[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P is a synthetic peptide derivative of Substance P containing D-amino acid substitutions. It acts as a biased agonist at selected neuropeptide and chemokine receptors, modulates G-protein signaling (activates G12), influences MAPK pathways, and promotes neutrophil chemotaxis and Ca2+ mobilization.
- Peptide sequence: {d-Arg}-Pro-Lys-Pro-{d-Phe}-Gln-{d-Trp}-Phe-{d-Trp}-Leu-Leu-NH2
- Molecular formula: C79H109N19O12
- Molecular weight: 1516.83 g/mol
- Purity: 98.48% (HPLC)
- Typical applications: receptor signaling studies, biased agonism research, and neutrophil chemotaxis assays