Solvents
Apexbio Technology LLC Baicalein 491-67-8 10mM (in 1mL DMSO)
Baicalein is a natural flavonoid compound extracted from the medicinal herb Scutellaria baicalensis known to function as an inhibitor of lipoxygenase enzymes It selectively inhibits the 12-lipoxygenase (12-LOX) mediated metabolic pathway involved in arachidonic acid metabolism subsequently modulating inflammatory responses and cell proliferation signaling Baicalein demonstrates bioactivity as reflected by reported IC50 values typically ranging from 0 6 M to 2 5 M against purified human platelet 12-LOX enzyme It is utilized in biomedical research primarily to study inflammation pathways tumor cell proliferation processes and mechanisms underlying apoptosis induction
Sigma Aldrich Fine Chemicals Biosciences Citric acid-13C6 99 atom % 13C, 97% (CP) | 287389-42-8 | MFCD01075573 | 100MG
Citric acid-13C6 99 atom % 13C, 97% (CP) | Purity: 97% (CP) | Mol Wt: 198.08 | 287389-42-8 | MFCD01075573 | 100MG
Cayman Chemical PItavastatIn lacton-d4 500ug
An internal standard for the quantification of pitavastatin lactone by GC- or LC-MS
Medchemexpress LLC Glycine-1-13C,15N | 112898-03-0 | MFCD00064425 | 99.5% | 77.053 g/mol | C2H5NO2 | 5mg
Glycine-1-13C 15N is the 13C- and 15N-labeled Glycine Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors
Apexbio Technology LLC Erlotinib 183321-74-6 10mM (in 1mL DMSO)
Erlotinib (CAS 183321-74-6) is an orally bioavailable reversible inhibitor targeting the epidermal growth factor receptor (EGFR) tyrosine kinase It acts by competitively binding the intracellular ATP-binding domain of EGFR thereby preventing receptor autophosphorylation and subsequent signaling cascades involved in proliferation angiogenesis and cell survival In biochemical assays Erlotinib demonstrates potent inhibition of EGFR tyrosine kinase (IC50 2 nmol/L) and cellular autophosphorylation of EGFR (IC50 20 nmol/L) Due to its selective interference with EGFR-mediated signaling Erlotinib is extensively employed in oncology research particularly in studies on EGFR-expressing tumor models
Medchemexpress LLC Thiamphenicol-d3 | 2211914-19-9 | 99.5% | 1 MG
Thiamphenicol-d3 is a deuterium labeled form of Thiamphenicol, a broad-spectrum antimicrobial antibiotic. As a methyl-sulfonyl derivative of Chloramphenicol, it functions by binding to the 50S ribosomal subunit, which inhibits protein synthesis. This mechanism provides a bacteriostatic effect against a range of bacteria, including Gram-negative, Gram-positive aerobic, and anaerobic types.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Apexbio Technology LLC PCI-32765 (Ibrutinib) 936563-96-1 10mM (in 1mL DMSO)
PCI-32765 (Ibrutinib) is a small-molecule inhibitor targeting Bruton s tyrosine kinase (BTK) a cytoplasmic kinase integral to B-cell receptor (BCR) signaling By covalently binding to BTK active sites PCI-32765 disrupts downstream signaling cascades essential for B-cell maturation and activation Dysfunction or inhibition of BTK correlates with impaired B-cell development and reduction in autoantibody production PCI-32765 is commonly utilized in biomedical research to explore BTK-dependent signaling pathways elucidate molecular mechanisms underlying B-cell mediated disorders and examine therapeutic potential in B-cell malignancies and autoimmune models
Medchemexpress LLC Ranolazine-d3 | 1054624-77-9 | 99.5% | 100 MG
Ranolazine-d3 is a deuterium labeled anti-angina agent that inhibits the late phase of inward sodium current (INa and IKr with IC50 values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure. It also functions as a partial fatty acid oxidation inhibitor and is intended for research use only.
- Used as a tracer.
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
eMolecules 312959-24-3 | Ditert-butyl(cyclopentyl)phosphane; iron; (2,3,4,5-tetraphenylcyclopentyl)benzene | Manchester Organics720.803 | C48H57FeP | 0.000 | [Fe].CC(C)(C)P(C1CCCC1)C(C)(C)C.c1ccc(cc1)C1C(C(C(C1c1ccccc1)c1ccccc1)c1ccccc1)c1ccccc1 | 1g | 564875953
Ditert-butyl(cyclopentyl)phosphane; iron; (2,3,4,5-tetraphenylcyclopentyl)benzene | Manchester Organics | 312959-24-3720.803 | C48H57FeP | 0.000 | [Fe].CC(C)(C)P(C1CCCC1)C(C)(C)C.c1ccc(cc1)C1C(C(C(C1c1ccccc1)c1ccccc1)c1ccccc1)c1ccccc1 | 1g | 564875953
Apexbio Technology LLC GW4064 278779-30-9 10mM (in 1mL DMSO)
GW4064 (CAS 278779-30-9) is a non-steroidal agonist targeting the farnesoid X receptor (FXR) a nuclear receptor involved in lipid and cholesterol regulation Reported EC50 values of GW4064 for FXR activation are approximately 15 nM in isolated receptor assays and 90 nM in human FXR-transfected cell studies In animal models including KK-Ay and ob/ob mice GW4064 administration was associated with reduced serum triglyceride (TG) concentrations and diminished very-low-density lipoprotein (VLDL) production However due to limitations such as poor solubility chemical instability under UV exposure and a potentially toxic stilbene pharmacophore GW4064 primarily serves as a research tool for investigating FXR signaling pathways
Apexbio Technology LLC Y-27632 dihydrochloride 129830-38-2 10mM (in 1mL DMSO)
Y-27632 dihydrochloride (CAS 129830-38-2) is a small-molecule inhibitor targeting ROCK kinases (Rho-associated protein kinases) specifically interacting with the catalytic domains of ROCK-1 and ROCK-2 It inhibits their kinase activity with an IC50 of approximately 140 nM By targeting ROCK signaling Y-27632 disrupts Rho-mediated formation of cellular stress fibers influences cell cycle progression from G1 to S phase and interferes with cytokinesis It is commonly utilized in studies investigating cell proliferation cytoskeletal organization and stem cell viability
Medchemexpress LLC Lidocaine-d10 hydrochloride | 1189959-13-4 | 99.6% | 5 MG
Lidocaine-d10 hydrochloride is the deuterium-labeled Lidocaine hydrochloride. It inhibits sodium channels involving complex voltage and use dependence, and decreases the growth, migration, and invasion of gastric carcinoma cells by up-regulating miR-145 expression and inactivating MEK/ERK and NF-κB signaling pathways. This amide derivative has potential for research into ventricular arrhythmia and is intended for research use only.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
American Radiolabeled Chemicals Inc TRIBUT PO4 3H 250UC
Tributylphosphate-butyl-2,3-3H 250uCi in ethanol, 1 mCi/ml, 20-30 Ci/mmol, M.W. 266.32, Shipped in Dry Ice, Exclusive