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Various organic compounds consisting of carbon, hydrogen, and oxygen atoms that are found in foods and living tissues; typically broken down to release energy; includes sugars, sugar alcohols, sugar acids and derivatives, glycosyl compounds, and more.
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Sucralose (CAS 56038-13-2) is a synthetic chlorinated disaccharide widely employed as a noncaloric sweetener in biomedical and nutritional research It functions by binding to the sweet taste receptors (T1R2/T1R3) on the tongue eliciting a perceived sweetness substantially greater than that of sucrose Sucralose is minimally metabolized in the human body resulting in negligible caloric contribution and low systemic absorption Its metabolic stability and lack of glycemic impact make it a useful tool for investigating carbohydrate metabolism taste receptor signaling pathways and the physiological effects of nonnutritive sweeteners
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CDK1/Cyc B-IN-1 is a selective inhibitor of the CDK1/Cyc B complex with an IC50 of 97 nM. It induces apoptosis and G2/M cell cycle arrest, demonstrating broad-spectrum cytotoxic action against various cancer cell lines.
Selective inhibitor of CDK1/Cyc B complex
Induces apoptosis
Causes G2/M cell cycle arrest
Exhibits broad-spectrum cytotoxic action against cancer cell lines
Available in various quantities
Recommended storage conditions for powder and in solvent
Soluble in DMSO
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DL- -Hydroxyglutaric acid disodium salt (CAS 40951-21-1) is a small molecule analogue of -hydroxyglutaric acid a metabolite implicated in neurometabolic disorders In humans aberrant accumulation of D- -hydroxyglutaric acid occurs in D-2-hydroxyglutaric aciduria associated with mutations in isocitrate dehydrogenase (IDH) enzymes particularly IDH1 and IDH2 These mutations alter normal metabolic flux leading to overproduction of D- -hydroxyglutaric acid from 2-oxoglutarate In preclinical studies elevated levels of this metabolite are detectable in IDH1-mutant glioma models and non-invasive quantification is feasible via magnetic resonance spectroscopy DL- -Hydroxyglutaric acid disodium salt is utilized in research investigating metabolic dysregulation biomarker development and disease mechanisms linked to IDH mutations and gliomagenesis
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