/α-1 blocker
Inhibits lipid peroxidation
Antihypertensive agent
Potential use in angina and congestive heart failure
Autophagy inducer
Inhibits NLRP3 inflammasome
Inhibits superoxide generation by activated human neutrophils (IC50 of 28 μM)
Scavenges oxygen free radicals in a cell-free system (IC50 of 25 μM)
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Complement factor D-IN-2 is an inhibitor of complement factor D. It targets factor D and inhibits the complement cascade at an early and essential point in the alternative complement pathway. This compound can be used for the research of autoimmune diseases by reducing the excessive activation of complement factor D.
Inhibits complement cascade at an early stage
Reduces excessive activation of complement factor D
Useful for research into autoimmune diseases
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The primary attribute of DDM is its capability to extract hydrophobic proteins while maintaining the solution-phase protein conformation DDM also allows the protein to be reformed following denaturization Most membrane-bound proteins are -helix bundles which are less robust to changes in their cellular environment DDM offers a detergent capable of preserving these proteins This is in contrast to other harsher ionic detergents that destabilize and permanently denature -helical membrane-bound proteins DDM has been used to solubilize the multidrug-transporter protein EmrE as well as the nucleoside-specific porin protein Tsx
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Sucrose octasulfate sodium is a derivative of sulfated oligosaccharides that acts as a matrix metalloproteinase (MMP) inhibitor. It stimulates the release of somatostatin-like immunoreactivity (SLI) from the stomach by directly affecting D cells in the gastric mucosa, contributing to its ulcer-healing effect. It can also be used as a pharmaceutical excipient and has shown to improve wound closure in diabetic foot ulcers and venous leg ulcers.