Solvents
Medchemexpress LLC Guanidine-d5 hydrochloride | 108694-93-5 | 98% | 50 MG
Guanidine-d5 hydrochloride is the deuterium labeled form of Guanidine hydrochloride, a strong chaotrope and protein denaturant. This compound is intended for research use only.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Apexbio Technology LLC Dihydromyricetin 27200-12-0 10mM (in 1mL DMSO)
Dihydromyricetin also termed Ampelopsin is a natural flavanonol compound frequently investigated for its antioxidant and anticancer properties It exerts biological effects primarily through modulation of molecular pathways involving oxidative stress responses apoptosis regulation and GABA-A receptor enhancement at benzodiazepine binding sites Studies indicate dihydromyricetin acts as a positive allosteric modulator on GABA-A receptors suggesting potential for research related to alcohol intoxication and associated neural mechanisms In cellular assays dihydromyricetin demonstrates antiproliferative activity against various cancer cell lines typically exhibiting IC50 concentrations in the micromolar range Thus this compound is widely utilized in biomedical research including cell signaling pathway analysis antioxidant mechanism exploration and studies examining potential therapeutic roles in oncology and neuropharmacology
Cambridge Isotope Laboratories L-GLUTAMINE (13C5, 97-99%; D5, 97-99%; 15N2, 97-99%), 0.25 G
L-GLUTAMINE (13C5, 97-99%; D5, 97-99%; 15N2, 97-99%), 0.25 G
Medchemexpress LLC Spermine-d8 tetrahydrochloride | 1173022-85-9 | 95% | 1 MG
Spermine-d8 tetrahydrochloride | 1173022-85-9 | 95% | 1 MG
Medchemexpress LLC Dimetridazole-d3 (1,2-Dimethyl-5-nitroimidazole-d3) | 64678-69-9 | 99.8% | 1 MG
Dimetridazole-d3 (1,2-Dimethyl-5-nitroimidazole-d3) is a deuterium-labeled version of Dimetridazole, a nitroimidazole antibiotic that inhibits protein synthesis in Campylobacter jejuni cultures and has genotoxic properties. This compound is suitable for research on protozoal and bacterial infections.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuteration can influence the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Puromycin-d3 dihydrochloride | 1 MG
Puromycin-d3 dihydrochloride is a deuterium-labeled aminonucleoside antibiotic that inhibits protein synthesis. Stable heavy isotopes have been incorporated into this drug molecule for use as a tracer in drug development. Deuteration can impact the pharmacokinetic and metabolic profiles of drugs.
- Inhibits protein synthesis.
- Deuterium labeled compound.
- Functions as a tracer for quantitation in drug development.
- Affects pharmacokinetic and metabolic profiles.
- Molecular formula: C₂₂H₂₈D₃Cl₂N₇O₅
- Molecular weight: 547.45 g/mol
- Targets bacterial, antibiotic, and isotope-labeled compounds.
- Soluble in methanol, DMSO, and ethanol.
Medchemexpress LLC Clascoterone-d5 | 95.0% | 407.55 g·mol⁻¹ | C24H29D5O5 | 1mg
Clascoterone-d5 (Cortexolone 17 alpha-propionate-d5) is the deuterated analog of Clascoterone Clascoterone is a topical and peripheral androgen antagonist[1][2][3]
Medchemexpress LLC 2-mercaptoethanol-d6 | 203645-37-8 | MFCD00209754 | 99.7% | 84.17 g/mol | C2D6OS | 100mg
2-Mercaptoethanol-d6 is deuterium labeled 2-Mercaptoethanol[1]
Medchemexpress LLC Acetylcholine-d9 (chloride) | 344298-95-9 | 99.0% | 5 MG
Acetylcholine-d9 (chloride) is a deuterium-labeled Acetylcholine chloride, a neurotransmitter and a potent, BBB-permeable cholinergic agonist. It modulates dopaminergic neuron activity by stimulating nicotinic acetylcholine receptors (nAChRs) and inhibits p53 mutant peptide aggregation in vitro.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Heclin | 890605-54-6 | 98.2% | 283.32 | 10 MG
Heclin is an inhibitor of HECT E3 ubiquitin ligases, targeting Smurf2, Nedd4, and WWP1 with IC50 values of 6.8, 6.3, and 6.9 μM, respectively. It is utilized in research for gastric cancer.
- Inhibits Smurf2, Nedd4, and WWP1
- Used for gastric cancer research
- Inhibits cell viability and IGF1 signaling in BGC803 and MKN45 cell lines
- Ameliorates epinecidin-1-mediated MyD88 degradation in Raw264.7 cells
- Reduces phosphorylation of Akt
Apexbio Technology LLC Z-Ligustilide 4431-01-0 10mM (in 1mL DMSO)
Ligustilide a bioactive compound purified from Angelica essential oil exhibits anti-inflammatory and anti-apoptotic properties and is commonly investigated for circulatory improvement and inflammation-related studies In vitro data demonstrate ligustilide s capability to interfere with apoptotic signaling pathways in neuronal cell models by modulating factors such as mitochondrial cytochrome C release Bcl-2/Bax ratios and Caspase-3 expression Additionally in animal models of ovariectomy-induced osteoporosis ligustilide administration reduces inflammatory markers including NF- B activation and production of cytokines (TNF- IL-1 ) and enzymes (COX-2 iNOS) suggesting potential therapeutic relevance in inflammation-associated conditions
Medchemexpress LLC 1-Naphthyl-d7 N-methylcarbamate | 362049-56-7 | 99% | 5 MG
Carbaryl-d7 is a deuterium-labeled version of Carbaryl, an acetylcholinesterase inhibitor. It functions by preventing the breakdown of acetylcholine in the synaptic cleft, leading to acetylcholine accumulation and neurotoxicity. This compound is primarily used as an insecticide.
- Can be used as a tracer.
- Functions as an internal standard for quantitative analysis using NMR, GC-MS, or LC-MS.
- Incorporates stable heavy isotopes for pharmacokinetic and metabolic studies.
Chemscene ChemScene | tert-Butyl 3-oxo-3,4-dihydroquinoxaline-1(2H)-carboxylate | 250MG | CS-0097470 | 0.98 | 148858-04-2| MFCD17170819 | 248.28
ChemScene | tert-Butyl 3-oxo-3,4-dihydroquinoxaline-1(2H)-carboxylate | 250MG | CS-0097470 | 0.98 | 148858-04-2| MFCD17170819 | 248.28
Medchemexpress LLC (S)-Ofloxacin-d3 | 2208780-63-4 | 98.0% | 1 MG
(S)-Ofloxacin-d3 is a deuterium-labeled version of Levofloxacin, a synthetic fluoroquinolone. It acts as an antibacterial agent by inhibiting bacterial DNA gyrase, which stops DNA replication.
- Used as a tracer
- Functions as an internal standard for quantitative analysis via NMR, GC-MS, or LC-MS
- Contains stable heavy isotopes for quantitation during drug development
- Potential to influence pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC Pentoxifylline-d5 | 1185995-18-9 | 99.9% | 50 MG
Pentoxifylline-d5 is a deuterium-labeled version of Pentoxifylline. The unlabeled compound, Pentoxifylline (BL-191), acts as a haemorheological agent and is an orally active, non-selective phosphodiesterase (PDE) inhibitor. It demonstrates immune modulation, anti-inflammatory, hemorheological, anti-fibrinolytic, and anti-proliferation effects. This compound can be utilized in research concerning peripheral vascular disease, cerebrovascular disease, and other conditions involving impaired regional microcirculation.
- Used as a tracer.
- Functions as an internal standard for quantitative analysis through methods like NMR, GC-MS, or LC-MS.
- Stable heavy isotopes are incorporated into drug molecules for quantitation during drug development.
- Deuteration can influence the pharmacokinetic and metabolic profiles of compounds.