Lipids and Lipid Derivatives
Cayman Chemical PhytnIc AcId-d3 10mg
An internal standard for the quantification of phytanic acid by GC- or LC-MS
Cayman Chemical -NIcotIn-d3 5mg
An internal standard for the quantification of (±)-nicotine by GC- or LC-MS
Apexbio Technology LLC Cyproterone Acetate 427-51-0 250mg
Cyproterone Acetate (CAS 427-51-0) is a small-molecule antagonist targeting the androgen receptor (AR) It is designed to inhibit AR activation thereby suppressing androgen-mediated cellular signaling Cyproterone Acetate exerts its biological activity primarily through competitive binding to AR displacing endogenous androgen ligands and blocking receptor activation and downstream signaling In experimental assays Cyproterone Acetate demonstrates AR inhibition with an IC50 value of approximately 7 1 nM At higher concentrations (EC50 around 4 0 M) it may also exhibit partial agonist activity on the AR pathway Based on these pharmacological properties Cyproterone Acetate holds research potential in studies of androgen-dependent biological processes AR signaling mechanisms and hormone-sensitive pathologies such as prostate cancer or androgen-related metabolic conditions
Selleck Chemical LLC Dexamethasone 21-phosphate
Dexamethasone phosphate disodium is a glucocorticoid receptor agonist with both anti-inflammatory and anti-oxidative effects
Medchemexpress LLC HY-113313 5mg Medchemexpress, Aldosterone CAS:52-39-1 Purity:>98%
Medchemexpress, HY-113313 5mg Aldosterone CAS:52-39-1 Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
TARGETMOL CHEMICALS INC HYDROCORTISONE ACEPONATE 5MG
Also available in 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. Hydrocortisone aceponate (Hydrocortisone 17-propionate 21-acetate) is an effective topical glucocorticoid used in the form of a cream to treat various skin diseases. purity: 99%
Medchemexpress LLC Dexamethasone (Water Soluble) | 50-02-2 | 98.9% | 50 MG
Dexamethasone (Hexadecadrol) Water Soluble is a water-soluble form of Dexamethasone, acting as a glucocorticoid receptor agonist and apoptosis inducer. It serves as a common disease inducer in experimental animals, suitable for models of muscle atrophy, hypertension, and depression. It also inhibits inflammatory miRNA-155 exosomes and reduces inflammatory factors, with potential in COVID-19 research.
- Glucocorticoid receptor agonist and apoptosis inducer
- Used for muscle atrophy, hypertension, and depression models
- Inhibits inflammatory miRNA-155 exosomes; reduces inflammatory factors
- Potential for COVID-19 research
- Solubility in H2O: ≥ 100 mg/mL
- Modulates key transcription factors
- Potently inhibits GM-CSF release
Selleck Chemical LLC Prednisone acetate
Prednisone acetate (Betapar Cortan Deltasone Fernisone Meticorten Prednisone 21-acetate) is a glucocorticoid steroid that can be used as a glucocorticoid receptor agonist with anti-inflammatory and immunomodulating properties
Medchemexpress LLC Hydrocortisone cypionate | 508-99-6 | 486.64 | 5 MG
Hydrocortisone cypionate is a synthetic glucocorticoid corticosteroid and a corticosteroid ester. It is intended for research use only.
- Down-regulates GR transcript in hCMEC/D3 cells in a dose-dependent manner.
- Supplementation leads to a significant increase in TER across the hCMEC/D3 monolayer.
- Treated dendritic cells (DCs) exhibit decreased expression of MHC II molecules, costimulatory molecule CD86, and DC-specific marker CD83.
- Treated dendritic cells (DCs) show strongly reduced IL-12 secretion.
- Treated dendritic cells (DCs) inhibit IFN-γ production but induce increased release of IL-4.
- Reduces post-ischemic oxidative stress, perfusion pressure, and transudate formation.
- Inhibits post-ischemic shedding of syndecan-1, heparan sulfate, and hyaluronan.
- Inhibits histamine release from mast cells.
Cambridge Isotope Laboratories GLYCOCHOLIC ACID (2,2,4,4-D4, 98%) (CONTAINS ~4% WATER), 10 MG
GLYCOCHOLIC ACID (2,2,4,4-D4, 98%) (CONTAINS ~4% WATER), 10 MG
Medchemexpress LLC Glycocholic acid | 475-31-0 | 465.62 | 10 G
Glycocholic acid is a bile acid with anticancer activity, targeting against pump resistance-related and non-pump resistance-related pathways. It works by modulating P-gp and MRPs, and regulating apoptosis-related pathways when combined with anticancer drugs.
- Increases cytotoxicity of epirubicin
- Increases intracellular accumulation and absorption of epirubicin
- Intensifies epirubicin-induced apoptosis
- Reduces mRNA expression levels of human intestinal MDR1, MDR-associated protein (MRP)1, and MRP2
- Downregulates the MDR1 promoter region
- Suppresses mRNA expression of Bcl-2
- Induces mRNA expression of Bax
- Increases Bax-to-Bcl-2 ratio and mRNA levels of p53, caspase-9 and -3
Cambridge Isotope Laboratories Sodium monofluoroacetate (unlabeled) 1 mg/mL in water 1 2 mL
Sodium monofluoroacetate (unlabeled) 1 mg/mL in water 1 2 mL
Cambridge Isotope Laboratories Permethrin (cis/trans mix) (unlabeled) 100 ug/mL in nonane 1 2 mL
Permethrin (cis/trans mix) (unlabeled) 100 ug/mL in nonane 1 2 mL
Medchemexpress LLC Glycocholic acid | 475-31-0 | 465.62 | 5 G
Glycocholic acid is a bile acid with anticancer activity, targeting pump resistance-related and non-pump resistance-related pathways. It is for research use only and not sold to patients.
- Appearance: Solid
- Color: White to off-white
- Classification: Steroids
- Initial source: Endogenous metabolite, human gut microbiota metabolites
- Increases the cytotoxicity of epirubicin
- Modulates P-gp and MRPs as well as regulating apoptosis-related pathways