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Dexamethasone phosphate disodium (Standard) is the analytical standard of Dexamethasone phosphate (disodium). It is an orally active Glucocorticoid receptor agonist intended for research and analytical applications. It is commonly used as a reference standard in qualitative, quantitative, and methodological research experiments.
Used in HPLC, GC, and MS applications
Orally active glucocorticoid receptor agonist
Reference standard for research and analytical use
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Estradiol benzoate is a HBx protein inhibitor that inhibits androgen and hepatitis B virus (HBV) transcription and replication. It also shows antifertility effects, anti-Toxoplasma gondii activity, and can improve memory behavior in Ovariectomy (Ovx) female mice.
Inhibits HBx protein
Inhibits androgen transcription
Inhibits hepatitis B virus (HBV) transcription and replication
Exhibits antifertility effects
Shows anti-Toxoplasma gondii activity
May improve memory behavior in Ovariectomy (Ovx) female mice
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RK-701 is a highly selective potent and low-toxicity inhibitor of histone methyltransferases G9a and GLP1 with IC50 values of 23-27 nM and 53 nM RK-701 treatment induces fetal globin expression in human erythroid cells and in mice and plays an essential role in -globin induction RK-701 is used in the research of sickle cell disease
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Digitonin is a nonionic saponin steroid derived from the plant Digitalis purpurea It is useful for creating Digitonin-cholesterol complexes which form when Digitonin disrupts the cell membrane and binds with cholesterol in a nearly 1 1 stoichiometric ratio When precipitated from ethanolic solutions these complexes form flat lamellar sheets Digitonin s cholesterol displacing properties have been used in newer applications to quantify the rate of lysosomal membrane permeabilization (LMP) a new technique developed to bypass traditional cell death pathways Digitonin permeabilizes plasma membranes but leaves lysosomal membranes intact allowing for a quantifiable measurement of lysosomal hydrolases and comparison to normal cellular enzyme activity Digitonin has been shown to induce hemolysis in red blood cells
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Chemical. CAS 17695-48-6. Formula C26H38O4. Molecular Weight 414.59. 4-Methylumbelliferyl palmitate 4-MUP is a fluorogenic substrate for lysosomal acid lypase LAL. 4-MUP is cleaved by LAL or by other acid lipases to release the fluorescent moiety 4-MU. Recent advances allow the assessment of LAL activity in very small blood volumes using 4-MUP. Cholesterol ester storage disease and Wolman disease are recessive autosomal disorders caused by a deficiency in lysosomal acid lipase LAL, also known as cholesteryl ester hydrolase. Spectral data 4-MU fluorescence is pH-dependent. lambdaex 320nm pH 1.97-6.72 and 360nm pH 7.12-10.3 lambdaem 445-455nM increasing as pH decreases.
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