Solvents
Columbus Chemical, Inc. DENATURED ETHANOL 4L 200 PRF
This item has a minimum order quantity of 2 per supplier requirements. DENATURED ETHANOL 4L 200 PRF
Medchemexpress LLC Melperone-d4 hydrochloride | 1219798-80-7 | 99.8% | 1 MG
Melperone-d4 hydrochloride is a deuterium-labeled form of Melperone hydrochloride, a butyrophenone with atypical antipsychotic properties. It functions as a multireceptor antagonist, targeting 5-HT2A, dopamine D2, α1-adrenergic, and α2-adrenergic receptors, along with weaker binding to other receptors. It also inhibits CYP2D6. This compound is valuable for research into schizophrenia and agitation in the elderly.
- Deuterium-labeled compound
- Atypical antipsychotic properties
- Functions as a multireceptor antagonist
- Targets 5-HT2A, dopamine D2, α1-adrenergic, and α2-adrenergic receptors
- Inhibits CYP2D6
- Useful for research on schizophrenia and agitation in the elderly
- Can be used as a tracer
- Suitable as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Busulfan-d8 | 116653-28-2 | 99.7% | 1 MG
Busulfan-d8 is a deuterium labeled Busulfan, functioning as a potent alkylating antineoplastic agent. It causes DNA damage by cross-linking DNAs and DNA and proteins, inhibits thioredoxin reductase, and induces apoptosis. This compound acts as an immunosuppressive and myeloablative chemotherapeutic agent.
- Deuterium labeled compound
- Functions as a potent alkylating antineoplastic agent
- Causes DNA damage by cross-linking DNAs and DNA and proteins
- Inhibits thioredoxin reductase and induces apoptosis
- Acts as an immunosuppressive and myeloablative chemotherapeutic agent
- Can be used as a tracer for quantitation during drug development
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Apexbio Technology LLC Etodolac 41340-25-4 10mM (in 1mL DMSO)
Etodolac (CAS 41340-25-4) is a selective cyclooxygenase-2 (COX-2) inhibitor belonging to the class of non-steroidal anti-inflammatory drugs (NSAIDs) It exhibits inhibitory activity against COX-2 with an IC50 of 53 5 nM Etodolac is commonly utilized for research involving inflammatory conditions such as osteoarthritis and rheumatoid arthritis In isolated rabbit articular chondrocytes stimulated with TNF Etodolac prevented apoptotic cell shrinkage and suppressed caspase-3/7 activation Conversely in human malignant rhabdoid tumor cells (FRTK-1) Etodolac induced apoptosis in a dose-dependent manner increasing activities of caspase-3 -8 and -9
Medchemexpress LLC Nicorandil-d4 | 1132681-23-2 | 99.8% | 5 MG
Nicorandil-d4 is the deuterium-labeled form of Nicorandil, a potent potassium channel activator. It targets vascular nucleoside diphosphate-dependent K+ channels and cardiac ATP-sensitive K+ channels (KATP), exhibiting vasodilatory and cardioprotective effects. This compound has potential applications for angina and ischemic heart diseases.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Storage (Powder): -20°C for 3 years; 4°C for 2 years
- Storage (In solvent): -80°C for 6 months; -20°C for 1 month
Apexbio Technology LLC Taxifolin 480-18-2 10mM (in 1mL DMSO)
Taxifolin (CAS number 480-18-2) a bioactive flavonoid isolated primarily from coniferous species of the Pinaceae family exhibits notable antioxidant anti-inflammatory and chemopreventive properties It functions primarily through free radical scavenging and modulation of oxidative stress pathways reducing cellular damage associated with reactive oxygen species (ROS) Taxifolin further influences various signaling cascades involved in inflammation and apoptosis regulation Due to these pharmacological attributes it is widely utilized in biomedical research exploring oxidative stress-related diseases inflammatory conditions and potential cancer therapeutic avenues For optimal stability maintain storage conditions sealed dry and cool
Medchemexpress LLC Tolbutamide-d9 | 1219794-57-6 | 99.0% | 1 MG
Tolbutamide-d9 is a deuterium-labeled Tolbutamide. Tolbutamide is classified as a first-generation potassium channel blocker and a sulfonylurea oral hypoglycemic agent. This compound can be used as a tracer or an internal standard for quantitative analysis.
- Used as a tracer in drug development
- Serves as an internal standard for quantitative analysis by techniques such as NMR, GC-MS, or LC-MS
- Incorporates stable heavy isotopes into drug molecules
- Deuteration may influence pharmacokinetic and metabolic profiles of drugs
Apexbio Technology LLC Bexarotene 153559-49-0 10mM (in 1mL DMSO)
Bexarotene is a synthetic selective agonist for retinoid X receptors (RXRs) a subclass of nuclear hormone receptors involved in the regulation of gene transcription Upon binding to RXRs Bexarotene modulates the expression of target genes associated with cell differentiation proliferation and apoptosis Due to this mechanism Bexarotene is commonly employed in research investigating tumor growth inhibition cellular differentiation pathways and apoptosis induction Researchers also frequently utilize this retinoid derivative to elucidate RXR-mediated signaling pathways in oncology and to explore potential therapeutic applications for various malignancies
Apexbio Technology LLC Anacetrapib (MK-0859) 875446-37-0 10mM (in 1mL DMSO)
Anacetrapib (MK-0859 CAS 875446-37-0) is a selective inhibitor of cholesteryl ester transfer protein (CETP) an enzyme involved in mediating the transfer of cholesteryl esters and triglycerides between lipoproteins In biochemical assays anacetrapib exhibits potent inhibition of CETP-driven lipid transfer with reported IC50 values of 16 nM for cholesteryl ester transfer and 29 nM for triglyceride transfer Metabolically it undergoes oxidation via CYP3A4 to form metabolites M1 M2 and M3 Due to its effect of significantly lowering LDL cholesterol and elevating HDL cholesterol anacetrapib is studied in research related to primary hypercholesterolemia and mixed dyslipidemia
Apexbio Technology LLC Forskolin 66575-29-9 10mM (in 1mL DMSO)
Forskolin (CAS 66575-29-9) is a diterpenoid isolated from the plant Coleus forskohlii known to directly activate adenylate cyclase type I thereby elevating cellular cyclic AMP (cAMP) concentrations It exhibits an IC50 of approximately 41 nM against adenylate cyclase By increasing intracellular cAMP forskolin modulates signaling pathways involved in inflammation and oxidative stress reducing macrophage activation and subsequent production of thromboxane B2 and superoxide Forskolin has been explored in various experimental models and clinical contexts including cardiovascular disorders diabetes mellitus and asthma research
Medchemexpress LLC (R)-Amlodipine-d4 | 1346616-97-4 | 500 UG
(R)-Amlodipine-d4 is a deuterium-labeled form of (R)-Amlodipine. Stable heavy isotopes of hydrogen, carbon, and other elements are incorporated into drug molecules for use as tracers in drug development for quantitation. Deuteration has gained attention due to its potential to influence the pharmacokinetic and metabolic profiles of drugs.
- Deuterium-labeled form of (R)-Amlodipine
- Stable heavy isotopes for use as tracers
- Potential to influence pharmacokinetic and metabolic profiles of drugs