Glycosyl compounds
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451
Medchemexpress LLC D-Trehalose, carrier protein | 99-20-7 | 99.8% | 500 MG
D-Trehalose, carrier protein | 99-20-7 | 99.8% | 500 MG
452
Medchemexpress LLC Isrib (trans-isomer) | 1597403-47-8 | 99.49% | 451.34 | 50 MG
ISRIB (trans-isomer) is a potent inhibitor of PERK with an IC50 of 5 nM. It effectively reverses the effects of eIF2α phosphorylation and reduces the viability of cells subjected to PERK-activation by chronic endoplasmic reticulum stress. This trans-isomer is 100-fold more potent than cis-ISRIB, demonstrating stereospecific interaction with its cellular target.
- Potently reverses eIF2α phosphorylation (IC50=5 nM)
- Blocks eIF2α phosphorylation-induced stress granule (SG) formation
- Increases long-term memory in rodents
- Readily crosses the blood-brain barrier
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