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Various organic compounds consisting of carbon, hydrogen, and oxygen atoms that are found in foods and living tissues; typically broken down to release energy; includes sugars, sugar alcohols, sugar acids and derivatives, glycosyl compounds, and more.
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Cyclosporin D (CAS 63775-96-2) is a structural analogue of Cyclosporin A with comparatively reduced immunosuppressive activity Mechanistically it weakly inhibits lymphocyte proliferation induced by mitogens such as PHA PWM PMA and Ca 2 and suppresses Ca 2 /calmodulin-dependent phosphorylation of elongation factor 2 (EF-2) in mouse pancreatic cells In preclinical models Cyclosporin D overcomes Adriamycin resistance in multidrug-resistant ovarian cancer cells and inhibits TPA-induced ear edema and alkaline phosphatase activity in mice Additionally it displays inhibitory effects on the growth of malarial parasites both in vitro and in vivo Cyclosporin D serves as a standard in Cyclosporin A quantification and as a research tool in immunology oncology and antiparasitic studies
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