Daminozide is a plant growth regulator that functions as a selective inhibitor of human KDM2/7 histone demethylases. It exhibits IC50 values of 0.55, 1.5, and 2.1 μM for PHF8, KDM2A, and KIAA1718, respectively, and demonstrates over 100-fold selectivity for the KDM2/7 subfamily compared to other demethylase subfamily members.
- Selective inhibitor of human KDM2/7 histone demethylases
- IC50s of 0.55, 1.5, and 2.1 μM for PHF8, KDM2A, and KIAA1718
- Greater than 100-fold selectivity for KDM2/7 subfamily